ES364724A1 - Procedure for the preparation of new derivatives of paminoalquil-bencensulfonamida. (Machine-translation by Google Translate, not legally binding) - Google Patents

Abstract

Process for the preparation of new p-aminoalkylbenzenesulfonamide derivatives of the general formula i ** (see formula) ** In which M is 2 or 3, R1 means an alkyl group with at most 12 carbon atoms, an alkenyl group with 3-5 carbon atoms, a cycloalkyl or cycloalkenyl group with at most 7 carbon atoms or a phenylalkyl group with 9 carbon atoms at most, R2 means hydrogen or an alkyl group with 2 carbon atoms at most, R3 means hydrogen, an alkyl or chloroalkyl group with at most 7 carbon atoms, an alkenyl group with not more than 5 carbon atoms, a cycloalkyl or cycloalkenyl group with not more than 8 carbon atoms, a phenyl group or a group phenylalkyl or phenylalkenyl with at most 10 carbon atoms, wherein the phenyl group present as or in r 3 can be substituted one to three times by halogen up to the atomic number 35, trifluormethyl groups, alkyl groups with 4 carbon atoms at the most, hydroxyl groups, alkoxy or alkylthio with 2 carbon atoms at most, and R4 means hydrogen or the methyl group, and their addition salts with inorganic or organic acids, characterized in that a compound of the general formula ii, ** (see formula) ** In which M, r3 and r4 have the significance indicated under formula i, The ring is condensed with an ester suitable for reaction of a hydroxy compound of the general formula iii ** (see formula) ** In which R1 and r2 have the significance indicated under formula i, And the compound obtained is optionally converted with an inorganic or organic acid into an addition salt. (Machine-translation by Google Translate, not legally binding)