GB1107036A - Esters of dibenzocycloheptenyl-carboxylic acids - Google Patents

Esters of dibenzocycloheptenyl-carboxylic acids

Info

Publication number
GB1107036A
GB1107036A GB44518/64A GB4451864A GB1107036A GB 1107036 A GB1107036 A GB 1107036A GB 44518/64 A GB44518/64 A GB 44518/64A GB 4451864 A GB4451864 A GB 4451864A GB 1107036 A GB1107036 A GB 1107036A
Authority
GB
United Kingdom
Prior art keywords
formula
reacting
acid
alcohol
alkali metal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB44518/64A
Inventor
Cornelis Van Der Stelt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Koninklijke Pharmaceutische Fabrieken NV
Original Assignee
Koninklijke Pharmaceutische Fabrieken NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Koninklijke Pharmaceutische Fabrieken NV filed Critical Koninklijke Pharmaceutische Fabrieken NV
Priority to GB44518/64A priority Critical patent/GB1107036A/en
Priority to US484420A priority patent/US3349093A/en
Priority to IL24463A priority patent/IL24463A/en
Priority to NO160123A priority patent/NO119477B/no
Priority to NL6513732A priority patent/NL6513732A/xx
Priority to DE19651620077 priority patent/DE1620077A1/en
Priority to BE671433A priority patent/BE671433A/xx
Priority to FI2565/65A priority patent/FI42835B/fi
Priority to BR174404/65A priority patent/BR6574404D0/en
Priority to FR1553663D priority patent/FR1553663A/fr
Priority to SE13988/65A priority patent/SE326952B/xx
Priority to DK559165AA priority patent/DK116213B/en
Priority to FR47560A priority patent/FR6669M/fr
Publication of GB1107036A publication Critical patent/GB1107036A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C62/30—Unsaturated compounds
    • C07C62/32—Unsaturated compounds containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine

Abstract

<FORM:1107036/C2/1> <FORM:1107036/C2/2> <FORM:1107036/C2/3> Novel esters of the Formula I, wherein X represents an ethylene or ethenylene radical, R1 and R2, the same or different, represent a hydrogen or halogen atom or C1- 5 alkyl group, and R3 represents a saturated polycyclic nitrogen-containin heterocyclic radical with at most 12 carbon atoms attached through carbon to the oxygen atom, and acid addition salts thereof, are prepared by reacting the corresponding free acid of the Formula II, or a reactive derivative thereof, with an alcohol of the formula R3OH, by reacting said acid or an alkali metal salt thereof with a halide of the formula R3Y (wherein Y represents a halogen atom), or by esterifying said acid with a C1- 5 alkanol and transesterifying the resultant ester with an alcohol of the formula R3OH. Carboxylic acids of the Formula II may be prepared by reacting a ketone of the Formula III with an alkali metal followed by carbon dioxide. Therapeutic compositions with anti-arrhythmic and atropine-like properties, which may take forms suitable for oral and parenteral administration, comprise compounds of the Formula I or their non-toxic acid addition salts, together with a suitable carrier.
GB44518/64A 1964-10-31 1964-10-31 Esters of dibenzocycloheptenyl-carboxylic acids Expired GB1107036A (en)

Priority Applications (13)

Application Number Priority Date Filing Date Title
GB44518/64A GB1107036A (en) 1964-10-31 1964-10-31 Esters of dibenzocycloheptenyl-carboxylic acids
US484420A US3349093A (en) 1964-10-31 1965-09-01 5-hydroxy-dibenzocyclohepten-5-yl-carboxylates
IL24463A IL24463A (en) 1964-10-31 1965-10-14 Tropanyl and quinuclidinyl esters of dibenzocycloheptene and 10,11-dihydro-dibenzocycloheptene carboxylic acids and their preparation
NO160123A NO119477B (en) 1964-10-31 1965-10-18
NL6513732A NL6513732A (en) 1964-10-31 1965-10-22
DE19651620077 DE1620077A1 (en) 1964-10-31 1965-10-26 Dibenzecycloheptenyl ester and process for their preparation
BE671433A BE671433A (en) 1964-10-31 1965-10-26
FI2565/65A FI42835B (en) 1964-10-31 1965-10-27
BR174404/65A BR6574404D0 (en) 1964-10-31 1965-10-29 DI-BENZO-CYCLE-HEPTENYL ESTERS
FR1553663D FR1553663A (en) 1964-10-31 1965-10-29
SE13988/65A SE326952B (en) 1964-10-31 1965-10-29
DK559165AA DK116213B (en) 1964-10-31 1965-10-30 Process for the preparation of dibenzocycloheptenyl esters or acid addition salts thereof.
FR47560A FR6669M (en) 1964-10-31 1966-01-28

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB44518/64A GB1107036A (en) 1964-10-31 1964-10-31 Esters of dibenzocycloheptenyl-carboxylic acids

Publications (1)

Publication Number Publication Date
GB1107036A true GB1107036A (en) 1968-03-20

Family

ID=10433672

Family Applications (1)

Application Number Title Priority Date Filing Date
GB44518/64A Expired GB1107036A (en) 1964-10-31 1964-10-31 Esters of dibenzocycloheptenyl-carboxylic acids

Country Status (12)

Country Link
US (1) US3349093A (en)
BE (1) BE671433A (en)
BR (1) BR6574404D0 (en)
DE (1) DE1620077A1 (en)
DK (1) DK116213B (en)
FI (1) FI42835B (en)
FR (2) FR1553663A (en)
GB (1) GB1107036A (en)
IL (1) IL24463A (en)
NL (1) NL6513732A (en)
NO (1) NO119477B (en)
SE (1) SE326952B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4038299A (en) * 1975-05-30 1977-07-26 Syntex (U.S.A.) Inc. 2-Substituted-5-oxo-5H-dibenzo [a,d] -cycloheptene esters
DE4108393A1 (en) * 1991-03-15 1992-09-17 Boehringer Ingelheim Kg NEW ESTERS BI-AND TRICYCLIC AMINO ALCOHOLS, THEIR PREPARATION AND THEIR USE IN MEDICINAL PRODUCTS

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB969024A (en) * 1961-04-27 1964-09-09 Koninklijke Pharma Fab Nv Dihydrodibenzocycloheptene carboxylic acid esters

Also Published As

Publication number Publication date
DK116213B (en) 1969-12-22
US3349093A (en) 1967-10-24
BR6574404D0 (en) 1973-08-16
FR6669M (en) 1969-02-03
DE1620077A1 (en) 1970-02-12
FR1553663A (en) 1969-01-17
FI42835B (en) 1970-08-03
IL24463A (en) 1969-06-25
BE671433A (en) 1966-04-26
NL6513732A (en) 1966-05-02
NO119477B (en) 1970-05-25
SE326952B (en) 1970-08-10

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