ES385701A1 - Benzofuran and benzothiophene carboxylic acids processes for their production and medicaments containing same - Google Patents

Benzofuran and benzothiophene carboxylic acids processes for their production and medicaments containing same

Info

Publication number
ES385701A1
ES385701A1 ES385701A ES385701A ES385701A1 ES 385701 A1 ES385701 A1 ES 385701A1 ES 385701 A ES385701 A ES 385701A ES 385701 A ES385701 A ES 385701A ES 385701 A1 ES385701 A1 ES 385701A1
Authority
ES
Spain
Prior art keywords
formula
stands
carboxylic acids
general formula
benzofuran
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES385701A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
JR Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by JR Geigy AG filed Critical JR Geigy AG
Publication of ES385701A1 publication Critical patent/ES385701A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/56—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D307/85—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D333/70—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Procedure for the preparation of new heterocyclic carboxylic acids of the general formula I **(See formula)** in which X stands for oxygen or sulfur, X stands for hydrogen or the methyl group, Z1 stands for halogen up to atomic number 17, the methyl or methoxy group, Z2 means hydrogen or the methyl group and R means an alkyl group with 1-5 carbon atoms, as well as its salts with inorganic or organic bases, characterized in that a compound of the general formula II is reacted, **(See formula)** in which X, Y, Z1 and Z2 have the significance indicated under formula I, or a functional derivative suitable for reaction of one of such compounds, with a 1-nitro-alkane of the general formula III, **(See formula)** in which R has the significance indicated under formula I, and a carboxylic acid obtained is optionally transformed with an inorganic or organic base into a salt. (Machine-translation by Google Translate, not legally binding)
ES385701A 1969-11-20 1970-11-19 Benzofuran and benzothiophene carboxylic acids processes for their production and medicaments containing same Expired ES385701A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH1727369A CH523236A (en) 1969-11-20 1969-11-20 Process for the preparation of new heterocyclic carboxylic acids

Publications (1)

Publication Number Publication Date
ES385701A1 true ES385701A1 (en) 1973-10-01

Family

ID=4424112

Family Applications (2)

Application Number Title Priority Date Filing Date
ES385702A Expired ES385702A1 (en) 1969-11-20 1970-11-19 Benzofuran and benzothiophene carboxylic acids processes for their production and medicaments containing same
ES385701A Expired ES385701A1 (en) 1969-11-20 1970-11-19 Benzofuran and benzothiophene carboxylic acids processes for their production and medicaments containing same

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES385702A Expired ES385702A1 (en) 1969-11-20 1970-11-19 Benzofuran and benzothiophene carboxylic acids processes for their production and medicaments containing same

Country Status (15)

Country Link
AT (2) AT299937B (en)
BE (1) BE759138A (en)
BG (1) BG18182A3 (en)
CA (1) CA963016A (en)
CH (2) CH523236A (en)
DE (1) DE2056935A1 (en)
DK (1) DK126038B (en)
ES (2) ES385702A1 (en)
FR (1) FR2073396B1 (en)
GB (1) GB1312470A (en)
IL (1) IL35693A (en)
NL (1) NL7016683A (en)
SE (1) SE375531B (en)
SU (1) SU366609A3 (en)
ZA (1) ZA707819B (en)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH510008A (en) * 1968-05-30 1971-07-15 Ciba Geigy Ag Benzofuranyl-and benzothienyl-carboxylic acids

Also Published As

Publication number Publication date
SU366609A3 (en) 1973-01-16
ES385702A1 (en) 1973-04-01
FR2073396A1 (en) 1971-10-01
CH523237A (en) 1972-05-31
FR2073396B1 (en) 1974-02-22
AT299937B (en) 1972-07-10
CA963016A (en) 1975-02-18
AT305275B (en) 1973-02-26
GB1312470A (en) 1973-04-04
ZA707819B (en) 1971-08-25
NL7016683A (en) 1971-05-24
IL35693A (en) 1973-06-29
BG18182A3 (en) 1974-09-02
DK126038B (en) 1973-06-04
SE375531B (en) 1975-04-21
CH523236A (en) 1972-05-31
DE2056935A1 (en) 1971-05-27
IL35693A0 (en) 1971-01-28
BE759138A (en) 1971-05-19

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