JPS54157592A - Preparation of high-purity acylaminoacyl- amidopenicillanic acid - Google Patents
Preparation of high-purity acylaminoacyl- amidopenicillanic acidInfo
- Publication number
- JPS54157592A JPS54157592A JP6614478A JP6614478A JPS54157592A JP S54157592 A JPS54157592 A JP S54157592A JP 6614478 A JP6614478 A JP 6614478A JP 6614478 A JP6614478 A JP 6614478A JP S54157592 A JPS54157592 A JP S54157592A
- Authority
- JP
- Japan
- Prior art keywords
- dmso
- adduct
- acid
- purity
- crystals
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
PURPOSE: To obtain the title compound in high purity readily, by converting an antibacterial crude sodium salt of 6-acylaminoacylamidopenicillanic acid into a novel DMSO adduct which is crystalline and has improved storage stability, and by removing the DMSO.
CONSTITUTION: Crude sodium salt of 6-[D--α-(4-hydroxy-1, 5-naphthyridine- 3-carboxamido)-(ρ-hydroxy or unsubstituted)-phenylacetamido]-penicillanic acid is reacted with DMSO to form its DMSO adduct as crystals. DMSO is then removed from the adduct by adding a solvent, e.g. acetone, which will not dissolve the objective substance, to an aqueous solution of the adduct, whose pH is adjusted, to take out the substance as crystals.
EFFECT: Wide antibacterial spectrum and particularly effective for bacillus pyocyaneus.
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (12)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP6614478A JPS54157592A (en) | 1978-05-31 | 1978-05-31 | Preparation of high-purity acylaminoacyl- amidopenicillanic acid |
NO791743A NO155346C (en) | 1978-05-31 | 1979-05-28 | FRGM. FOR PURIFICATION OF RAW SODIUM 6- (D (-) - ALFA- (4-HYDROXY-1,5-NAFTYRIDINE-3-CARBOXAMIDO) -PHENYLACETAMIDO) -PENICILLANATE OR SODIUM-6- (D (-) - ALFA- ( 4-hydroxy-1,5-naphthyridine-3-carboxamido) -p-HYDROSYFENYLACETAMIDO) penicillanate |
AU47515/79A AU523989B2 (en) | 1978-05-31 | 1979-05-29 | Dimethyl sulfoxide adducts of penicillins |
US06/042,952 US4244870A (en) | 1978-05-31 | 1979-05-29 | Dimethyl sulfoxide adducts of penicillins |
ES481103A ES8207182A1 (en) | 1978-05-31 | 1979-05-30 | Dimethyl sulfoxide adducts of sodium 6-(D(-)-alpha-(4-hydroxy-1,5-naphthyridine-3-carboxamido)phenylacetamido)penicillanate or the derivative thereof bearing a hydroxyl group at the p-position of the phenyl group, methods for their preparation and decomposition, and their use as intermediates for purifying the crude penicillins. |
EP79300992A EP0006688B1 (en) | 1978-05-31 | 1979-05-30 | Dimethyl sulfoxide adducts of sodium 6-(d(-)-alpha-(4-hydroxy-1,5-naphthyridine-3-carboxamido)phenylacetamido)penicillanate or the derivative thereof bearing a hydroxyl group at the p-position of the phenyl group, methods for their preparation and decomposition, and their use as intermediates for purifying the crude penicillins |
HUSU001044 HU180091B (en) | 1978-05-31 | 1979-05-30 | Process for producing sodium salt of 6-square bracket-d-bracket-minus-aracket closed-alpha-aracket-4-hydroxy-1,5-naphtiridine-3-carboxamido-bracket closed-phenylacetamido- or -p-hydroxy-phenylacetamido-square bracket closed-pename-3-carboxylic acids |
DE7979300992T DE2962882D1 (en) | 1978-05-31 | 1979-05-30 | Dimethyl sulfoxide adducts of sodium 6-(d(-)-alpha-(4-hydroxy-1,5-naphthyridine-3-carboxamido)phenylacetamido)penicillanate or the derivative thereof bearing a hydroxyl group at the p-position of the phenyl group, methods for their preparation and decomposition, and their use as intermediates for purifying the crude penicillins |
DK226479A DK150491C (en) | 1978-05-31 | 1979-05-30 | PROCEDURE FOR CLEANING RAATE SODIUM 6- (D (-) - ALFA- (4-HYDROXY-1,5-NAPHTHYRIDINE-3-CAR-BOXAMIDO) PHENYLACETAMIDO) -PENICILLANATE OR THE PENYLIFICATION OF THE PHENYL GROUP DIVYLED |
CA328,851A CA1129844A (en) | 1978-05-31 | 1979-05-31 | Dimethyl sulfoxide adducts of penicillins |
FI791742A FI72121C (en) | 1978-05-31 | 1979-05-31 | SOM MELLANPROTUKT ANVAEND DIMETHYLSULFOXIDADDUKT AV SODIUM-6- / D (-) - - (4-HYDROXI-1,5-NAPHTHYRIDINE-3-CARBOXAMIDO) -PHENYLACETAMIDO / PENICILLANATE ELLER DESSER-PENYLGRP |
NO793952A NO793952L (en) | 1978-05-31 | 1979-12-04 | PROCEDURE FOR DECOMPOSITION OF DIMETHYL-SULFOXIDE ADDUCTS OF SODIUM-PENICILLINATE DERIVATIVES |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP6614478A JPS54157592A (en) | 1978-05-31 | 1978-05-31 | Preparation of high-purity acylaminoacyl- amidopenicillanic acid |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS54157592A true JPS54157592A (en) | 1979-12-12 |
Family
ID=13307364
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP6614478A Pending JPS54157592A (en) | 1978-05-31 | 1978-05-31 | Preparation of high-purity acylaminoacyl- amidopenicillanic acid |
Country Status (3)
Country | Link |
---|---|
JP (1) | JPS54157592A (en) |
HU (1) | HU180091B (en) |
NO (1) | NO793952L (en) |
-
1978
- 1978-05-31 JP JP6614478A patent/JPS54157592A/en active Pending
-
1979
- 1979-05-30 HU HUSU001044 patent/HU180091B/en unknown
- 1979-12-04 NO NO793952A patent/NO793952L/en unknown
Also Published As
Publication number | Publication date |
---|---|
NO793952L (en) | 1979-12-03 |
HU180091B (en) | 1983-01-28 |
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