ES342460A1 - Process for the production of piperazine derivatives - Google Patents
Process for the production of piperazine derivativesInfo
- Publication number
- ES342460A1 ES342460A1 ES342460A ES342460A ES342460A1 ES 342460 A1 ES342460 A1 ES 342460A1 ES 342460 A ES342460 A ES 342460A ES 342460 A ES342460 A ES 342460A ES 342460 A1 ES342460 A1 ES 342460A1
- Authority
- ES
- Spain
- Prior art keywords
- general formula
- carbon atoms
- benzoic acid
- acid
- reacting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Novel piperazine derivatives of the general formula and salts thereof, wherein R stands for an alkyl radical having 1 or 2 carbon atoms, R 1 means hydrogen or an alkoxy radical having 1 or 2 carbon atoms, and A 1 and A 2 represent straight or branched chain alkylene radicals containing 1-4 carbon atoms, and A 2 may be substituted by a methoxy radical are obtained (a) by reacting a trialkoxy benzoic acid having the general formula or a functional derivative thereof, with an alcohol having the general formula if desired in the presence of an acid-binding agent, or (b) by condensing a trialkoxy benzoic acid haloalkyl ester having the formula wherein Hal represents a halogen atom, with a piperazine derivative having the general formula if desired in the presence of an acid-binding agent or (c) by reacting an alkali metal salt of a trialkoxy benzoic acid having the general formula with a piperazine derivative of the general formula Pharmaceutical compositions having coronary dilatory activity and containing the above compounds are administered orally or parenterally.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DEC0039517 | 1966-07-02 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES342460A1 true ES342460A1 (en) | 1968-09-16 |
Family
ID=7023770
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES342460A Expired ES342460A1 (en) | 1966-07-02 | 1967-06-30 | Process for the production of piperazine derivatives |
Country Status (10)
Country | Link |
---|---|
AT (2) | AT271481B (en) |
BE (1) | BE700811A (en) |
CH (1) | CH489509A (en) |
DE (1) | DE1670360A1 (en) |
DK (1) | DK120133B (en) |
ES (1) | ES342460A1 (en) |
FR (2) | FR1530040A (en) |
GB (1) | GB1127993A (en) |
IL (1) | IL28197A (en) |
NL (1) | NL6708818A (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2280634A2 (en) * | 1974-07-31 | 1976-02-27 | Synthelabo | 4-Phenyl-piperazino-alkyl anthranilate deriv prepn. - from 2-nitro-benzoic acid via acid halide or salts, condensation with phenyl-piperazino-alkyl radical and reduction |
JPS53112887A (en) * | 1977-03-12 | 1978-10-02 | Nippon Shinyaku Co Ltd | Production of n-substituted trialkoxybenzylpiperazine derivative |
JPS53112886A (en) * | 1977-03-12 | 1978-10-02 | Nippon Shinyaku Co Ltd | Production of n-substituted trialkoxybenzylpiperazine derivative |
HU173380B (en) * | 1977-02-25 | 1979-04-28 | Richter Gedeon Vegyeszet | Process for producing new pyridyl-piperazine derivatives and acid additional salts thereof |
ES2919779T3 (en) * | 2017-06-20 | 2022-07-28 | Imbria Pharmaceuticals Inc | 1-[(2,3,4-trimethoxyphenyl)methyl]-piperazine derivative, compositions thereof and methods for increasing the efficiency of cardiac metabolism |
-
1966
- 1966-07-02 DE DE19661670360 patent/DE1670360A1/en active Pending
-
1967
- 1967-06-23 NL NL6708818A patent/NL6708818A/xx unknown
- 1967-06-26 IL IL28197A patent/IL28197A/en unknown
- 1967-06-30 AT AT612067A patent/AT271481B/en active
- 1967-06-30 DK DK340467AA patent/DK120133B/en unknown
- 1967-06-30 CH CH929367A patent/CH489509A/en not_active IP Right Cessation
- 1967-06-30 ES ES342460A patent/ES342460A1/en not_active Expired
- 1967-06-30 FR FR112629A patent/FR1530040A/en not_active Expired
- 1967-06-30 BE BE700811D patent/BE700811A/xx unknown
- 1967-06-30 GB GB30330/67A patent/GB1127993A/en not_active Expired
- 1967-09-29 FR FR122786A patent/FR7173M/fr not_active Expired
-
1968
- 1968-07-01 AT AT625468A patent/AT272354B/en active
Also Published As
Publication number | Publication date |
---|---|
DK120133B (en) | 1971-04-13 |
AT272354B (en) | 1969-07-10 |
CH489509A (en) | 1970-04-30 |
BE700811A (en) | 1968-01-02 |
FR1530040A (en) | 1968-06-21 |
NL6708818A (en) | 1968-01-03 |
AT271481B (en) | 1969-06-10 |
FR7173M (en) | 1969-08-11 |
IL28197A (en) | 1971-05-26 |
DE1670360A1 (en) | 1970-10-29 |
GB1127993A (en) | 1968-09-25 |
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