JPS55118494A - Novel phosphorylcholine compound, its preparation, and antitumor agent comprising it - Google Patents

Novel phosphorylcholine compound, its preparation, and antitumor agent comprising it

Info

Publication number
JPS55118494A
JPS55118494A JP2564379A JP2564379A JPS55118494A JP S55118494 A JPS55118494 A JP S55118494A JP 2564379 A JP2564379 A JP 2564379A JP 2564379 A JP2564379 A JP 2564379A JP S55118494 A JPS55118494 A JP S55118494A
Authority
JP
Japan
Prior art keywords
compound
formula
preparation
antitumor agent
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2564379A
Other languages
Japanese (ja)
Other versions
JPS6252757B2 (en
Inventor
Hiroshi Kodama
Masao Nakabayashi
Yoshifumi Nakajima
Takashi Nagai
Mikio Kawabata
Isao Myokan
Tetsuya Kajita
Masaaki Shibata
Kiyoshi Goda
Takashi Sano
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toyama Chemical Co Ltd
Original Assignee
Toyama Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toyama Chemical Co Ltd filed Critical Toyama Chemical Co Ltd
Priority to JP2564379A priority Critical patent/JPS55118494A/en
Publication of JPS55118494A publication Critical patent/JPS55118494A/en
Publication of JPS6252757B2 publication Critical patent/JPS6252757B2/ja
Granted legal-status Critical Current

Links

Abstract

NEW MATERIAL:A phosphorylcholine compound of formula I (R1 and R2 are H, alkyl groups, etc.; R3 and R5 are H, COOH groups, etc.; R4 is H, alkyl group, etc.; A is O, S, etc.; R6 is H, alkyl group, etc.; R7 is alkyl or aralkyl group; X1 and X2 are O or S; l and m are 0, 1, or 2; n is 2 or 3), its salt, and hydrate.
EXAMPLE: 2-( N-Cetyl-N-chloroacetylamino )ethanol-2'-trimethylammoniumethyl phosphate.
USE: Antitumor agents and immune activators, particularly effective against solid cancers, administrable from a distant site.
PROCESS: A compound of formula II is reacted with a compound of formula III (Y1 and Y2 are halogens) to give a compound of formula IV, which is hydrolyzed, reacted with an amine of the formula N(R7)3, and dehydrohalogenated to form the compound of formula I.
COPYRIGHT: (C)1980,JPO&Japio
JP2564379A 1979-03-07 1979-03-07 Novel phosphorylcholine compound, its preparation, and antitumor agent comprising it Granted JPS55118494A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2564379A JPS55118494A (en) 1979-03-07 1979-03-07 Novel phosphorylcholine compound, its preparation, and antitumor agent comprising it

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2564379A JPS55118494A (en) 1979-03-07 1979-03-07 Novel phosphorylcholine compound, its preparation, and antitumor agent comprising it

Publications (2)

Publication Number Publication Date
JPS55118494A true JPS55118494A (en) 1980-09-11
JPS6252757B2 JPS6252757B2 (en) 1987-11-06

Family

ID=12171506

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2564379A Granted JPS55118494A (en) 1979-03-07 1979-03-07 Novel phosphorylcholine compound, its preparation, and antitumor agent comprising it

Country Status (1)

Country Link
JP (1) JPS55118494A (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0050327A1 (en) * 1980-10-21 1982-04-28 Roche Diagnostics GmbH Phospholipids that contain sulphur, process for their preparation and medicines containing these compounds
EP0208961A2 (en) * 1985-07-01 1987-01-21 Merck & Co. Inc. Phospholipid analogs useful as paf synthesis inhibitors
JP2003526614A (en) * 1999-03-16 2003-09-09 アーデニア・インベストメンツ・リミテッド Polyunsaturated fatty acid derivatives and uses thereof
WO2021195548A1 (en) * 2020-03-27 2021-09-30 Travecta Therapeutics, Pte. Ltd. Oleoylethanolamide compounds
WO2021195555A1 (en) * 2020-03-27 2021-09-30 Travecta Therapeutics, Pte. Ltd. Palmitoylethanolamide compounds

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0050327A1 (en) * 1980-10-21 1982-04-28 Roche Diagnostics GmbH Phospholipids that contain sulphur, process for their preparation and medicines containing these compounds
EP0208961A2 (en) * 1985-07-01 1987-01-21 Merck & Co. Inc. Phospholipid analogs useful as paf synthesis inhibitors
EP0208961A3 (en) * 1985-07-01 1988-04-20 Merck & Co. Inc. Phospholipid analogs useful as paf synthesis inhibitors
JP2003526614A (en) * 1999-03-16 2003-09-09 アーデニア・インベストメンツ・リミテッド Polyunsaturated fatty acid derivatives and uses thereof
WO2021195548A1 (en) * 2020-03-27 2021-09-30 Travecta Therapeutics, Pte. Ltd. Oleoylethanolamide compounds
WO2021195555A1 (en) * 2020-03-27 2021-09-30 Travecta Therapeutics, Pte. Ltd. Palmitoylethanolamide compounds

Also Published As

Publication number Publication date
JPS6252757B2 (en) 1987-11-06

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