JPS54119497A - N-acylamino-alpha-arylacetamidocephalosporin derivative - Google Patents

N-acylamino-alpha-arylacetamidocephalosporin derivative

Info

Publication number
JPS54119497A
JPS54119497A JP2691278A JP2691278A JPS54119497A JP S54119497 A JPS54119497 A JP S54119497A JP 2691278 A JP2691278 A JP 2691278A JP 2691278 A JP2691278 A JP 2691278A JP S54119497 A JPS54119497 A JP S54119497A
Authority
JP
Japan
Prior art keywords
acid
reaction
derivative
organic solvent
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2691278A
Other languages
Japanese (ja)
Inventor
Hirotada Yamada
Seiichi Jinbo
Hiroyuki Suzuki
Hisao Tohiki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Chemical Co Ltd
Original Assignee
Sumitomo Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Chemical Co Ltd filed Critical Sumitomo Chemical Co Ltd
Priority to JP2691278A priority Critical patent/JPS54119497A/en
Publication of JPS54119497A publication Critical patent/JPS54119497A/en
Pending legal-status Critical Current

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  • Cephalosporin Compounds (AREA)

Abstract

PURPOSE: To obtain highly pure crystals of the title compound which is unstable at high temp. or with acid or alkali, and is prepared by the conversion reaction of a specific compound, by adding an acid to the reaction mixture in the presence of an organic solvent, and filtering the produced impurities.
CONSTITUTION: A compound I (A is pyridine ring; R is OH-substituted phenol) is cenverted into a cephalosporin derivative II (Het is tetrazole ring substituted by 1W4C lower alkyl). After the completion of the reaction, the reaction mixture is added with an acid such as sulfuric acid, hydrochloric acid, etc., in the presence of an organic solvent selected from amides, ketones, alcohols, nitriles, and cyclic ethers, to attain a pH of about 2, stirred at 0W35°C, and filtered to remove the impurities produced by the conversion reaction. The filtrate is diluted with water to afford the cephalosporin derivative II as crystal.
COPYRIGHT: (C)1979,JPO&Japio
JP2691278A 1978-03-08 1978-03-08 N-acylamino-alpha-arylacetamidocephalosporin derivative Pending JPS54119497A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2691278A JPS54119497A (en) 1978-03-08 1978-03-08 N-acylamino-alpha-arylacetamidocephalosporin derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2691278A JPS54119497A (en) 1978-03-08 1978-03-08 N-acylamino-alpha-arylacetamidocephalosporin derivative

Publications (1)

Publication Number Publication Date
JPS54119497A true JPS54119497A (en) 1979-09-17

Family

ID=12206419

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2691278A Pending JPS54119497A (en) 1978-03-08 1978-03-08 N-acylamino-alpha-arylacetamidocephalosporin derivative

Country Status (1)

Country Link
JP (1) JPS54119497A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0035413A2 (en) * 1980-03-05 1981-09-09 Sumitomo Chemical Company, Limited Antimicrobial 7-(alpha-acylamino-alpha-arylacetamido)-3-(substituted methyl)cephalosporin compounds, their compositions and production

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0035413A2 (en) * 1980-03-05 1981-09-09 Sumitomo Chemical Company, Limited Antimicrobial 7-(alpha-acylamino-alpha-arylacetamido)-3-(substituted methyl)cephalosporin compounds, their compositions and production

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