ES440029A1 - 2-aminoindane derivatives - Google Patents

2-aminoindane derivatives

Info

Publication number
ES440029A1
ES440029A1 ES440029A ES440029A ES440029A1 ES 440029 A1 ES440029 A1 ES 440029A1 ES 440029 A ES440029 A ES 440029A ES 440029 A ES440029 A ES 440029A ES 440029 A1 ES440029 A1 ES 440029A1
Authority
ES
Spain
Prior art keywords
formula
radical
aminoindane
derivatives
carbon atoms
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES440029A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
A Christiaens SA
Original Assignee
A Christiaens SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by A Christiaens SA filed Critical A Christiaens SA
Publication of ES440029A1 publication Critical patent/ES440029A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

A procedure to prepare new 2-aminoindane derivatives of the general formula: **(See formula)** in which n is equal to 2, 3 or 4, with the group (CH2) n having a straight chain in which one or more hydrogen atoms may be replaced by a hydroxyl radical, R1 represents a lower alcohol or lower hydroxyalkyl radical that contains 1 to 4 carbon atoms or a lower alkenyl or lower alkynyl radical containing 2 or 3 carbon atoms, A is an unsubstituted phenyl radical or a substituted phenyl radical with at least one substituent at the ortho, meta and/positions or for as well as the acid addition salts of said derivatives of formula I, comprising, dealkylating an N-phenyl- [or N- (2-pyridyl)] - 2- [N- (1-dialkylaminoalkyl)] -aminoindane of the formula: **(See formula)** in which n, A and R1 have the same defined meanings and R2 has the same defined meaning for R1, by means of cyanogen bromide, the compound of formula I obtained being transformed, if necessary, into an acid addition salt. (Machine-translation by Google Translate, not legally binding)
ES440029A 1972-09-18 1975-08-05 2-aminoindane derivatives Expired ES440029A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB4315072 1972-09-18
GB998773*[A GB1405444A (en) 1972-09-18 1973-03-01 2-aminoindane derivatives
GB998873 1973-03-01
GB1030373 1973-03-02

Publications (1)

Publication Number Publication Date
ES440029A1 true ES440029A1 (en) 1977-02-16

Family

ID=27447738

Family Applications (3)

Application Number Title Priority Date Filing Date
ES418827A Expired ES418827A1 (en) 1972-09-18 1973-09-17 2-aminoindane derivatives
ES440029A Expired ES440029A1 (en) 1972-09-18 1975-08-05 2-aminoindane derivatives
ES440030A Expired ES440030A1 (en) 1972-09-18 1975-08-05 2-aminoindane derivatives

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES418827A Expired ES418827A1 (en) 1972-09-18 1973-09-17 2-aminoindane derivatives

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES440030A Expired ES440030A1 (en) 1972-09-18 1975-08-05 2-aminoindane derivatives

Country Status (13)

Country Link
JP (1) JPS5327263B2 (en)
AR (4) AR206505A1 (en)
CA (1) CA992547A (en)
CH (1) CH585690A5 (en)
DD (2) DD108277A5 (en)
ES (3) ES418827A1 (en)
FR (1) FR2199988B1 (en)
GB (1) GB1405444A (en)
HU (1) HU168018B (en)
IL (1) IL43218A (en)
LU (1) LU68426A1 (en)
MX (1) MX3233E (en)
NL (1) NL152246B (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4975461A (en) * 1986-06-19 1990-12-04 E. R. Squibb & Sons, Inc. P-aminophenols, derivatives thereof and method of use
JPH0293610U (en) * 1989-01-09 1990-07-25
EP1658847A3 (en) * 1999-06-10 2006-07-26 Bridge Pharma, Inc. Indane derivatives as dermal anesthetic agents
CA2376819C (en) * 1999-06-10 2008-09-02 Bridge Pharma, Inc. 2-aminoindane derivatives as dermal anesthetic agents
JP4660045B2 (en) 1999-09-17 2011-03-30 松森　　昭 Prophylactic or therapeutic agent for myocarditis, dilated cardiomyopathy and heart failure comprising NF-κB inhibitor as an active ingredient
US20010018446A1 (en) 1999-09-23 2001-08-30 G.D. Searle & Co. Substituted N-Aliphatic-N-Aromatictertiary-Heteroalkylamines useful for inhibiting cholesteryl ester transfer protein activity
US7718674B2 (en) 2004-09-27 2010-05-18 Bridge Pharma, Inc. Methods of relieving neuropathic pain with the S-isomer of 2-{2[N-(2-indanyl)-N-phenylamino]ethyl}piperidine
US7592458B2 (en) 2006-07-21 2009-09-22 Wright George E Dermal anesthetic compounds and pharmaceutical compositions for inducing local anesthesia and mitigating neuropathic pain

Also Published As

Publication number Publication date
JPS4969648A (en) 1974-07-05
DE2346337B2 (en) 1976-08-26
IL43218A (en) 1977-05-31
ES418827A1 (en) 1977-02-01
FR2199988B1 (en) 1977-11-25
AR205891A1 (en) 1976-06-15
AR204247A1 (en) 1975-12-10
NL7312776A (en) 1974-03-20
ES440030A1 (en) 1977-02-16
GB1405444A (en) 1975-09-10
DE2346337A1 (en) 1974-04-04
JPS5327263B2 (en) 1978-08-07
DD108277A5 (en) 1974-09-12
AR206505A1 (en) 1976-07-30
IL43218A0 (en) 1973-11-28
CH585690A5 (en) 1977-03-15
DD109802A5 (en) 1974-11-20
CA992547A (en) 1976-07-06
AU6028373A (en) 1975-03-13
AR203500A1 (en) 1975-09-15
FR2199988A1 (en) 1974-04-19
MX3233E (en) 1980-08-05
NL152246B (en) 1977-02-15
LU68426A1 (en) 1973-11-26
HU168018B (en) 1976-02-28

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