GB1000803A - New uracil derivatives and process for their production - Google Patents

Abstract

The invention comprises compounds of general formula <FORM:1000803/C2/1> wherein R1 represents hydrogen or lower (1-6 C) alkyl, R2 represents hydrogen or lower alkyl, R3 represents lower alkyl or phenyl, and R1,R2 and R3 together contain at least 3 carbon atoms, and R4 represents hydrogen, halogen, hydroxyl or lower alkyl or alkoxy; the salts with bases of compounds having hydrogen as R1; and the preparation of these compounds and those in which R3 is hydrogen by (1) reacting a compound <FORM:1000803/C2/2> wherein R5 is lower alkyl with a compound R4-PhNCO (III) and treating the reaction product of formula <FORM:1000803/C2/3> with an alkaline condensing agent, (2) reacting a compound <FORM:1000803/C2/4> with a compound Y-COOR5 wherein 7 represents chlorine, bromine or lower alkoxy, and treating the reaction product of formula <FORM:1000803/C2/5> with an alkaline condensing agent, and (3) in either case then optionally reacting a compound having hydrogen as R1 with a reactive ester of a lower alkanol in the presence of an acid binding agent; a product having R4 hydroxy is obtained by process (1) starting with the corresponding acetoxy compound. b -Amino acid esters (II) may be prepared from a -alkanoyl acetic acid alkyl esters with ammonia or alkylamines. b -Amino acid anilides (VI) may be prepared from acetoacetanilides and ammonia or alkylamines. Pharmaceutical compositions comprise products of the invention together with carriers. Oral and parenteral administration is mentioned, the compounds having anti-inflammatory, analgesic and antipyretic activity and increasing sodium and chlorine excretion.