JPS5528916A - 5-fluorouracil derivative and its preparation - Google Patents

5-fluorouracil derivative and its preparation

Info

Publication number
JPS5528916A
JPS5528916A JP10126578A JP10126578A JPS5528916A JP S5528916 A JPS5528916 A JP S5528916A JP 10126578 A JP10126578 A JP 10126578A JP 10126578 A JP10126578 A JP 10126578A JP S5528916 A JPS5528916 A JP S5528916A
Authority
JP
Japan
Prior art keywords
formula
fluorouracil
group
preparation
fluorouracil derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP10126578A
Other languages
Japanese (ja)
Inventor
Kazumi Inoue
Tameo Iwasaki
Takashi Nishitani
Hiroshi Horikawa
Yoshihisa Arai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tanabe Seiyaku Co Ltd
Original Assignee
Tanabe Seiyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanabe Seiyaku Co Ltd filed Critical Tanabe Seiyaku Co Ltd
Priority to JP10126578A priority Critical patent/JPS5528916A/en
Publication of JPS5528916A publication Critical patent/JPS5528916A/en
Pending legal-status Critical Current

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  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A 5-fluorouracil derivative of formula I:(R is H, 1W20C alkyl, or 7W10C aralkyl group; A is lower alkylene group).
EXAMPLE: 1-(2-Pyrrolidon-5-yl)-5-fluorouracil.
USE: Medicines having antitumor actions.
PROCESS: A 2,4-bistrimethyl silyl-5-fluoro-uracil of formula II: (R' is trimethyl silyl group) is reacted with a lactam of formula III: (X is lower alkoxy group) in the presence of a lewis acid, e.g. tin tetra chloride, to give the objective compound of formula I.
COPYRIGHT: (C)1980,JPO&Japio
JP10126578A 1978-08-18 1978-08-18 5-fluorouracil derivative and its preparation Pending JPS5528916A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP10126578A JPS5528916A (en) 1978-08-18 1978-08-18 5-fluorouracil derivative and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP10126578A JPS5528916A (en) 1978-08-18 1978-08-18 5-fluorouracil derivative and its preparation

Publications (1)

Publication Number Publication Date
JPS5528916A true JPS5528916A (en) 1980-02-29

Family

ID=14296061

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10126578A Pending JPS5528916A (en) 1978-08-18 1978-08-18 5-fluorouracil derivative and its preparation

Country Status (1)

Country Link
JP (1) JPS5528916A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63278B2 (en) * 1983-02-25 1988-01-06 Hikari Kogyo Kk

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63278B2 (en) * 1983-02-25 1988-01-06 Hikari Kogyo Kk

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