ES364723A1 - Procedure for the preparation of new derivatives of paminoalquil-bencensulfonamida. (Machine-translation by Google Translate, not legally binding) - Google Patents

Abstract

Procedure for the preparation of new derivatives of p-aminoalkyl-benzenesulfonamide of the general formula I **(See formula)** in which m means 2 or 3, R1 means an alkyl group with 12 carbon atoms at most, an alkenyl group with 3-5 carbon atoms, a cycloalkyl or cycloalkenyl group with 7 carbon atoms at most, or a phenylalkyl group with 9 carbon atoms at most, R2 means hydrogen or an alkyl group with 2 carbon atoms at most, R3 means hydrogen, an alkyl or chloro-alkyl group with at most 7 carbon atoms, an alkenyl group with at most 5 carbon atoms, a cycloalkyl or cycloalkenyl group with at most 8 carbon atoms, a phenyl group or a phenylalkyl or phenylalkyl group with 10 carbon atoms at most, where the phenyl group present as R3 or R3, may be substituted one to three times by halogen up to atomic number 35, trifluoromethyl groups, alkyl groups with 4 carbon atoms at most, hydroxy groups, alkoxy or alkylthio with 2 carbon atoms at most, and R4 means hydrogen or the methyl group, and its addition salts with inorganic or organic acids, characterized in that a compound of the general formula II, in which m, R1, R2, R3 and R4 have the significance indicated under formula I and R5 means hydrogen, an arylmethyl, diarylmethyl or triarylmethyl group, the methyl or allyl group, it is condensed with a cyanic acid derivative suitable for reaction under ring closure, optionally under cleavage of an R5-halide and the obtained compound is optionally transformed with an inorganic or organic acid with an addition salt. (Machine-translation by Google Translate, not legally binding)