ES417883A1 - Substituted 4-biphenylyl-butenoic acids esters and amides and pharmaceutical compositions containing them - Google Patents

Substituted 4-biphenylyl-butenoic acids esters and amides and pharmaceutical compositions containing them

Info

Publication number
ES417883A1
ES417883A1 ES417883A ES417883A ES417883A1 ES 417883 A1 ES417883 A1 ES 417883A1 ES 417883 A ES417883 A ES 417883A ES 417883 A ES417883 A ES 417883A ES 417883 A1 ES417883 A1 ES 417883A1
Authority
ES
Spain
Prior art keywords
formula
general formula
group
compounds
radical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES417883A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH
Publication of ES417883A1 publication Critical patent/ES417883A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C245/00—Compounds containing chains of at least two nitrogen atoms with at least one nitrogen-to-nitrogen multiple bond
    • C07C245/12—Diazo compounds, i.e. compounds having the free valencies of >N2 groups attached to the same carbon atom
    • C07C245/14—Diazo compounds, i.e. compounds having the free valencies of >N2 groups attached to the same carbon atom having diazo groups bound to acyclic carbon atoms of a carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
    • C07C17/16—Preparation of halogenated hydrocarbons by replacement by halogens of hydroxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
    • C07C17/20—Preparation of halogenated hydrocarbons by replacement by halogens of halogen atoms by other halogen atoms
    • C07C17/202—Preparation of halogenated hydrocarbons by replacement by halogens of halogen atoms by other halogen atoms two or more compounds being involved in the reaction
    • C07C17/208—Preparation of halogenated hydrocarbons by replacement by halogens of halogen atoms by other halogen atoms two or more compounds being involved in the reaction the other compound being MX
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
    • C07C45/57—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom
    • C07C45/58—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom in three-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
    • C07C49/813—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
    • C07C57/60—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings having unsaturation outside the rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/64—Acyl halides
    • C07C57/76—Acyl halides containing halogen outside the carbonyl halide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/56—Unsaturated compounds containing hydroxy or O-metal groups containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/48—Compounds containing oxirane rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32—Oxygen atoms
    • C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/54—Quaternary phosphonium compounds
    • C07F9/5407—Acyclic saturated phosphonium compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins

Abstract

Procedure for the preparation of biphenyl derivatives of the general formula I ** (See formula) ** where R1 represents a fluorine atom in the 2'or 4' position and B represents the hydroxy group, an alkoxy group or a group of the formula (see formula), in which R2 and R3, which may be the same or different from each other, signify hydrogen atoms, the carboxymethyl radical, a lower alcohol radical, a phenyl radical optionally substituted by a hydroxy or methyl group, as well as its salts with organic or inorganic bases, if B means the hydroxy group, characterized in that for the preparation of compounds of the general formula I, in which B means an alkoxy radical, a ketone of the formula II is reacted ** (See formula) ** wherein R1 is as defined above, with the zinc compound of a halogenoacetic acid ester in an organic solvent at 15 to 120ºC, and the compounds of general formula I in which B signifies the alkoxy group, obtained therefrom Thus, if desired, they are transformed by saponification into the acids of the general formula I and/or the compounds of the general formula I in which B represents the hydroxy group, if desired are transformed into their salts with organic or inorganic bases, or if desired the compounds of the general formula I, in which B represents an alkoxy group or a halogen atom, obtained according to the procedure indicated above, are reacted if desired with an amine of the formula HNR3R2 to form a compound of the general formula I, in which B means the group (see formula) (Machine-translation by Google Translate, not legally binding)
ES417883A 1972-08-17 1973-08-14 Substituted 4-biphenylyl-butenoic acids esters and amides and pharmaceutical compositions containing them Expired ES417883A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2240441A DE2240441A1 (en) 1972-08-17 1972-08-17 NEW BIPHENYL DERIVATIVES AND METHOD OF MANUFACTURING

Publications (1)

Publication Number Publication Date
ES417883A1 true ES417883A1 (en) 1976-11-16

Family

ID=5853790

Family Applications (4)

Application Number Title Priority Date Filing Date
ES417884A Expired ES417884A1 (en) 1972-08-17 1973-08-14 Substituted 4-biphenylyl-butenoic acids esters and amides and pharmaceutical compositions containing them
ES417883A Expired ES417883A1 (en) 1972-08-17 1973-08-14 Substituted 4-biphenylyl-butenoic acids esters and amides and pharmaceutical compositions containing them
ES432464A Expired ES432464A1 (en) 1972-08-17 1974-11-30 Substituted 4-biphenylyl-butenoic acids esters and amides and pharmaceutical compositions containing them
ES432465A Expired ES432465A1 (en) 1972-08-17 1974-11-30 Substituted 4-biphenylyl-butenoic acids esters and amides and pharmaceutical compositions containing them

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES417884A Expired ES417884A1 (en) 1972-08-17 1973-08-14 Substituted 4-biphenylyl-butenoic acids esters and amides and pharmaceutical compositions containing them

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES432464A Expired ES432464A1 (en) 1972-08-17 1974-11-30 Substituted 4-biphenylyl-butenoic acids esters and amides and pharmaceutical compositions containing them
ES432465A Expired ES432465A1 (en) 1972-08-17 1974-11-30 Substituted 4-biphenylyl-butenoic acids esters and amides and pharmaceutical compositions containing them

Country Status (19)

Country Link
JP (2) JPS49124052A (en)
AT (3) AT328427B (en)
AU (2) AU5930873A (en)
BE (3) BE803734A (en)
BG (3) BG21197A3 (en)
CH (1) CH588435A5 (en)
CS (3) CS165386B2 (en)
DD (2) DD108071A5 (en)
DE (1) DE2240441A1 (en)
ES (4) ES417884A1 (en)
FR (2) FR2196168B1 (en)
GB (2) GB1410852A (en)
HU (2) HU166517B (en)
IL (2) IL43004A0 (en)
NL (2) NL7311301A (en)
PL (2) PL94510B1 (en)
RO (2) RO62917A (en)
SU (11) SU482039A3 (en)
ZA (3) ZA735628B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2457275A1 (en) * 1979-05-21 1980-12-19 Fabre Sa Pierre P-BIPHENYL-4 METHYL-2 BUTEN-3 OIC ACIDS USEFUL IN THE TREATMENT OF RHUMATISMS
RU2686489C1 (en) * 2018-12-27 2019-04-29 Федеральное государственное бюджетное образовательное учреждение высшего образования "Санкт-Петербургский государственный университет (СПбГУ)" Method of producing α-diazocarbonyl compounds in aqueous medium

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2162038A1 (en) * 1970-05-05 1972-08-17 William H Rorer Ine , Fort Washington, Pa (V St A ) Process for the production of synthetic alkanoic acids and their derivatives
BE776316R (en) * 1971-03-10 1972-06-06 Rorer Inc William H Phenylacetic acid derivs - as antiinflammatory agents

Also Published As

Publication number Publication date
RO62918A (en) 1978-04-15
JPS49124052A (en) 1974-11-27
FR2196168A1 (en) 1974-03-15
ES417884A1 (en) 1976-03-16
ES432464A1 (en) 1977-02-16
AT323143B (en) 1975-06-25
SU520907A3 (en) 1976-07-05
NL7311301A (en) 1974-02-19
AU5930973A (en) 1975-02-20
FR2196168B1 (en) 1977-02-25
BE803734A (en) 1974-02-18
SU520030A3 (en) 1976-06-30
CS165386B2 (en) 1975-12-22
JPS49124051A (en) 1974-11-27
GB1411495A (en) 1975-10-29
BE803732A (en) 1974-02-18
CH588435A5 (en) 1977-05-31
SU554810A3 (en) 1977-04-15
RO62917A (en) 1978-02-15
IL43003A0 (en) 1973-11-28
CS165387B2 (en) 1975-12-22
ZA735629B (en) 1976-01-28
SU561505A3 (en) 1977-06-05
BE803733A (en) 1974-02-18
BG22069A3 (en) 1976-11-25
SU484679A3 (en) 1975-09-15
FR2196167A1 (en) 1974-03-15
BG21197A3 (en) 1976-03-20
PL90397B1 (en) 1977-01-31
PL94510B1 (en) 1977-08-31
AU5930873A (en) 1975-02-20
SU482039A3 (en) 1975-08-25
ZA735628B (en) 1975-04-30
BG21844A3 (en) 1976-09-20
SU511846A3 (en) 1976-04-25
SU552021A3 (en) 1977-03-25
DD107901A5 (en) 1974-08-20
SU577967A3 (en) 1977-10-25
FR2196167B1 (en) 1977-04-15
AT328427B (en) 1976-03-25
AU476340B2 (en) 1976-09-16
GB1410852A (en) 1975-10-22
IL43004A0 (en) 1973-11-28
CS165385B2 (en) 1975-12-22
AT323144B (en) 1975-06-25
HU166516B (en) 1975-03-28
ZA735616B (en) 1976-01-28
ES432465A1 (en) 1976-11-16
NL7311300A (en) 1974-02-19
SU538658A3 (en) 1976-12-05
ATA711273A (en) 1975-06-15
HU166517B (en) 1975-03-28
SU511847A3 (en) 1976-04-25
DD108071A5 (en) 1974-09-05
DE2240441A1 (en) 1974-02-28

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