JPS54119493A - Purification of cephalosporins - Google Patents

Purification of cephalosporins

Info

Publication number
JPS54119493A
JPS54119493A JP2587678A JP2587678A JPS54119493A JP S54119493 A JPS54119493 A JP S54119493A JP 2587678 A JP2587678 A JP 2587678A JP 2587678 A JP2587678 A JP 2587678A JP S54119493 A JPS54119493 A JP S54119493A
Authority
JP
Japan
Prior art keywords
derivative
solvent
amide
pref
solvate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2587678A
Other languages
Japanese (ja)
Inventor
Hirotada Yamada
Seiichi Masai
Hisao Tohiki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Chemical Co Ltd
Original Assignee
Sumitomo Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Chemical Co Ltd filed Critical Sumitomo Chemical Co Ltd
Priority to JP2587678A priority Critical patent/JPS54119493A/en
Publication of JPS54119493A publication Critical patent/JPS54119493A/en
Pending legal-status Critical Current

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  • Cephalosporin Compounds (AREA)

Abstract

PURPOSE: To obtain crystals of a specific cephalosporin derivative which is unstable and difficult to be purified, in a purity high enough to be administered as an antibiotic agent, by crystallizing the derivative as a solvant, from a solvent consisting of an amide-type solvent and an alcoholic solvent.
CONSTITUTION: High purity crystals of a solvate of a cephalosporin derivative of formula (A is pyridine ring; R is OH-substituted phenyl; Het is tetrazole substituted by 1-4C alkyl) are prepared by (1) dissolving the derivative in an amide-type solvent (pref. DMF, DMAC, etc.), (2) adding alcoholic solvent (pref. methanol, ethanol, etc.) dropwise to the solution, and (3) stirring or settling the mixture. The crystal thus obtained is a solvate of the cephalosporin derivative of formula with the amide-type solvent.
COPYRIGHT: (C)1979,JPO&Japio
JP2587678A 1978-03-06 1978-03-06 Purification of cephalosporins Pending JPS54119493A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2587678A JPS54119493A (en) 1978-03-06 1978-03-06 Purification of cephalosporins

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2587678A JPS54119493A (en) 1978-03-06 1978-03-06 Purification of cephalosporins

Publications (1)

Publication Number Publication Date
JPS54119493A true JPS54119493A (en) 1979-09-17

Family

ID=12177979

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2587678A Pending JPS54119493A (en) 1978-03-06 1978-03-06 Purification of cephalosporins

Country Status (1)

Country Link
JP (1) JPS54119493A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997012889A1 (en) * 1995-09-29 1997-04-10 Gist-Brocades B.V. Penicillin glycolate

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997012889A1 (en) * 1995-09-29 1997-04-10 Gist-Brocades B.V. Penicillin glycolate

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