JPS55129299A - 1-beta-d-arabinofuranosyl-cytosine-5'-phosphoric alkyl ester - Google Patents

1-beta-d-arabinofuranosyl-cytosine-5'-phosphoric alkyl ester

Info

Publication number
JPS55129299A
JPS55129299A JP3163780A JP3163780A JPS55129299A JP S55129299 A JPS55129299 A JP S55129299A JP 3163780 A JP3163780 A JP 3163780A JP 3163780 A JP3163780 A JP 3163780A JP S55129299 A JPS55129299 A JP S55129299A
Authority
JP
Japan
Prior art keywords
arabinofuranosyl
cytosine
ara
cmp
beta
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP3163780A
Other languages
Japanese (ja)
Other versions
JPS5640720B2 (en
Inventor
Masami Morozumi
Morio Suzuki
Hiroshi Yoshino
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yamasa Shoyu KK
Original Assignee
Yamasa Shoyu KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamasa Shoyu KK filed Critical Yamasa Shoyu KK
Priority to JP3163780A priority Critical patent/JPS55129299A/en
Publication of JPS55129299A publication Critical patent/JPS55129299A/en
Publication of JPS5640720B2 publication Critical patent/JPS5640720B2/ja
Granted legal-status Critical Current

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  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:The title compound of the formula (R is ≥14C alkyl group).
USE: Antitumor agents.
PROCESS: 1-β-D-Arabinofuranosyl-cytosine-5'-phosphoric acid (ara-CMP), preferably in the form of triethylammonium salt, is dissolved in an organic solvent, e.g. N,N'-dimethylformamide, which will not inhibit the reaction, and dissolved in a 14W23C alcohol, e.g. tetradecanol or stearyl alcohol, preferably in a molar amount of 2W4 times that of ara-CMP at room temperature for 1W24hr. The organic solvent is used in an amount of 1W10ml per m mole of the ara-CMP.
COPYRIGHT: (C)1980,JPO&Japio
JP3163780A 1980-03-14 1980-03-14 1-beta-d-arabinofuranosyl-cytosine-5'-phosphoric alkyl ester Granted JPS55129299A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP3163780A JPS55129299A (en) 1980-03-14 1980-03-14 1-beta-d-arabinofuranosyl-cytosine-5'-phosphoric alkyl ester

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP3163780A JPS55129299A (en) 1980-03-14 1980-03-14 1-beta-d-arabinofuranosyl-cytosine-5'-phosphoric alkyl ester

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP546176A Division JPS5289681A (en) 1976-01-22 1976-01-22 Preparation of aracytidine -5# phosphoric acid ester derivatives

Publications (2)

Publication Number Publication Date
JPS55129299A true JPS55129299A (en) 1980-10-06
JPS5640720B2 JPS5640720B2 (en) 1981-09-22

Family

ID=12336720

Family Applications (1)

Application Number Title Priority Date Filing Date
JP3163780A Granted JPS55129299A (en) 1980-03-14 1980-03-14 1-beta-d-arabinofuranosyl-cytosine-5'-phosphoric alkyl ester

Country Status (1)

Country Link
JP (1) JPS55129299A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58225097A (en) * 1982-06-23 1983-12-27 Yamasa Shoyu Co Ltd Nucleoside 5'-alkyl or alkenylphosphate
JPS5948498A (en) * 1982-09-11 1984-03-19 Yamasa Shoyu Co Ltd 1-beta-d-arabinofuranosylcytosine-5'-phosphoric acid derivative
US4812560A (en) * 1986-03-24 1989-03-14 Yamasa Shoyu Kabushiki Kaisha Process for producing 1-β-D-arabinofuranosylcytosine-5'-stearylphosphate monosodium salt and monohydrate thereof

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58225097A (en) * 1982-06-23 1983-12-27 Yamasa Shoyu Co Ltd Nucleoside 5'-alkyl or alkenylphosphate
JPH0136838B2 (en) * 1982-06-23 1989-08-02 Yamasa Shoyu Kk
JPS5948498A (en) * 1982-09-11 1984-03-19 Yamasa Shoyu Co Ltd 1-beta-d-arabinofuranosylcytosine-5'-phosphoric acid derivative
JPH0310639B2 (en) * 1982-09-11 1991-02-14 Yamasa Shoyu Kk
US4812560A (en) * 1986-03-24 1989-03-14 Yamasa Shoyu Kabushiki Kaisha Process for producing 1-β-D-arabinofuranosylcytosine-5'-stearylphosphate monosodium salt and monohydrate thereof
US5049663A (en) * 1986-03-24 1991-09-17 Nippon Kayaku Kabushiki Kaisha Process for producing 1-β-D-arabinofuranosylcytosine-5'-stearylphosphate monosodium salt and monohydrate thereof

Also Published As

Publication number Publication date
JPS5640720B2 (en) 1981-09-22

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