JPS54157593A - Preparation of high-purity 6-acylaminoacylamido penicillanic acid - Google Patents
Preparation of high-purity 6-acylaminoacylamido penicillanic acidInfo
- Publication number
- JPS54157593A JPS54157593A JP6614578A JP6614578A JPS54157593A JP S54157593 A JPS54157593 A JP S54157593A JP 6614578 A JP6614578 A JP 6614578A JP 6614578 A JP6614578 A JP 6614578A JP S54157593 A JPS54157593 A JP S54157593A
- Authority
- JP
- Japan
- Prior art keywords
- sodium salt
- acid
- dmso
- penicillanic acid
- acylaminoacylamido
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
NEW MATERIAL:A DMSO adduct of sodium salt of 6-[D--α-(4-hydroxy-1, 5- naphthyridine-3-carboxamido)-(p-hydroxy or unsubstituted)-phenylacetamido)penicillanic acid.
USE: Antibacterials and intermediates for their synthesis. Crystalline, easily handleable, and improved storage stability. Valuable as an intermediate for the purification of sodium salt of 6-acyl-aminoacylamidopenicillanic acid particularly effective for bacillus pyocyaneus.
PROCESS: Sodium salt of 6-acylaminoacylamidopenicillanic acid is reacted with DMSO in a solvent, e.g. hydrous methanol, at room temperature to 60°C to give the objective DMSO adduct.
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP6614578A JPS54157593A (en) | 1978-05-31 | 1978-05-31 | Preparation of high-purity 6-acylaminoacylamido penicillanic acid |
NO791743A NO155346C (en) | 1978-05-31 | 1979-05-28 | FRGM. FOR PURIFICATION OF RAW SODIUM 6- (D (-) - ALFA- (4-HYDROXY-1,5-NAFTYRIDINE-3-CARBOXAMIDO) -PHENYLACETAMIDO) -PENICILLANATE OR SODIUM-6- (D (-) - ALFA- ( 4-hydroxy-1,5-naphthyridine-3-carboxamido) -p-HYDROSYFENYLACETAMIDO) penicillanate |
AU47515/79A AU523989B2 (en) | 1978-05-31 | 1979-05-29 | Dimethyl sulfoxide adducts of penicillins |
US06/042,952 US4244870A (en) | 1978-05-31 | 1979-05-29 | Dimethyl sulfoxide adducts of penicillins |
ES481103A ES8207182A1 (en) | 1978-05-31 | 1979-05-30 | Dimethyl sulfoxide adducts of sodium 6-(D(-)-alpha-(4-hydroxy-1,5-naphthyridine-3-carboxamido)phenylacetamido)penicillanate or the derivative thereof bearing a hydroxyl group at the p-position of the phenyl group, methods for their preparation and decomposition, and their use as intermediates for purifying the crude penicillins. |
HUSU001016 HU176714B (en) | 1978-05-31 | 1979-05-30 | Process for producing dimetyl-sulfoxide adductes of pename-3-carboxylic acid derivatives |
EP79300992A EP0006688B1 (en) | 1978-05-31 | 1979-05-30 | Dimethyl sulfoxide adducts of sodium 6-(d(-)-alpha-(4-hydroxy-1,5-naphthyridine-3-carboxamido)phenylacetamido)penicillanate or the derivative thereof bearing a hydroxyl group at the p-position of the phenyl group, methods for their preparation and decomposition, and their use as intermediates for purifying the crude penicillins |
DK226479A DK150491C (en) | 1978-05-31 | 1979-05-30 | PROCEDURE FOR CLEANING RAATE SODIUM 6- (D (-) - ALFA- (4-HYDROXY-1,5-NAPHTHYRIDINE-3-CAR-BOXAMIDO) PHENYLACETAMIDO) -PENICILLANATE OR THE PENYLIFICATION OF THE PHENYL GROUP DIVYLED |
DE7979300992T DE2962882D1 (en) | 1978-05-31 | 1979-05-30 | Dimethyl sulfoxide adducts of sodium 6-(d(-)-alpha-(4-hydroxy-1,5-naphthyridine-3-carboxamido)phenylacetamido)penicillanate or the derivative thereof bearing a hydroxyl group at the p-position of the phenyl group, methods for their preparation and decomposition, and their use as intermediates for purifying the crude penicillins |
FI791742A FI72121C (en) | 1978-05-31 | 1979-05-31 | SOM MELLANPROTUKT ANVAEND DIMETHYLSULFOXIDADDUKT AV SODIUM-6- / D (-) - - (4-HYDROXI-1,5-NAPHTHYRIDINE-3-CARBOXAMIDO) -PHENYLACETAMIDO / PENICILLANATE ELLER DESSER-PENYLGRP |
CA328,851A CA1129844A (en) | 1978-05-31 | 1979-05-31 | Dimethyl sulfoxide adducts of penicillins |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP6614578A JPS54157593A (en) | 1978-05-31 | 1978-05-31 | Preparation of high-purity 6-acylaminoacylamido penicillanic acid |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS54157593A true JPS54157593A (en) | 1979-12-12 |
Family
ID=13307393
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP6614578A Pending JPS54157593A (en) | 1978-05-31 | 1978-05-31 | Preparation of high-purity 6-acylaminoacylamido penicillanic acid |
Country Status (2)
Country | Link |
---|---|
JP (1) | JPS54157593A (en) |
HU (1) | HU176714B (en) |
-
1978
- 1978-05-31 JP JP6614578A patent/JPS54157593A/en active Pending
-
1979
- 1979-05-30 HU HUSU001016 patent/HU176714B/en unknown
Also Published As
Publication number | Publication date |
---|---|
HU176714B (en) | 1981-04-28 |
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