JPS5524124A - 5-fluorouracil derivative and its preparation - Google Patents
5-fluorouracil derivative and its preparationInfo
- Publication number
- JPS5524124A JPS5524124A JP9672578A JP9672578A JPS5524124A JP S5524124 A JPS5524124 A JP S5524124A JP 9672578 A JP9672578 A JP 9672578A JP 9672578 A JP9672578 A JP 9672578A JP S5524124 A JPS5524124 A JP S5524124A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- preparation
- fluorouracil
- fluorouracil derivative
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:A compound of formula I [R1 and R2 are H, -CH2SR3(R3 is alkyl or aryl group which may be substituted), however, both R1 and R2 are not H].
EXAMPLE: 1-Methylthiomethyl-5-fluorouracil.
USE: Carcinostatics effective against mouse leukemia L-1210.
PROCESS: 5-Fluoro-2,4-bis-trimethyl-silyloxypyrimidine is reacted with a chloride of the formula Cl-CH2SR3 in the presence of an acid catalyst, e.g. SnCl4, iron chloride, TiCl4,or AlCl3 at room temperature to 120°C, e.g. 70°C for 1hr, to give the objective compound of formula I.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP9672578A JPS5524124A (en) | 1978-08-10 | 1978-08-10 | 5-fluorouracil derivative and its preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP9672578A JPS5524124A (en) | 1978-08-10 | 1978-08-10 | 5-fluorouracil derivative and its preparation |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5524124A true JPS5524124A (en) | 1980-02-21 |
JPS6111226B2 JPS6111226B2 (en) | 1986-04-01 |
Family
ID=14172702
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP9672578A Granted JPS5524124A (en) | 1978-08-10 | 1978-08-10 | 5-fluorouracil derivative and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5524124A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1989010361A1 (en) * | 1988-04-27 | 1989-11-02 | Kyowa Hakko Kogyo Co., Ltd. | Novel compound and medicine containing same |
-
1978
- 1978-08-10 JP JP9672578A patent/JPS5524124A/en active Granted
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1989010361A1 (en) * | 1988-04-27 | 1989-11-02 | Kyowa Hakko Kogyo Co., Ltd. | Novel compound and medicine containing same |
Also Published As
Publication number | Publication date |
---|---|
JPS6111226B2 (en) | 1986-04-01 |
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