JPS54157592A - Preparation of high-purity acylaminoacyl- amidopenicillanic acid - Google Patents

Preparation of high-purity acylaminoacyl- amidopenicillanic acid

Info

Publication number
JPS54157592A
JPS54157592A JP6614478A JP6614478A JPS54157592A JP S54157592 A JPS54157592 A JP S54157592A JP 6614478 A JP6614478 A JP 6614478A JP 6614478 A JP6614478 A JP 6614478A JP S54157592 A JPS54157592 A JP S54157592A
Authority
JP
Japan
Prior art keywords
dmso
adduct
acid
purity
crystals
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP6614478A
Other languages
Japanese (ja)
Inventor
Norihiko Tanno
Takashi Harimoto
Shinji Ueda
Hisao Tohiki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Chemical Co Ltd
Original Assignee
Sumitomo Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Chemical Co Ltd filed Critical Sumitomo Chemical Co Ltd
Priority to JP6614478A priority Critical patent/JPS54157592A/en
Priority to NO791743A priority patent/NO155346C/en
Priority to AU47515/79A priority patent/AU523989B2/en
Priority to US06/042,952 priority patent/US4244870A/en
Priority to ES481103A priority patent/ES8207182A1/en
Priority to EP79300992A priority patent/EP0006688B1/en
Priority to HUSU001044 priority patent/HU180091B/en
Priority to DE7979300992T priority patent/DE2962882D1/en
Priority to DK226479A priority patent/DK150491C/en
Priority to CA328,851A priority patent/CA1129844A/en
Priority to FI791742A priority patent/FI72121C/en
Priority to NO793952A priority patent/NO793952L/en
Publication of JPS54157592A publication Critical patent/JPS54157592A/en
Pending legal-status Critical Current

Links

Abstract

PURPOSE: To obtain the title compound in high purity readily, by converting an antibacterial crude sodium salt of 6-acylaminoacylamidopenicillanic acid into a novel DMSO adduct which is crystalline and has improved storage stability, and by removing the DMSO.
CONSTITUTION: Crude sodium salt of 6-[D--α-(4-hydroxy-1, 5-naphthyridine- 3-carboxamido)-(ρ-hydroxy or unsubstituted)-phenylacetamido]-penicillanic acid is reacted with DMSO to form its DMSO adduct as crystals. DMSO is then removed from the adduct by adding a solvent, e.g. acetone, which will not dissolve the objective substance, to an aqueous solution of the adduct, whose pH is adjusted, to take out the substance as crystals.
EFFECT: Wide antibacterial spectrum and particularly effective for bacillus pyocyaneus.
COPYRIGHT: (C)1979,JPO&Japio
JP6614478A 1978-05-31 1978-05-31 Preparation of high-purity acylaminoacyl- amidopenicillanic acid Pending JPS54157592A (en)

Priority Applications (12)

Application Number Priority Date Filing Date Title
JP6614478A JPS54157592A (en) 1978-05-31 1978-05-31 Preparation of high-purity acylaminoacyl- amidopenicillanic acid
NO791743A NO155346C (en) 1978-05-31 1979-05-28 FRGM. FOR PURIFICATION OF RAW SODIUM 6- (D (-) - ALFA- (4-HYDROXY-1,5-NAFTYRIDINE-3-CARBOXAMIDO) -PHENYLACETAMIDO) -PENICILLANATE OR SODIUM-6- (D (-) - ALFA- ( 4-hydroxy-1,5-naphthyridine-3-carboxamido) -p-HYDROSYFENYLACETAMIDO) penicillanate
AU47515/79A AU523989B2 (en) 1978-05-31 1979-05-29 Dimethyl sulfoxide adducts of penicillins
US06/042,952 US4244870A (en) 1978-05-31 1979-05-29 Dimethyl sulfoxide adducts of penicillins
ES481103A ES8207182A1 (en) 1978-05-31 1979-05-30 Dimethyl sulfoxide adducts of sodium 6-(D(-)-alpha-(4-hydroxy-1,5-naphthyridine-3-carboxamido)phenylacetamido)penicillanate or the derivative thereof bearing a hydroxyl group at the p-position of the phenyl group, methods for their preparation and decomposition, and their use as intermediates for purifying the crude penicillins.
EP79300992A EP0006688B1 (en) 1978-05-31 1979-05-30 Dimethyl sulfoxide adducts of sodium 6-(d(-)-alpha-(4-hydroxy-1,5-naphthyridine-3-carboxamido)phenylacetamido)penicillanate or the derivative thereof bearing a hydroxyl group at the p-position of the phenyl group, methods for their preparation and decomposition, and their use as intermediates for purifying the crude penicillins
HUSU001044 HU180091B (en) 1978-05-31 1979-05-30 Process for producing sodium salt of 6-square bracket-d-bracket-minus-aracket closed-alpha-aracket-4-hydroxy-1,5-naphtiridine-3-carboxamido-bracket closed-phenylacetamido- or -p-hydroxy-phenylacetamido-square bracket closed-pename-3-carboxylic acids
DE7979300992T DE2962882D1 (en) 1978-05-31 1979-05-30 Dimethyl sulfoxide adducts of sodium 6-(d(-)-alpha-(4-hydroxy-1,5-naphthyridine-3-carboxamido)phenylacetamido)penicillanate or the derivative thereof bearing a hydroxyl group at the p-position of the phenyl group, methods for their preparation and decomposition, and their use as intermediates for purifying the crude penicillins
DK226479A DK150491C (en) 1978-05-31 1979-05-30 PROCEDURE FOR CLEANING RAATE SODIUM 6- (D (-) - ALFA- (4-HYDROXY-1,5-NAPHTHYRIDINE-3-CAR-BOXAMIDO) PHENYLACETAMIDO) -PENICILLANATE OR THE PENYLIFICATION OF THE PHENYL GROUP DIVYLED
CA328,851A CA1129844A (en) 1978-05-31 1979-05-31 Dimethyl sulfoxide adducts of penicillins
FI791742A FI72121C (en) 1978-05-31 1979-05-31 SOM MELLANPROTUKT ANVAEND DIMETHYLSULFOXIDADDUKT AV SODIUM-6- / D (-) - - (4-HYDROXI-1,5-NAPHTHYRIDINE-3-CARBOXAMIDO) -PHENYLACETAMIDO / PENICILLANATE ELLER DESSER-PENYLGRP
NO793952A NO793952L (en) 1978-05-31 1979-12-04 PROCEDURE FOR DECOMPOSITION OF DIMETHYL-SULFOXIDE ADDUCTS OF SODIUM-PENICILLINATE DERIVATIVES

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP6614478A JPS54157592A (en) 1978-05-31 1978-05-31 Preparation of high-purity acylaminoacyl- amidopenicillanic acid

Publications (1)

Publication Number Publication Date
JPS54157592A true JPS54157592A (en) 1979-12-12

Family

ID=13307364

Family Applications (1)

Application Number Title Priority Date Filing Date
JP6614478A Pending JPS54157592A (en) 1978-05-31 1978-05-31 Preparation of high-purity acylaminoacyl- amidopenicillanic acid

Country Status (3)

Country Link
JP (1) JPS54157592A (en)
HU (1) HU180091B (en)
NO (1) NO793952L (en)

Also Published As

Publication number Publication date
NO793952L (en) 1979-12-03
HU180091B (en) 1983-01-28

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