JPS5441882A - Production of uracil derivative - Google Patents
Production of uracil derivativeInfo
- Publication number
- JPS5441882A JPS5441882A JP10480077A JP10480077A JPS5441882A JP S5441882 A JPS5441882 A JP S5441882A JP 10480077 A JP10480077 A JP 10480077A JP 10480077 A JP10480077 A JP 10480077A JP S5441882 A JPS5441882 A JP S5441882A
- Authority
- JP
- Japan
- Prior art keywords
- uracil
- dimethyldichlorosilane
- production
- dihydrofuran
- tetrahydrofurfuryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Plural Heterocyclic Compounds (AREA)
Abstract
PURPOSE: The novel utilization of a small amount of dimethyldichlorosilane for the reaction between a uracil and 2,3-dihydrofuran gives an uracil derivative useful as carsinostatic agent or their intermediate in high yield.
CONSTITUTION: The reaction between uracil or 5-fluorouracil and 2,3-dihydrofuran is conducted in the presence of dimethyldichlorosilane and a tertiary amine to afford 1-(2-tetrahydrofurfuryl) uracil or 1-(2-tetrahydrofurfuryl)-5-fluorouracil. The dimethyldichlorosilane used is sufficient in an amount of about 0.2 to 1mol per mole of uracil.
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP52104800A JPS609036B2 (en) | 1977-09-02 | 1977-09-02 | Production method of uracil derivatives |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP52104800A JPS609036B2 (en) | 1977-09-02 | 1977-09-02 | Production method of uracil derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5441882A true JPS5441882A (en) | 1979-04-03 |
JPS609036B2 JPS609036B2 (en) | 1985-03-07 |
Family
ID=14390505
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP52104800A Expired JPS609036B2 (en) | 1977-09-02 | 1977-09-02 | Production method of uracil derivatives |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS609036B2 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4542493A (en) * | 1980-12-05 | 1985-09-17 | Victor Company Of Japan, Limited | Pickup stylus having fused diamond and ceramic bodies with conductive surfaces for capacitance disk records |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5278887A (en) * | 1975-12-25 | 1977-07-02 | Takeda Chem Ind Ltd | Synthesis of n-(2-tetrahydrofuryl)-5-fluorouracil |
-
1977
- 1977-09-02 JP JP52104800A patent/JPS609036B2/en not_active Expired
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5278887A (en) * | 1975-12-25 | 1977-07-02 | Takeda Chem Ind Ltd | Synthesis of n-(2-tetrahydrofuryl)-5-fluorouracil |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4542493A (en) * | 1980-12-05 | 1985-09-17 | Victor Company Of Japan, Limited | Pickup stylus having fused diamond and ceramic bodies with conductive surfaces for capacitance disk records |
Also Published As
Publication number | Publication date |
---|---|
JPS609036B2 (en) | 1985-03-07 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JPS5321178A (en) | Preparation of 1-(2-tetrahydrofuryl)uracils | |
JPS5441882A (en) | Production of uracil derivative | |
JPS53130679A (en) | Preparation of 1-carbamoyl-uracil | |
JPS51146482A (en) | Process for preparing n1-(2- tetrahydrofuryl)-5-fluorouracil | |
JPS52285A (en) | Preparation of n1 *22tetrahydrofuryl**55fluorouracil | |
JPS5289678A (en) | Preparation of 1-(2-tetrahydrofuryl)-5-fluorouracil | |
JPS53108988A (en) | Preparation of 1-(2-tetrahydrofuryl)-5-fluorouracil | |
JPS51113882A (en) | Method for preparing 1-(alpha -alkoxyalkyl)-uracil derivatives | |
JPS53149985A (en) | Preparation of 5-fluorouracil derivatives | |
JPS532478A (en) | Synthesis of 1-(2-tetrahydrofuryl)-5-fluorouracil | |
JPS5289679A (en) | Preparation of 5-fluorouracil derivatives | |
JPS52125177A (en) | Preparation of 1-(2-tetrahydrofuryl)-5-fluorouracil | |
JPS5432480A (en) | Novel preparation of piperidine derivatives | |
JPS53132530A (en) | Preparation of p-iodoaniline | |
JPS52118477A (en) | Synthesis of 1-(2-tetrahydrofuryl)-5-fluorouracil | |
JPS52118480A (en) | Synthesis of uracil derivatives | |
ES471365A1 (en) | A novel intermediate to prepare therapeutically active pyridine compounds and process for its preparation. | |
JPS53108983A (en) | Preparation of 5-fluorouracil | |
JPS5312875A (en) | Preparation of uracil derivatives | |
JPS5368791A (en) | Preparation of 1-(2'-tetrahydrofuryl)-5-fluorouracil | |
JPS5479290A (en) | Preparation of 5-fluorouracil derivative | |
JPS5236673A (en) | Preparation of pyrimidine derivative | |
JPS532479A (en) | Synthesis of n-substituted uracils | |
JPS53108987A (en) | Preparation of 1-(2'-tetrahydrofuryl)-5-fluorouracil | |
JPS52139079A (en) | Preparation of 1,3-bis(2-tetrahydrofuryl)-5-fluorouracil |