JPS5520740A - Aminoalkoxybibenzyl and its acid addition salt - Google Patents
Aminoalkoxybibenzyl and its acid addition saltInfo
- Publication number
- JPS5520740A JPS5520740A JP9404478A JP9404478A JPS5520740A JP S5520740 A JPS5520740 A JP S5520740A JP 9404478 A JP9404478 A JP 9404478A JP 9404478 A JP9404478 A JP 9404478A JP S5520740 A JPS5520740 A JP S5520740A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- group
- substituted
- aminoalkoxybibenzyl
- acid addition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
NEW MATERIAL:An aminoalkoxybibenzyl of formula I: [R1 is formula II or III (n is an integer 2W7); heterocyclic group may be substituted by a group selected from R4, COOR5, and hydroxyl group, or the methylene group forming the heterocyclic group may be substituted by formula IV; m is an integer 2W8; formula V is benzene ring which may be substituted by halogen, R9, etc.; R2, R3, and R8 are H or 1W3C alkyl groups; R5 is H or 1W8C alkyl group; R4 and R9 are 1W8C alkyl groups], and its acid addition salt.
EXAMPLE: 2-(2-Dimethylaminoethoxy)-4'-chlorobibenzyl.
USE: Useful as remedies or preventives aginst thrombosis, having an anticoagulating action, particularly blood platelet antiagglutinating action.
PROCESS: One mole of a halogenoalkoxybibenzyl of formula VI: (X is halogen) is reacted with 1W100 moles of an amine of the formula R1-H to give the compound of formula I.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (17)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP9404478A JPS5520740A (en) | 1978-08-01 | 1978-08-01 | Aminoalkoxybibenzyl and its acid addition salt |
US05/943,621 US4220603A (en) | 1977-10-07 | 1978-09-19 | Pharmaceutically active (omega-aminoalkoxy)bibenzyls |
CA311,866A CA1105931A (en) | 1977-10-07 | 1978-09-22 | Pharmaceutically active (omega-aminoalkoxy) bibenzyls |
HU78MI636A HU178306B (en) | 1977-10-07 | 1978-10-03 | Process for preparing pharmaceutically active /omega-amino-alkoxy/-dibenzyl derivatives and acid addition salts thereof |
DK441878A DK152040C (en) | 1977-10-07 | 1978-10-04 | ANALOGY PROCEDURE FOR PREPARING BIBENZYL DERIVATIVES OR ACID ADDITION SALTS |
DD78208291A DD139255A5 (en) | 1977-10-07 | 1978-10-05 | METHOD FOR THE PRODUCTION OF (OMEGA-AMINOALKOXY) -BIBENZYLENE AND ITS SAEUREADDITIONAL SALTS |
ES474575A ES474575A1 (en) | 1977-10-07 | 1978-10-06 | (Omega-aminoalkoxy) bibenzyls, processes for their preparation and pharmaceutical compositions containing these substances. |
SU782668855A SU786883A3 (en) | 1977-10-07 | 1978-10-06 | Method of preparing (omega-aminoalkoxy)-bibenzyls or their salts |
IT28531/78A IT1099778B (en) | 1977-10-07 | 1978-10-06 | (OMEGA-AMMINOLACOSSI) PHARMACEUTICALLY ACTIVE BONDS |
FI783049A FI69840C (en) | 1977-10-07 | 1978-10-06 | FRUIT PROCESSING OF PHARMACEUTICAL ACTIVITIES (OMEGA-AMINOALCOXY) -DIBENYL DERIVATIVES |
DE7878101092T DE2861477D1 (en) | 1977-10-07 | 1978-10-06 | (omega-aminoalkoxy) bibenzyls, processes for their preparation and pharmaceutical compositions containing these substances |
NO78783399A NO146744C (en) | 1977-10-07 | 1978-10-06 | ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVITY (OMEGA-AMINOALCOXY) -DIBENZYL DERIVATIVES |
EP78101092A EP0001759B1 (en) | 1977-10-07 | 1978-10-06 | (omega-aminoalkoxy) bibenzyls, processes for their preparation and pharmaceutical compositions containing these substances |
CS786561A CS209918B2 (en) | 1977-10-07 | 1978-10-09 | Method of preparation of the (omega-aminoalcoxy) bibenzyles |
ES480091A ES480091A1 (en) | 1977-10-07 | 1979-04-30 | (Omega-aminoalkoxy) bibenzyls, processes for their preparation and pharmaceutical compositions containing these substances. |
CS794084A CS209917B2 (en) | 1977-10-07 | 1979-06-13 | Method of preparation of the /omega-aminoalkoxy/bibenzyles |
US06/100,741 US4323568A (en) | 1977-10-07 | 1979-12-06 | Pharmaceutically active (omega-aminoalkoxy)bibenzyls |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP9404478A JPS5520740A (en) | 1978-08-01 | 1978-08-01 | Aminoalkoxybibenzyl and its acid addition salt |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5520740A true JPS5520740A (en) | 1980-02-14 |
JPS6121463B2 JPS6121463B2 (en) | 1986-05-27 |
Family
ID=14099557
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP9404478A Granted JPS5520740A (en) | 1977-10-07 | 1978-08-01 | Aminoalkoxybibenzyl and its acid addition salt |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5520740A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH02304022A (en) * | 1989-05-18 | 1990-12-17 | Mitsubishi Kasei Corp | Serotonin antagonistic agent |
EP0600717A1 (en) | 1992-11-30 | 1994-06-08 | Sankyo Company Limited | Phenoxyalkylamines, -pyrrolidines and -piperidines for the treatment and prevention of circulatory diseases and psychosis |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6447372U (en) * | 1987-09-17 | 1989-03-23 |
-
1978
- 1978-08-01 JP JP9404478A patent/JPS5520740A/en active Granted
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH02304022A (en) * | 1989-05-18 | 1990-12-17 | Mitsubishi Kasei Corp | Serotonin antagonistic agent |
JPH0544926B2 (en) * | 1989-05-18 | 1993-07-07 | Mitsubishi Chem Ind | |
EP0600717A1 (en) | 1992-11-30 | 1994-06-08 | Sankyo Company Limited | Phenoxyalkylamines, -pyrrolidines and -piperidines for the treatment and prevention of circulatory diseases and psychosis |
Also Published As
Publication number | Publication date |
---|---|
JPS6121463B2 (en) | 1986-05-27 |
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