JPS54119497A - N-acylamino-alpha-arylacetamidocephalosporin derivative - Google Patents
N-acylamino-alpha-arylacetamidocephalosporin derivativeInfo
- Publication number
- JPS54119497A JPS54119497A JP2691278A JP2691278A JPS54119497A JP S54119497 A JPS54119497 A JP S54119497A JP 2691278 A JP2691278 A JP 2691278A JP 2691278 A JP2691278 A JP 2691278A JP S54119497 A JPS54119497 A JP S54119497A
- Authority
- JP
- Japan
- Prior art keywords
- acid
- reaction
- derivative
- organic solvent
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Cephalosporin Compounds (AREA)
Abstract
PURPOSE: To obtain highly pure crystals of the title compound which is unstable at high temp. or with acid or alkali, and is prepared by the conversion reaction of a specific compound, by adding an acid to the reaction mixture in the presence of an organic solvent, and filtering the produced impurities.
CONSTITUTION: A compound I (A is pyridine ring; R is OH-substituted phenol) is cenverted into a cephalosporin derivative II (Het is tetrazole ring substituted by 1W4C lower alkyl). After the completion of the reaction, the reaction mixture is added with an acid such as sulfuric acid, hydrochloric acid, etc., in the presence of an organic solvent selected from amides, ketones, alcohols, nitriles, and cyclic ethers, to attain a pH of about 2, stirred at 0W35°C, and filtered to remove the impurities produced by the conversion reaction. The filtrate is diluted with water to afford the cephalosporin derivative II as crystal.
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2691278A JPS54119497A (en) | 1978-03-08 | 1978-03-08 | N-acylamino-alpha-arylacetamidocephalosporin derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2691278A JPS54119497A (en) | 1978-03-08 | 1978-03-08 | N-acylamino-alpha-arylacetamidocephalosporin derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS54119497A true JPS54119497A (en) | 1979-09-17 |
Family
ID=12206419
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2691278A Pending JPS54119497A (en) | 1978-03-08 | 1978-03-08 | N-acylamino-alpha-arylacetamidocephalosporin derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS54119497A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0035413A2 (en) * | 1980-03-05 | 1981-09-09 | Sumitomo Chemical Company, Limited | Antimicrobial 7-(alpha-acylamino-alpha-arylacetamido)-3-(substituted methyl)cephalosporin compounds, their compositions and production |
-
1978
- 1978-03-08 JP JP2691278A patent/JPS54119497A/en active Pending
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0035413A2 (en) * | 1980-03-05 | 1981-09-09 | Sumitomo Chemical Company, Limited | Antimicrobial 7-(alpha-acylamino-alpha-arylacetamido)-3-(substituted methyl)cephalosporin compounds, their compositions and production |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
SK134399A3 (en) | Cefdinir in the form of a salt with dicyclohexylamine, a process for its production and its use | |
JPS54119497A (en) | N-acylamino-alpha-arylacetamidocephalosporin derivative | |
JPS55104248A (en) | Improved preparation of azo compound | |
JPS57203049A (en) | Preparation of amide derivative | |
JPS54106488A (en) | Purification for d-penicillamine | |
US4546203A (en) | Facile synthesis of β-hydroxy-β-methylglutaric acid | |
JPS55122788A (en) | Preparation of cephalosporin compound | |
JPS5569531A (en) | Purification of hydroquinone | |
GB1022818A (en) | Melamine refining procedure | |
JPS55144422A (en) | Purification of cis-dichlorodiammineplatinum(2) | |
US4244870A (en) | Dimethyl sulfoxide adducts of penicillins | |
JPS5711977A (en) | Purifying method of 5-acetamido-1,2,3-thiadiazole | |
JPS5585538A (en) | Separation of cis- and trans-1-methyl-4-isohexyl- cyclohexanecarboxylic acid | |
JPS54145628A (en) | Preparation of p-hydroxyphenylglycine | |
JPS565483A (en) | Purification of cephalosporin compound | |
JPS5515434A (en) | Separation of substituted salicylic acid metal salt from aqueous slurry | |
JPS54141794A (en) | Preparation of n-acylcephamycin c and its salt with organic base | |
JPS5538305A (en) | Preparation of hedta | |
JPS54157592A (en) | Preparation of high-purity acylaminoacyl- amidopenicillanic acid | |
EP0366808A4 (en) | Method of crystallization and purification for obtaining stabe _g(b) crystal of tetrakis 3-(3,5-di-tertiary-butyl-4-hydroxyphenyl)propionyloxymethyl¨methane on an industrial scale | |
JPS5513245A (en) | Preparation of m-aminoacetanilide | |
CA1066291A (en) | 3-formyl-4-methyl-2,6-dihydroxypyridine and a process for its preparation | |
JPS5695158A (en) | Preparation of n-carbamoyl-p-hydroxyphenylglycine | |
JPS5484559A (en) | Preparation of beta-hydroxynaphthamide | |
JPS54112881A (en) | Preparation of 2-mercaptopyrimidine hydrochloride |