JPS54157593A - Preparation of high-purity 6-acylaminoacylamido penicillanic acid - Google Patents

Preparation of high-purity 6-acylaminoacylamido penicillanic acid

Info

Publication number
JPS54157593A
JPS54157593A JP6614578A JP6614578A JPS54157593A JP S54157593 A JPS54157593 A JP S54157593A JP 6614578 A JP6614578 A JP 6614578A JP 6614578 A JP6614578 A JP 6614578A JP S54157593 A JPS54157593 A JP S54157593A
Authority
JP
Japan
Prior art keywords
sodium salt
acid
dmso
penicillanic acid
acylaminoacylamido
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP6614578A
Other languages
Japanese (ja)
Inventor
Norihiko Tanno
Takashi Harimoto
Shinji Ueda
Hisao Tohiki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Chemical Co Ltd
Original Assignee
Sumitomo Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Chemical Co Ltd filed Critical Sumitomo Chemical Co Ltd
Priority to JP6614578A priority Critical patent/JPS54157593A/en
Priority to NO791743A priority patent/NO155346C/en
Priority to AU47515/79A priority patent/AU523989B2/en
Priority to US06/042,952 priority patent/US4244870A/en
Priority to ES481103A priority patent/ES8207182A1/en
Priority to HUSU001016 priority patent/HU176714B/en
Priority to EP79300992A priority patent/EP0006688B1/en
Priority to DK226479A priority patent/DK150491C/en
Priority to DE7979300992T priority patent/DE2962882D1/en
Priority to FI791742A priority patent/FI72121C/en
Priority to CA328,851A priority patent/CA1129844A/en
Publication of JPS54157593A publication Critical patent/JPS54157593A/en
Pending legal-status Critical Current

Links

Abstract

NEW MATERIAL:A DMSO adduct of sodium salt of 6-[D--α-(4-hydroxy-1, 5- naphthyridine-3-carboxamido)-(p-hydroxy or unsubstituted)-phenylacetamido)penicillanic acid.
USE: Antibacterials and intermediates for their synthesis. Crystalline, easily handleable, and improved storage stability. Valuable as an intermediate for the purification of sodium salt of 6-acyl-aminoacylamidopenicillanic acid particularly effective for bacillus pyocyaneus.
PROCESS: Sodium salt of 6-acylaminoacylamidopenicillanic acid is reacted with DMSO in a solvent, e.g. hydrous methanol, at room temperature to 60°C to give the objective DMSO adduct.
COPYRIGHT: (C)1979,JPO&Japio
JP6614578A 1978-05-31 1978-05-31 Preparation of high-purity 6-acylaminoacylamido penicillanic acid Pending JPS54157593A (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
JP6614578A JPS54157593A (en) 1978-05-31 1978-05-31 Preparation of high-purity 6-acylaminoacylamido penicillanic acid
NO791743A NO155346C (en) 1978-05-31 1979-05-28 FRGM. FOR PURIFICATION OF RAW SODIUM 6- (D (-) - ALFA- (4-HYDROXY-1,5-NAFTYRIDINE-3-CARBOXAMIDO) -PHENYLACETAMIDO) -PENICILLANATE OR SODIUM-6- (D (-) - ALFA- ( 4-hydroxy-1,5-naphthyridine-3-carboxamido) -p-HYDROSYFENYLACETAMIDO) penicillanate
AU47515/79A AU523989B2 (en) 1978-05-31 1979-05-29 Dimethyl sulfoxide adducts of penicillins
US06/042,952 US4244870A (en) 1978-05-31 1979-05-29 Dimethyl sulfoxide adducts of penicillins
ES481103A ES8207182A1 (en) 1978-05-31 1979-05-30 Dimethyl sulfoxide adducts of sodium 6-(D(-)-alpha-(4-hydroxy-1,5-naphthyridine-3-carboxamido)phenylacetamido)penicillanate or the derivative thereof bearing a hydroxyl group at the p-position of the phenyl group, methods for their preparation and decomposition, and their use as intermediates for purifying the crude penicillins.
HUSU001016 HU176714B (en) 1978-05-31 1979-05-30 Process for producing dimetyl-sulfoxide adductes of pename-3-carboxylic acid derivatives
EP79300992A EP0006688B1 (en) 1978-05-31 1979-05-30 Dimethyl sulfoxide adducts of sodium 6-(d(-)-alpha-(4-hydroxy-1,5-naphthyridine-3-carboxamido)phenylacetamido)penicillanate or the derivative thereof bearing a hydroxyl group at the p-position of the phenyl group, methods for their preparation and decomposition, and their use as intermediates for purifying the crude penicillins
DK226479A DK150491C (en) 1978-05-31 1979-05-30 PROCEDURE FOR CLEANING RAATE SODIUM 6- (D (-) - ALFA- (4-HYDROXY-1,5-NAPHTHYRIDINE-3-CAR-BOXAMIDO) PHENYLACETAMIDO) -PENICILLANATE OR THE PENYLIFICATION OF THE PHENYL GROUP DIVYLED
DE7979300992T DE2962882D1 (en) 1978-05-31 1979-05-30 Dimethyl sulfoxide adducts of sodium 6-(d(-)-alpha-(4-hydroxy-1,5-naphthyridine-3-carboxamido)phenylacetamido)penicillanate or the derivative thereof bearing a hydroxyl group at the p-position of the phenyl group, methods for their preparation and decomposition, and their use as intermediates for purifying the crude penicillins
FI791742A FI72121C (en) 1978-05-31 1979-05-31 SOM MELLANPROTUKT ANVAEND DIMETHYLSULFOXIDADDUKT AV SODIUM-6- / D (-) - - (4-HYDROXI-1,5-NAPHTHYRIDINE-3-CARBOXAMIDO) -PHENYLACETAMIDO / PENICILLANATE ELLER DESSER-PENYLGRP
CA328,851A CA1129844A (en) 1978-05-31 1979-05-31 Dimethyl sulfoxide adducts of penicillins

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP6614578A JPS54157593A (en) 1978-05-31 1978-05-31 Preparation of high-purity 6-acylaminoacylamido penicillanic acid

Publications (1)

Publication Number Publication Date
JPS54157593A true JPS54157593A (en) 1979-12-12

Family

ID=13307393

Family Applications (1)

Application Number Title Priority Date Filing Date
JP6614578A Pending JPS54157593A (en) 1978-05-31 1978-05-31 Preparation of high-purity 6-acylaminoacylamido penicillanic acid

Country Status (2)

Country Link
JP (1) JPS54157593A (en)
HU (1) HU176714B (en)

Also Published As

Publication number Publication date
HU176714B (en) 1981-04-28

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