GB847779A - 2-(4-biphenylyl)-í¸-hexenoic acid esters thereof - Google Patents

2-(4-biphenylyl)-í¸-hexenoic acid esters thereof

Info

Publication number
GB847779A
GB847779A GB12675/59A GB1267559A GB847779A GB 847779 A GB847779 A GB 847779A GB 12675/59 A GB12675/59 A GB 12675/59A GB 1267559 A GB1267559 A GB 1267559A GB 847779 A GB847779 A GB 847779A
Authority
GB
United Kingdom
Prior art keywords
biphenylyl
prepared
acetonitrile
hydrocarbon radical
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB12675/59A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Francesco Vismara SpA
Original Assignee
Francesco Vismara SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Francesco Vismara SpA filed Critical Francesco Vismara SpA
Publication of GB847779A publication Critical patent/GB847779A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C07C57/42—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings having unsaturation outside the rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The invention comprises compounds of the general formula: <FORM:0847779/IV(b)/1> in which R represents a hydrogen atom or a hydrocarbon radical containing up to 10 carbon atoms; and the preparation thereof, where R is hydrogen, by condensing 4-biphenylyl acetic acid nitrile or alkyl ester with crotyl bromide and hydrolysing the product in an alkaline medium or, where R is a hydrocarbon radical, by reacting the corresponding acid chloride, prepared by treating the acid with thionylchloride, with R-OH; and pharmaceutical compositions containing the products. The products are anticholesterinemic agents. 4-Biphenylyl acetonitrile is prepared by reacting 4-biphenylyl methylchloride with an alkali metal cyanide. 2-(4-Biphenylyl)-\se4-hexenoic acid nitrile is prepared by condensing 4-biphenylyl acetonitrile with crotyl bromide. Ethyl 4-biphenylyl-acetate is prepared by treating 4-biphenylyl acetonitrile with ethanol and sulphuric acid.ALSO:Pharmaceutical compositions comprise compounds of the general formula: p <FORM:0847779/VI/1> in which R represents a hydrogen atom or a hydrocarbon radical containing up to 10 carbon atoms, with a pharmaceutical diluent. Oral preparations may be in the form of tablets and capsules.
GB12675/59A 1958-04-14 1959-04-14 2-(4-biphenylyl)-í¸-hexenoic acid esters thereof Expired GB847779A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US847779XA 1958-04-14 1958-04-14

Publications (1)

Publication Number Publication Date
GB847779A true GB847779A (en) 1960-09-14

Family

ID=22187146

Family Applications (1)

Application Number Title Priority Date Filing Date
GB12675/59A Expired GB847779A (en) 1958-04-14 1959-04-14 2-(4-biphenylyl)-í¸-hexenoic acid esters thereof

Country Status (1)

Country Link
GB (1) GB847779A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4453005A (en) * 1982-12-06 1984-06-05 Merck Frosst Canada, Inc. Process for preparing substituted phenylalkenoic acids
DE3420387A1 (en) * 1983-06-03 1984-12-06 Scharper S.p.A. per l'Industria Farmaceutica, Mailand/Milano 2- (4-BIPHENYLYL) -4-HEXENONIC ACID AND ITS DERIVATIVES WITH ANTI-INFLAMMATORY EFFECTIVENESS
US4536515A (en) * 1982-12-06 1985-08-20 Merck Frosst Canada, Inc. Substituted phenylalkenoic acids and esters

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4453005A (en) * 1982-12-06 1984-06-05 Merck Frosst Canada, Inc. Process for preparing substituted phenylalkenoic acids
US4536515A (en) * 1982-12-06 1985-08-20 Merck Frosst Canada, Inc. Substituted phenylalkenoic acids and esters
DE3420387A1 (en) * 1983-06-03 1984-12-06 Scharper S.p.A. per l'Industria Farmaceutica, Mailand/Milano 2- (4-BIPHENYLYL) -4-HEXENONIC ACID AND ITS DERIVATIVES WITH ANTI-INFLAMMATORY EFFECTIVENESS
FR2547726A1 (en) * 1983-06-03 1984-12-28 Scharper Spa 2- (4-BIPHENYL) -4-HEXENOIC ACID AND DERIVATIVES HAVING ANTI-INFLAMMATORY ACTIVITY
GB2142015A (en) * 1983-06-03 1985-01-09 Scharper Spa 2-(4-biphenylyl)-4-hexenoic acids

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