JPS5528916A - 5-fluorouracil derivative and its preparation - Google Patents
5-fluorouracil derivative and its preparationInfo
- Publication number
- JPS5528916A JPS5528916A JP10126578A JP10126578A JPS5528916A JP S5528916 A JPS5528916 A JP S5528916A JP 10126578 A JP10126578 A JP 10126578A JP 10126578 A JP10126578 A JP 10126578A JP S5528916 A JPS5528916 A JP S5528916A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- fluorouracil
- group
- preparation
- fluorouracil derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:A 5-fluorouracil derivative of formula I:(R is H, 1W20C alkyl, or 7W10C aralkyl group; A is lower alkylene group).
EXAMPLE: 1-(2-Pyrrolidon-5-yl)-5-fluorouracil.
USE: Medicines having antitumor actions.
PROCESS: A 2,4-bistrimethyl silyl-5-fluoro-uracil of formula II: (R' is trimethyl silyl group) is reacted with a lactam of formula III: (X is lower alkoxy group) in the presence of a lewis acid, e.g. tin tetra chloride, to give the objective compound of formula I.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10126578A JPS5528916A (en) | 1978-08-18 | 1978-08-18 | 5-fluorouracil derivative and its preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10126578A JPS5528916A (en) | 1978-08-18 | 1978-08-18 | 5-fluorouracil derivative and its preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5528916A true JPS5528916A (en) | 1980-02-29 |
Family
ID=14296061
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP10126578A Pending JPS5528916A (en) | 1978-08-18 | 1978-08-18 | 5-fluorouracil derivative and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5528916A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS63278B2 (en) * | 1983-02-25 | 1988-01-06 | Hikari Kogyo Kk |
-
1978
- 1978-08-18 JP JP10126578A patent/JPS5528916A/en active Pending
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS63278B2 (en) * | 1983-02-25 | 1988-01-06 | Hikari Kogyo Kk |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
FR2417502A1 (en) | NEW SUBSTITUTED 2-PHENYLIMINO-IMIDAZOLIDINES, THEIR ADDITIONAL SALTS WITH ACIDS, MEDICINAL PRODUCTS CONTAINING THEM AND METHODS FOR THEIR PREPARATION | |
IE791884L (en) | 4-phenyl-1,3 benzodiazepines | |
FR2417503A1 (en) | NEW SUBSTITUTED 2-PHENYLIMINO-IMIDAZOLIDINES, THEIR ADDITIONAL SALTS WITH ACIDS, MEDICINAL PRODUCTS CONTAINING THEM AND METHODS FOR THEIR PREPARATION | |
JPS5528916A (en) | 5-fluorouracil derivative and its preparation | |
ES8104222A1 (en) | Alkylcarbapenems, their preparation, use in pharmaceutical compositions and intermediates. | |
FR2377382A1 (en) | NEW PHENYLAZACYCLOALCANES USEFUL AS MEDICINAL PRODUCTS | |
EP0266956A3 (en) | Azulene derivatives and pharmaceutical compositions containing them | |
JPS5576872A (en) | Imidazolidinone derivative | |
JPS55118494A (en) | Novel phosphorylcholine compound, its preparation, and antitumor agent comprising it | |
JPS5711981A (en) | Theobromine derivative and its preparation | |
MY103523A (en) | Chemical process and intermediates | |
ES8608315A1 (en) | Soporific comprising lorazepam. | |
JPS5732270A (en) | Preparation of 3-substituted-5-halogenated uracil | |
JPS5770854A (en) | N,n-dialkyl carbamate | |
JPS55157574A (en) | 5-fluorouracyl derivative and its preparation | |
JPS55153796A (en) | 5-fluorouracil nucleoside and its preparation | |
JPS5753469A (en) | 5-fluorouracil derivative, its preparation and use | |
JPS5524124A (en) | 5-fluorouracil derivative and its preparation | |
JPS5576866A (en) | Preparation of 5-fluorouracil derivative | |
JPS5479289A (en) | Uracil derivative and its preparation | |
JPS5759876A (en) | Novel 5-fluorouracil derivative | |
JPS5481281A (en) | Preparation of uracil derivative | |
JPS5711975A (en) | Aminophenyltetrazole derivative and salt thereof | |
JPS57169458A (en) | Preparation of indole derivative | |
JPS5625166A (en) | 5-fluorouracil derivative |