JPS54119493A - Purification of cephalosporins - Google Patents
Purification of cephalosporinsInfo
- Publication number
- JPS54119493A JPS54119493A JP2587678A JP2587678A JPS54119493A JP S54119493 A JPS54119493 A JP S54119493A JP 2587678 A JP2587678 A JP 2587678A JP 2587678 A JP2587678 A JP 2587678A JP S54119493 A JPS54119493 A JP S54119493A
- Authority
- JP
- Japan
- Prior art keywords
- derivative
- solvent
- amide
- pref
- solvate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Cephalosporin Compounds (AREA)
Abstract
PURPOSE: To obtain crystals of a specific cephalosporin derivative which is unstable and difficult to be purified, in a purity high enough to be administered as an antibiotic agent, by crystallizing the derivative as a solvant, from a solvent consisting of an amide-type solvent and an alcoholic solvent.
CONSTITUTION: High purity crystals of a solvate of a cephalosporin derivative of formula (A is pyridine ring; R is OH-substituted phenyl; Het is tetrazole substituted by 1-4C alkyl) are prepared by (1) dissolving the derivative in an amide-type solvent (pref. DMF, DMAC, etc.), (2) adding alcoholic solvent (pref. methanol, ethanol, etc.) dropwise to the solution, and (3) stirring or settling the mixture. The crystal thus obtained is a solvate of the cephalosporin derivative of formula with the amide-type solvent.
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2587678A JPS54119493A (en) | 1978-03-06 | 1978-03-06 | Purification of cephalosporins |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2587678A JPS54119493A (en) | 1978-03-06 | 1978-03-06 | Purification of cephalosporins |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS54119493A true JPS54119493A (en) | 1979-09-17 |
Family
ID=12177979
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2587678A Pending JPS54119493A (en) | 1978-03-06 | 1978-03-06 | Purification of cephalosporins |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS54119493A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997012889A1 (en) * | 1995-09-29 | 1997-04-10 | Gist-Brocades B.V. | Penicillin glycolate |
-
1978
- 1978-03-06 JP JP2587678A patent/JPS54119493A/en active Pending
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997012889A1 (en) * | 1995-09-29 | 1997-04-10 | Gist-Brocades B.V. | Penicillin glycolate |
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