JPS55118494A - Novel phosphorylcholine compound, its preparation, and antitumor agent comprising it - Google Patents
Novel phosphorylcholine compound, its preparation, and antitumor agent comprising itInfo
- Publication number
- JPS55118494A JPS55118494A JP2564379A JP2564379A JPS55118494A JP S55118494 A JPS55118494 A JP S55118494A JP 2564379 A JP2564379 A JP 2564379A JP 2564379 A JP2564379 A JP 2564379A JP S55118494 A JPS55118494 A JP S55118494A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- preparation
- antitumor agent
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
NEW MATERIAL:A phosphorylcholine compound of formula I (R1 and R2 are H, alkyl groups, etc.; R3 and R5 are H, COOH groups, etc.; R4 is H, alkyl group, etc.; A is O, S, etc.; R6 is H, alkyl group, etc.; R7 is alkyl or aralkyl group; X1 and X2 are O or S; l and m are 0, 1, or 2; n is 2 or 3), its salt, and hydrate.
EXAMPLE: 2-( N-Cetyl-N-chloroacetylamino )ethanol-2'-trimethylammoniumethyl phosphate.
USE: Antitumor agents and immune activators, particularly effective against solid cancers, administrable from a distant site.
PROCESS: A compound of formula II is reacted with a compound of formula III (Y1 and Y2 are halogens) to give a compound of formula IV, which is hydrolyzed, reacted with an amine of the formula N(R7)3, and dehydrohalogenated to form the compound of formula I.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2564379A JPS55118494A (en) | 1979-03-07 | 1979-03-07 | Novel phosphorylcholine compound, its preparation, and antitumor agent comprising it |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2564379A JPS55118494A (en) | 1979-03-07 | 1979-03-07 | Novel phosphorylcholine compound, its preparation, and antitumor agent comprising it |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS55118494A true JPS55118494A (en) | 1980-09-11 |
JPS6252757B2 JPS6252757B2 (en) | 1987-11-06 |
Family
ID=12171506
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2564379A Granted JPS55118494A (en) | 1979-03-07 | 1979-03-07 | Novel phosphorylcholine compound, its preparation, and antitumor agent comprising it |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS55118494A (en) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0050327A1 (en) * | 1980-10-21 | 1982-04-28 | Roche Diagnostics GmbH | Phospholipids that contain sulphur, process for their preparation and medicines containing these compounds |
EP0208961A2 (en) * | 1985-07-01 | 1987-01-21 | Merck & Co. Inc. | Phospholipid analogs useful as paf synthesis inhibitors |
JP2003526614A (en) * | 1999-03-16 | 2003-09-09 | アーデニア・インベストメンツ・リミテッド | Polyunsaturated fatty acid derivatives and uses thereof |
WO2021195548A1 (en) * | 2020-03-27 | 2021-09-30 | Travecta Therapeutics, Pte. Ltd. | Oleoylethanolamide compounds |
WO2021195555A1 (en) * | 2020-03-27 | 2021-09-30 | Travecta Therapeutics, Pte. Ltd. | Palmitoylethanolamide compounds |
-
1979
- 1979-03-07 JP JP2564379A patent/JPS55118494A/en active Granted
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0050327A1 (en) * | 1980-10-21 | 1982-04-28 | Roche Diagnostics GmbH | Phospholipids that contain sulphur, process for their preparation and medicines containing these compounds |
EP0208961A2 (en) * | 1985-07-01 | 1987-01-21 | Merck & Co. Inc. | Phospholipid analogs useful as paf synthesis inhibitors |
EP0208961A3 (en) * | 1985-07-01 | 1988-04-20 | Merck & Co. Inc. | Phospholipid analogs useful as paf synthesis inhibitors |
JP2003526614A (en) * | 1999-03-16 | 2003-09-09 | アーデニア・インベストメンツ・リミテッド | Polyunsaturated fatty acid derivatives and uses thereof |
WO2021195548A1 (en) * | 2020-03-27 | 2021-09-30 | Travecta Therapeutics, Pte. Ltd. | Oleoylethanolamide compounds |
WO2021195555A1 (en) * | 2020-03-27 | 2021-09-30 | Travecta Therapeutics, Pte. Ltd. | Palmitoylethanolamide compounds |
Also Published As
Publication number | Publication date |
---|---|
JPS6252757B2 (en) | 1987-11-06 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES8207156A1 (en) | Pyrimidones, their preparation and medicines containing them. | |
UA7228A1 (en) | Method for synthesizing derivatives of n-(4-indolylpiperidine alkyl) benzimidazolon or their salts | |
JPS56131565A (en) | 4-substituted-2-oxoazetidine compound and its preparation | |
JPS5791997A (en) | 5'-o-acylnucleoside and its preparation | |
JPS56103168A (en) | Thiazole derivative, its preparation, and antihistaminic agent containing the same | |
JPS55118494A (en) | Novel phosphorylcholine compound, its preparation, and antitumor agent comprising it | |
AU579116B2 (en) | Use of quinoline derivatives for the protection of cultivated plants | |
JPS57169478A (en) | Piperazine derivative | |
JPS54128591A (en) | Cephalosporin analog | |
ES8603434A1 (en) | 1,2,4-Triazolylpropanols, and their production and use. | |
ES8504829A1 (en) | Alpha-hydroxy-beta-haloethylphosphinic acids and their salts, and their production and use. | |
JPS5625195A (en) | 2-dialkylaminoquinazoline derivative | |
JPS5520740A (en) | Aminoalkoxybibenzyl and its acid addition salt | |
JPS55129299A (en) | 1-beta-d-arabinofuranosyl-cytosine-5'-phosphoric alkyl ester | |
JPS55162758A (en) | Novel phenylacetamide derivative | |
JPS57154183A (en) | Omega-piperazinylalkanoylalkylene dioxybenzenes and their acid addition salts | |
JPS56115792A (en) | Novel phosphorus compound and antitumor agent containing the same | |
JPS5511503A (en) | Condensed heterocyclic compound | |
JPS5711975A (en) | Aminophenyltetrazole derivative and salt thereof | |
JPS567782A (en) | Novel pyridinecarboxamide derivative and its preparation | |
JPS57171983A (en) | Aminophenyltetrazole derivative and salt thereof | |
ES8506035A1 (en) | Bis-alkylphosphonium salts of N-phosphonomethyglycine. | |
JPS57176979A (en) | Novel derivative of secalonic acid and its preparation | |
JPS5799584A (en) | (omega-aminoalkoxy)alkylenedioxybenzenes and their acid addition salts | |
JPS56128787A (en) | Cephalosporin derivative and its preparation |