JPS5753464A - Novel indazole derivative - Google Patents

Novel indazole derivative

Info

Publication number
JPS5753464A
JPS5753464A JP55128610A JP12861080A JPS5753464A JP S5753464 A JPS5753464 A JP S5753464A JP 55128610 A JP55128610 A JP 55128610A JP 12861080 A JP12861080 A JP 12861080A JP S5753464 A JPS5753464 A JP S5753464A
Authority
JP
Japan
Prior art keywords
formula
phthalimidoindazole
aminoindazole
remedy
reacted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP55128610A
Other languages
Japanese (ja)
Other versions
JPS6360743B2 (en
Inventor
Tadayuki Ibuki
Tasuke Sugihara
Takanori Sone
Hiroshi Kawakubo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Asahi Kasei Corp
Asahi Chemical Industry Co Ltd
Original Assignee
Asahi Chemical Industry Co Ltd
Asahi Kasei Kogyo KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asahi Chemical Industry Co Ltd, Asahi Kasei Kogyo KK filed Critical Asahi Chemical Industry Co Ltd
Priority to JP55128610A priority Critical patent/JPS5753464A/en
Priority to EP81107383A priority patent/EP0049779B1/en
Priority to DE8181107383T priority patent/DE3166987D1/en
Publication of JPS5753464A publication Critical patent/JPS5753464A/en
Priority to US06/569,524 priority patent/US4474964A/en
Priority to US06/636,420 priority patent/US4585869A/en
Priority to US06/636,293 priority patent/US4549023A/en
Publication of JPS6360743B2 publication Critical patent/JPS6360743B2/ja
Granted legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:An indazole derivative of formula I (n is an integer 1W6; R1 and R2 are H, 1W6C alkyl or heterocyclic ring having up to 5C atoms with the N atom in which the H atoms linked to one C atom on the heterocyclic ring may be substituted by an alkyl) and an acid addition salt thereof.
EXAMPLE: 1-(2-Dimethylaminoethyl)-3-aminoindazole.
USE: Useful as a nonsteroid remedy having a high anti-inflammatory activity and improved analgesic action, and a remedy for suppressing the side effects, e.g. ulceration in digestive tracts, of acidic nonsteroid anti-inflammatory agnets.
PROCESS: A 3-aminoindazole is reacted with phthalic anhydride to give 3-phthalimidoindazole, which is then reacted with an ω-halogenoalkylamine of formula II (X is halogen) to afford a 1-(aminoalkyl)-3-phthalimidoindazole. The protecting group of the amino group at the 3-position in the resultant compound is then removed with hydrazine hydrate to give the compound of formula I.
COPYRIGHT: (C)1982,JPO&Japio
JP55128610A 1980-09-18 1980-09-18 Novel indazole derivative Granted JPS5753464A (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP55128610A JPS5753464A (en) 1980-09-18 1980-09-18 Novel indazole derivative
EP81107383A EP0049779B1 (en) 1980-09-18 1981-09-17 3-aminoindazole derivatives and process for preparation thereof
DE8181107383T DE3166987D1 (en) 1980-09-18 1981-09-17 3-aminoindazole derivatives and process for preparation thereof
US06/569,524 US4474964A (en) 1980-09-18 1984-01-09 3-Aminoindazole derivatives
US06/636,420 US4585869A (en) 1980-09-18 1984-07-31 3-aminoindazole derivatives
US06/636,293 US4549023A (en) 1980-09-18 1984-07-31 3-Aminoindazole derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP55128610A JPS5753464A (en) 1980-09-18 1980-09-18 Novel indazole derivative

Publications (2)

Publication Number Publication Date
JPS5753464A true JPS5753464A (en) 1982-03-30
JPS6360743B2 JPS6360743B2 (en) 1988-11-25

Family

ID=14989036

Family Applications (1)

Application Number Title Priority Date Filing Date
JP55128610A Granted JPS5753464A (en) 1980-09-18 1980-09-18 Novel indazole derivative

Country Status (1)

Country Link
JP (1) JPS5753464A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6134269A (en) * 1984-07-19 1986-02-18 株式会社　京和機械製作所 Clamp apparatus for needle board in needle punching machine

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6134269A (en) * 1984-07-19 1986-02-18 株式会社　京和機械製作所 Clamp apparatus for needle board in needle punching machine
JPS6319625B2 (en) * 1984-07-19 1988-04-23 Kyowa Kikai Seisakusho Kk

Also Published As

Publication number Publication date
JPS6360743B2 (en) 1988-11-25

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