JPS5536434A - 4-phenyl-4-oxo-2-butenoic acid derivative and its preparation - Google Patents
4-phenyl-4-oxo-2-butenoic acid derivative and its preparationInfo
- Publication number
- JPS5536434A JPS5536434A JP11006578A JP11006578A JPS5536434A JP S5536434 A JPS5536434 A JP S5536434A JP 11006578 A JP11006578 A JP 11006578A JP 11006578 A JP11006578 A JP 11006578A JP S5536434 A JPS5536434 A JP S5536434A
- Authority
- JP
- Japan
- Prior art keywords
- halogen
- oxo
- phenyl
- lower alkyl
- butenoic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
NEW MATERIAL:A 4-phenyl-4-oxo-2-butenoic acid derivative of formula I (R1 is H, OH or halogen; R2 and R4 are halogen, or one of them is halogen and other is H; R3 is H, lower alkyl, cycloalkyl, OH, halogen or a group II; R5 and R6 are H or lower alkyl; R7 is 1W3C lower alkyl).
EXAMPLE: 4-(3-Bromophenyl)-4-oxo-2-butenoic acid.
USE: An intermediate of a 6-phenyl-3(2H)pyridazinone derivative having wide antibacterial spectrum. An intermediate of a hypotensor.
PROCESS: A compound of formula III (R1' is H, etc; R2' and R4' are H, or one of them is halogen and the other is H; R3' is H, lower alkyl, etc.) is reacted with a sufficiently large amount of anhydrous aluminum chloride to form a complex compound; and the complex compound thus obtained is treated with a halogenating agent and decomposed with an acid to obtain the objective compound I.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP11006578A JPS5536434A (en) | 1978-09-07 | 1978-09-07 | 4-phenyl-4-oxo-2-butenoic acid derivative and its preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP11006578A JPS5536434A (en) | 1978-09-07 | 1978-09-07 | 4-phenyl-4-oxo-2-butenoic acid derivative and its preparation |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5536434A true JPS5536434A (en) | 1980-03-14 |
JPS6116265B2 JPS6116265B2 (en) | 1986-04-28 |
Family
ID=14526166
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP11006578A Granted JPS5536434A (en) | 1978-09-07 | 1978-09-07 | 4-phenyl-4-oxo-2-butenoic acid derivative and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5536434A (en) |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4454155A (en) * | 1981-10-22 | 1984-06-12 | Roussel Uclaf | Pharmaceutical compositions containing a mono-substituted derivative of 4-phenyl-4-oxobuten-2-oic acid, and methods of using them in treating gastric and gastroduodenal ailments |
US4473583A (en) * | 1981-10-22 | 1984-09-25 | Roussel Uclaf | Compositions containing certain derivatives of 4-phenyl-4-oxobuten-2-oic acid and methods of treatment using them |
US4483868A (en) * | 1980-04-24 | 1984-11-20 | Roussel Uclaf | Gastro-protecting activity |
US4486429A (en) * | 1981-10-22 | 1984-12-04 | Roussel Uclaf | Amino derivatives of 4-phenyl 4-oxobuten-2-oic acid, pharmaceutical compositions containing them, and methods for preparing and therapeutically using them |
US4814348A (en) * | 1983-01-24 | 1989-03-21 | Roussel Uclaf | Therapeutic compositions containing derivatives of acrylic acid having an oxygen-containing heterocycle, therapeutic treatment therewith and new compounds |
US5886210A (en) * | 1996-08-22 | 1999-03-23 | Rohm And Haas Company | Method for preparing aromatic compounds |
WO2003097568A1 (en) * | 2002-05-15 | 2003-11-27 | Sankio Chemical Co., Ltd. | Process for producing 4-phenyl-4-oxo-2-butenoic ester derivative |
-
1978
- 1978-09-07 JP JP11006578A patent/JPS5536434A/en active Granted
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4483868A (en) * | 1980-04-24 | 1984-11-20 | Roussel Uclaf | Gastro-protecting activity |
US4454155A (en) * | 1981-10-22 | 1984-06-12 | Roussel Uclaf | Pharmaceutical compositions containing a mono-substituted derivative of 4-phenyl-4-oxobuten-2-oic acid, and methods of using them in treating gastric and gastroduodenal ailments |
US4473583A (en) * | 1981-10-22 | 1984-09-25 | Roussel Uclaf | Compositions containing certain derivatives of 4-phenyl-4-oxobuten-2-oic acid and methods of treatment using them |
US4486429A (en) * | 1981-10-22 | 1984-12-04 | Roussel Uclaf | Amino derivatives of 4-phenyl 4-oxobuten-2-oic acid, pharmaceutical compositions containing them, and methods for preparing and therapeutically using them |
US4814348A (en) * | 1983-01-24 | 1989-03-21 | Roussel Uclaf | Therapeutic compositions containing derivatives of acrylic acid having an oxygen-containing heterocycle, therapeutic treatment therewith and new compounds |
US5886210A (en) * | 1996-08-22 | 1999-03-23 | Rohm And Haas Company | Method for preparing aromatic compounds |
WO2003097568A1 (en) * | 2002-05-15 | 2003-11-27 | Sankio Chemical Co., Ltd. | Process for producing 4-phenyl-4-oxo-2-butenoic ester derivative |
US7161022B2 (en) | 2002-05-15 | 2007-01-09 | Fujifilm Finechemicals Co., Ltd. | Process for producing 4-phenyl-4-oxo-2-butenoic ester derivative |
KR101005969B1 (en) | 2002-05-15 | 2011-01-05 | 메이지 세이까 가부시끼가이샤 | Process for producing 4-phenyl-4-oxo-2-butenoic ester derivative |
Also Published As
Publication number | Publication date |
---|---|
JPS6116265B2 (en) | 1986-04-28 |
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