ES364722A1 - Procedure for the preparation of new derivatives of paminoalquil-bencensulfonamida. (Machine-translation by Google Translate, not legally binding) - Google Patents

Abstract

Procedure for the preparation of new derivatives of p-aminoalkyl-benzenesulfonamide of the general formula I **(See formula)** in which m means 2 or 3, R1 means an alkyl group with 12 carbon atoms at most, an alkenyl group with 3-5 carbon atoms, a cycloalkyl or cycloalkenyl group with 7 carbon atoms at most, or a phenylalkyl group with 9 carbon atoms at most, R2 means hydrogen or an alkyl group with 2 carbon atoms at most, R3 means hydrogen, an alkyl or chloroalkyl group with at most 7 carbon atoms, an alkenyl group with at most 5 carbon atoms, a cycloalkyl or cycloalkenyl group with at most 8 carbon atoms, a phenyl group or a group phenylalkyl or phenylalkyl with 10 carbon atoms at most, where the phenyl group present as R3 or R3 may be substituted one to three times by halogen up to atomic number 35, trifluoromethyl groups, alkyl groups with 4 carbon atoms at most, hydroxylic, alkoxy or C2 -alkylthio groups at most, and R4 means hydrogen or the methyl group, and its addition salts with inorganic or organic acids, characterized in that an acid of the general formula II., R3-COOH (II) in which R3 has the significance indicated under formula I, or a functional derivative suitable for reaction of one of such acids, is reacted with a compound of the general formula III, **(See formula)** in which m, R1, R2 and R4 have the significance indicated under formula I, and the reaction product is optionally transformed with an inorganic or organic acid into an addition salt. (Machine-translation by Google Translate, not legally binding)