JPS5531011A - Alkali metal salt of cyclobranol succinic acid ester - Google Patents
Alkali metal salt of cyclobranol succinic acid esterInfo
- Publication number
- JPS5531011A JPS5531011A JP10278878A JP10278878A JPS5531011A JP S5531011 A JPS5531011 A JP S5531011A JP 10278878 A JP10278878 A JP 10278878A JP 10278878 A JP10278878 A JP 10278878A JP S5531011 A JPS5531011 A JP S5531011A
- Authority
- JP
- Japan
- Prior art keywords
- cyclobranol
- acid ester
- succinic acid
- alkali metal
- metal salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
NEW MATERIAL:Alkali metal salt of cyclobranol succinic acid ester of formula (M is Na or K).
EXAMPLE: Sodium cyclobranyl succinate.
USE: Hydrophilic medicine having little toxicity and few side effects, and higher effect than known cyclobranol or its ferulic acid ester having a pharmacological action to balance an autonomic nerve.
PROCESS: Cyclobranol derived from rice bran oil is reacted with excess succinic anhydride in an organic solvent at 90W100°C for 3W4hr, and formed cyclobranol succinic acid ester is separated from the unreacted components. The separated ester is dissolved in methanol containing a small amount of ethyl ether, and an equivalent amount of NaOH or KOH which is dissolved in methanol is added to the solution to form an alkali metal salt of the succinic acid ester, from which the desired compound is obtained by distillation off of methanol.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP53102788A JPS5811960B2 (en) | 1978-08-25 | 1978-08-25 | Cyclobranol succinic acid ester alkali metal salt |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP53102788A JPS5811960B2 (en) | 1978-08-25 | 1978-08-25 | Cyclobranol succinic acid ester alkali metal salt |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5531011A true JPS5531011A (en) | 1980-03-05 |
JPS5811960B2 JPS5811960B2 (en) | 1983-03-05 |
Family
ID=14336856
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP53102788A Expired JPS5811960B2 (en) | 1978-08-25 | 1978-08-25 | Cyclobranol succinic acid ester alkali metal salt |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5811960B2 (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4871727A (en) * | 1987-12-21 | 1989-10-03 | Merck & Co, Inc. | Anti-inflammatory and antidegenerative compounds isolated from L-681,512 |
US4874755A (en) * | 1987-12-21 | 1989-10-17 | Merck & Co., Inc. | Anti-inflammatory and antidegenrative compounds isolated from L-681,512 |
-
1978
- 1978-08-25 JP JP53102788A patent/JPS5811960B2/en not_active Expired
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4871727A (en) * | 1987-12-21 | 1989-10-03 | Merck & Co, Inc. | Anti-inflammatory and antidegenerative compounds isolated from L-681,512 |
US4874755A (en) * | 1987-12-21 | 1989-10-17 | Merck & Co., Inc. | Anti-inflammatory and antidegenrative compounds isolated from L-681,512 |
Also Published As
Publication number | Publication date |
---|---|
JPS5811960B2 (en) | 1983-03-05 |
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