JPS55129299A - 1-beta-d-arabinofuranosyl-cytosine-5'-phosphoric alkyl ester - Google Patents
1-beta-d-arabinofuranosyl-cytosine-5'-phosphoric alkyl esterInfo
- Publication number
- JPS55129299A JPS55129299A JP3163780A JP3163780A JPS55129299A JP S55129299 A JPS55129299 A JP S55129299A JP 3163780 A JP3163780 A JP 3163780A JP 3163780 A JP3163780 A JP 3163780A JP S55129299 A JPS55129299 A JP S55129299A
- Authority
- JP
- Japan
- Prior art keywords
- arabinofuranosyl
- cytosine
- ara
- cmp
- beta
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:The title compound of the formula (R is ≥14C alkyl group).
USE: Antitumor agents.
PROCESS: 1-β-D-Arabinofuranosyl-cytosine-5'-phosphoric acid (ara-CMP), preferably in the form of triethylammonium salt, is dissolved in an organic solvent, e.g. N,N'-dimethylformamide, which will not inhibit the reaction, and dissolved in a 14W23C alcohol, e.g. tetradecanol or stearyl alcohol, preferably in a molar amount of 2W4 times that of ara-CMP at room temperature for 1W24hr. The organic solvent is used in an amount of 1W10ml per m mole of the ara-CMP.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP3163780A JPS55129299A (en) | 1980-03-14 | 1980-03-14 | 1-beta-d-arabinofuranosyl-cytosine-5'-phosphoric alkyl ester |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP3163780A JPS55129299A (en) | 1980-03-14 | 1980-03-14 | 1-beta-d-arabinofuranosyl-cytosine-5'-phosphoric alkyl ester |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP546176A Division JPS5289681A (en) | 1976-01-22 | 1976-01-22 | Preparation of aracytidine -5# phosphoric acid ester derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS55129299A true JPS55129299A (en) | 1980-10-06 |
JPS5640720B2 JPS5640720B2 (en) | 1981-09-22 |
Family
ID=12336720
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP3163780A Granted JPS55129299A (en) | 1980-03-14 | 1980-03-14 | 1-beta-d-arabinofuranosyl-cytosine-5'-phosphoric alkyl ester |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS55129299A (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS58225097A (en) * | 1982-06-23 | 1983-12-27 | Yamasa Shoyu Co Ltd | Nucleoside 5'-alkyl or alkenylphosphate |
JPS5948498A (en) * | 1982-09-11 | 1984-03-19 | Yamasa Shoyu Co Ltd | 1-beta-d-arabinofuranosylcytosine-5'-phosphoric acid derivative |
US4812560A (en) * | 1986-03-24 | 1989-03-14 | Yamasa Shoyu Kabushiki Kaisha | Process for producing 1-β-D-arabinofuranosylcytosine-5'-stearylphosphate monosodium salt and monohydrate thereof |
-
1980
- 1980-03-14 JP JP3163780A patent/JPS55129299A/en active Granted
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS58225097A (en) * | 1982-06-23 | 1983-12-27 | Yamasa Shoyu Co Ltd | Nucleoside 5'-alkyl or alkenylphosphate |
JPH0136838B2 (en) * | 1982-06-23 | 1989-08-02 | Yamasa Shoyu Kk | |
JPS5948498A (en) * | 1982-09-11 | 1984-03-19 | Yamasa Shoyu Co Ltd | 1-beta-d-arabinofuranosylcytosine-5'-phosphoric acid derivative |
JPH0310639B2 (en) * | 1982-09-11 | 1991-02-14 | Yamasa Shoyu Kk | |
US4812560A (en) * | 1986-03-24 | 1989-03-14 | Yamasa Shoyu Kabushiki Kaisha | Process for producing 1-β-D-arabinofuranosylcytosine-5'-stearylphosphate monosodium salt and monohydrate thereof |
US5049663A (en) * | 1986-03-24 | 1991-09-17 | Nippon Kayaku Kabushiki Kaisha | Process for producing 1-β-D-arabinofuranosylcytosine-5'-stearylphosphate monosodium salt and monohydrate thereof |
Also Published As
Publication number | Publication date |
---|---|
JPS5640720B2 (en) | 1981-09-22 |
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