JPS5536434A - 4-phenyl-4-oxo-2-butenoic acid derivative and its preparation - Google Patents

4-phenyl-4-oxo-2-butenoic acid derivative and its preparation

Info

Publication number
JPS5536434A
JPS5536434A JP11006578A JP11006578A JPS5536434A JP S5536434 A JPS5536434 A JP S5536434A JP 11006578 A JP11006578 A JP 11006578A JP 11006578 A JP11006578 A JP 11006578A JP S5536434 A JPS5536434 A JP S5536434A
Authority
JP
Japan
Prior art keywords
halogen
oxo
phenyl
lower alkyl
butenoic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP11006578A
Other languages
Japanese (ja)
Other versions
JPS6116265B2 (en
Inventor
Teruomi Jojima
Hideo Takeshiba
Takao Otsu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Priority to JP11006578A priority Critical patent/JPS5536434A/en
Publication of JPS5536434A publication Critical patent/JPS5536434A/en
Publication of JPS6116265B2 publication Critical patent/JPS6116265B2/ja
Granted legal-status Critical Current

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

NEW MATERIAL:A 4-phenyl-4-oxo-2-butenoic acid derivative of formula I (R1 is H, OH or halogen; R2 and R4 are halogen, or one of them is halogen and other is H; R3 is H, lower alkyl, cycloalkyl, OH, halogen or a group II; R5 and R6 are H or lower alkyl; R7 is 1W3C lower alkyl).
EXAMPLE: 4-(3-Bromophenyl)-4-oxo-2-butenoic acid.
USE: An intermediate of a 6-phenyl-3(2H)pyridazinone derivative having wide antibacterial spectrum. An intermediate of a hypotensor.
PROCESS: A compound of formula III (R1' is H, etc; R2' and R4' are H, or one of them is halogen and the other is H; R3' is H, lower alkyl, etc.) is reacted with a sufficiently large amount of anhydrous aluminum chloride to form a complex compound; and the complex compound thus obtained is treated with a halogenating agent and decomposed with an acid to obtain the objective compound I.
COPYRIGHT: (C)1980,JPO&Japio
JP11006578A 1978-09-07 1978-09-07 4-phenyl-4-oxo-2-butenoic acid derivative and its preparation Granted JPS5536434A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP11006578A JPS5536434A (en) 1978-09-07 1978-09-07 4-phenyl-4-oxo-2-butenoic acid derivative and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP11006578A JPS5536434A (en) 1978-09-07 1978-09-07 4-phenyl-4-oxo-2-butenoic acid derivative and its preparation

Publications (2)

Publication Number Publication Date
JPS5536434A true JPS5536434A (en) 1980-03-14
JPS6116265B2 JPS6116265B2 (en) 1986-04-28

Family

ID=14526166

Family Applications (1)

Application Number Title Priority Date Filing Date
JP11006578A Granted JPS5536434A (en) 1978-09-07 1978-09-07 4-phenyl-4-oxo-2-butenoic acid derivative and its preparation

Country Status (1)

Country Link
JP (1) JPS5536434A (en)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4454155A (en) * 1981-10-22 1984-06-12 Roussel Uclaf Pharmaceutical compositions containing a mono-substituted derivative of 4-phenyl-4-oxobuten-2-oic acid, and methods of using them in treating gastric and gastroduodenal ailments
US4473583A (en) * 1981-10-22 1984-09-25 Roussel Uclaf Compositions containing certain derivatives of 4-phenyl-4-oxobuten-2-oic acid and methods of treatment using them
US4483868A (en) * 1980-04-24 1984-11-20 Roussel Uclaf Gastro-protecting activity
US4486429A (en) * 1981-10-22 1984-12-04 Roussel Uclaf Amino derivatives of 4-phenyl 4-oxobuten-2-oic acid, pharmaceutical compositions containing them, and methods for preparing and therapeutically using them
US4814348A (en) * 1983-01-24 1989-03-21 Roussel Uclaf Therapeutic compositions containing derivatives of acrylic acid having an oxygen-containing heterocycle, therapeutic treatment therewith and new compounds
US5886210A (en) * 1996-08-22 1999-03-23 Rohm And Haas Company Method for preparing aromatic compounds
WO2003097568A1 (en) * 2002-05-15 2003-11-27 Sankio Chemical Co., Ltd. Process for producing 4-phenyl-4-oxo-2-butenoic ester derivative

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4483868A (en) * 1980-04-24 1984-11-20 Roussel Uclaf Gastro-protecting activity
US4454155A (en) * 1981-10-22 1984-06-12 Roussel Uclaf Pharmaceutical compositions containing a mono-substituted derivative of 4-phenyl-4-oxobuten-2-oic acid, and methods of using them in treating gastric and gastroduodenal ailments
US4473583A (en) * 1981-10-22 1984-09-25 Roussel Uclaf Compositions containing certain derivatives of 4-phenyl-4-oxobuten-2-oic acid and methods of treatment using them
US4486429A (en) * 1981-10-22 1984-12-04 Roussel Uclaf Amino derivatives of 4-phenyl 4-oxobuten-2-oic acid, pharmaceutical compositions containing them, and methods for preparing and therapeutically using them
US4814348A (en) * 1983-01-24 1989-03-21 Roussel Uclaf Therapeutic compositions containing derivatives of acrylic acid having an oxygen-containing heterocycle, therapeutic treatment therewith and new compounds
US5886210A (en) * 1996-08-22 1999-03-23 Rohm And Haas Company Method for preparing aromatic compounds
WO2003097568A1 (en) * 2002-05-15 2003-11-27 Sankio Chemical Co., Ltd. Process for producing 4-phenyl-4-oxo-2-butenoic ester derivative
US7161022B2 (en) 2002-05-15 2007-01-09 Fujifilm Finechemicals Co., Ltd. Process for producing 4-phenyl-4-oxo-2-butenoic ester derivative
KR101005969B1 (en) 2002-05-15 2011-01-05 메이지 세이까 가부시끼가이샤 Process for producing 4-phenyl-4-oxo-2-butenoic ester derivative

Also Published As

Publication number Publication date
JPS6116265B2 (en) 1986-04-28

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