JPS5481281A - Preparation of uracil derivative - Google Patents
Preparation of uracil derivativeInfo
- Publication number
- JPS5481281A JPS5481281A JP14834477A JP14834477A JPS5481281A JP S5481281 A JPS5481281 A JP S5481281A JP 14834477 A JP14834477 A JP 14834477A JP 14834477 A JP14834477 A JP 14834477A JP S5481281 A JPS5481281 A JP S5481281A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- fluorouracil
- group
- reacted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
NEW MATERIAL:An N1-(1-Alkoxy-4-hydroxybutyl)-5-fluorouracil of formula I: (R1' is alkyl group; R2 is vinyl or alkoxycarbonylmethyl group).
USE: An oncostatic drug and an intermediate for synthesis of N1-(2-tetrahydrofuryl)-5-fluorouracil, which is an anti-malignant solid cancer drug.
PROCESS: A 2,4-bistrimethylsilyl derivative of 5-fluorouracil (FU) is reacted with a compound of formula II in the presence of a Lewis acid, e.g. tin tetrachloride, etc. at -50W10°C to form a compound of formula III, which is hydroborated with a diborane when R2 is a vinyl group. The borane compound is then reacted with H2O2 to give the compound of formula I. When R2 is analkoxycarbonyl methyl group, a compound of formula III is reduced in the presence of an alkalimetal borohydride, e.g. potassium borohydride, etc. to form the compound of formula I.
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP52148344A JPS6019755B2 (en) | 1977-12-09 | 1977-12-09 | Production method of uracil derivatives |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP52148344A JPS6019755B2 (en) | 1977-12-09 | 1977-12-09 | Production method of uracil derivatives |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP59214785A Division JPS6048510B2 (en) | 1984-10-12 | 1984-10-12 | Production method of uracil derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5481281A true JPS5481281A (en) | 1979-06-28 |
JPS6019755B2 JPS6019755B2 (en) | 1985-05-17 |
Family
ID=15450657
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP52148344A Expired JPS6019755B2 (en) | 1977-12-09 | 1977-12-09 | Production method of uracil derivatives |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS6019755B2 (en) |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS49131217U (en) * | 1973-03-16 | 1974-11-12 | ||
JPS5097467A (en) * | 1973-12-28 | 1975-08-02 | ||
JPS5168708U (en) * | 1974-11-22 | 1976-05-31 |
-
1977
- 1977-12-09 JP JP52148344A patent/JPS6019755B2/en not_active Expired
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS49131217U (en) * | 1973-03-16 | 1974-11-12 | ||
JPS5097467A (en) * | 1973-12-28 | 1975-08-02 | ||
JPS5168708U (en) * | 1974-11-22 | 1976-05-31 |
Also Published As
Publication number | Publication date |
---|---|
JPS6019755B2 (en) | 1985-05-17 |
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