ES440029A1 - 2-aminoindane derivatives - Google Patents
2-aminoindane derivativesInfo
- Publication number
- ES440029A1 ES440029A1 ES440029A ES440029A ES440029A1 ES 440029 A1 ES440029 A1 ES 440029A1 ES 440029 A ES440029 A ES 440029A ES 440029 A ES440029 A ES 440029A ES 440029 A1 ES440029 A1 ES 440029A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- radical
- aminoindane
- derivatives
- carbon atoms
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
A procedure to prepare new 2-aminoindane derivatives of the general formula: **(See formula)** in which n is equal to 2, 3 or 4, with the group (CH2) n having a straight chain in which one or more hydrogen atoms may be replaced by a hydroxyl radical, R1 represents a lower alcohol or lower hydroxyalkyl radical that contains 1 to 4 carbon atoms or a lower alkenyl or lower alkynyl radical containing 2 or 3 carbon atoms, A is an unsubstituted phenyl radical or a substituted phenyl radical with at least one substituent at the ortho, meta and/positions or for as well as the acid addition salts of said derivatives of formula I, comprising, dealkylating an N-phenyl- [or N- (2-pyridyl)] - 2- [N- (1-dialkylaminoalkyl)] -aminoindane of the formula: **(See formula)** in which n, A and R1 have the same defined meanings and R2 has the same defined meaning for R1, by means of cyanogen bromide, the compound of formula I obtained being transformed, if necessary, into an acid addition salt. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB4315072 | 1972-09-18 | ||
GB998773*[A GB1405444A (en) | 1972-09-18 | 1973-03-01 | 2-aminoindane derivatives |
GB998873 | 1973-03-01 | ||
GB1030373 | 1973-03-02 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES440029A1 true ES440029A1 (en) | 1977-02-16 |
Family
ID=27447738
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES418827A Expired ES418827A1 (en) | 1972-09-18 | 1973-09-17 | 2-aminoindane derivatives |
ES440029A Expired ES440029A1 (en) | 1972-09-18 | 1975-08-05 | 2-aminoindane derivatives |
ES440030A Expired ES440030A1 (en) | 1972-09-18 | 1975-08-05 | 2-aminoindane derivatives |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES418827A Expired ES418827A1 (en) | 1972-09-18 | 1973-09-17 | 2-aminoindane derivatives |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES440030A Expired ES440030A1 (en) | 1972-09-18 | 1975-08-05 | 2-aminoindane derivatives |
Country Status (13)
Country | Link |
---|---|
JP (1) | JPS5327263B2 (en) |
AR (4) | AR206505A1 (en) |
CA (1) | CA992547A (en) |
CH (1) | CH585690A5 (en) |
DD (2) | DD108277A5 (en) |
ES (3) | ES418827A1 (en) |
FR (1) | FR2199988B1 (en) |
GB (1) | GB1405444A (en) |
HU (1) | HU168018B (en) |
IL (1) | IL43218A (en) |
LU (1) | LU68426A1 (en) |
MX (1) | MX3233E (en) |
NL (1) | NL152246B (en) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4975461A (en) * | 1986-06-19 | 1990-12-04 | E. R. Squibb & Sons, Inc. | P-aminophenols, derivatives thereof and method of use |
JPH0293610U (en) * | 1989-01-09 | 1990-07-25 | ||
EP1658847A3 (en) * | 1999-06-10 | 2006-07-26 | Bridge Pharma, Inc. | Indane derivatives as dermal anesthetic agents |
CA2376819C (en) * | 1999-06-10 | 2008-09-02 | Bridge Pharma, Inc. | 2-aminoindane derivatives as dermal anesthetic agents |
JP4660045B2 (en) | 1999-09-17 | 2011-03-30 | 松森 昭 | Prophylactic or therapeutic agent for myocarditis, dilated cardiomyopathy and heart failure comprising NF-κB inhibitor as an active ingredient |
US20010018446A1 (en) | 1999-09-23 | 2001-08-30 | G.D. Searle & Co. | Substituted N-Aliphatic-N-Aromatictertiary-Heteroalkylamines useful for inhibiting cholesteryl ester transfer protein activity |
US7718674B2 (en) | 2004-09-27 | 2010-05-18 | Bridge Pharma, Inc. | Methods of relieving neuropathic pain with the S-isomer of 2-{2[N-(2-indanyl)-N-phenylamino]ethyl}piperidine |
US7592458B2 (en) | 2006-07-21 | 2009-09-22 | Wright George E | Dermal anesthetic compounds and pharmaceutical compositions for inducing local anesthesia and mitigating neuropathic pain |
-
1973
- 1973-01-01 AR AR250138A patent/AR206505A1/en active
- 1973-03-01 GB GB998773*[A patent/GB1405444A/en not_active Expired
- 1973-09-13 IL IL43218A patent/IL43218A/en unknown
- 1973-09-14 CA CA180,979A patent/CA992547A/en not_active Expired
- 1973-09-17 DD DD173520A patent/DD108277A5/xx unknown
- 1973-09-17 CH CH1330973A patent/CH585690A5/xx not_active IP Right Cessation
- 1973-09-17 LU LU68426A patent/LU68426A1/xx unknown
- 1973-09-17 HU HUCI1409A patent/HU168018B/hu unknown
- 1973-09-17 NL NL737312776A patent/NL152246B/en not_active IP Right Cessation
- 1973-09-17 ES ES418827A patent/ES418827A1/en not_active Expired
- 1973-09-17 DD DD175711A patent/DD109802A5/xx unknown
- 1973-09-18 FR FR7333497A patent/FR2199988B1/fr not_active Expired
- 1973-09-18 MX MX146573U patent/MX3233E/en unknown
- 1973-09-18 JP JP10583673A patent/JPS5327263B2/ja not_active Expired
-
1974
- 1974-01-01 AR AR254382A patent/AR204247A1/en active
- 1974-01-01 AR AR254383A patent/AR205891A1/en active
-
1975
- 1975-02-05 AR AR257533A patent/AR203500A1/en active
- 1975-08-05 ES ES440029A patent/ES440029A1/en not_active Expired
- 1975-08-05 ES ES440030A patent/ES440030A1/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
JPS4969648A (en) | 1974-07-05 |
DE2346337B2 (en) | 1976-08-26 |
IL43218A (en) | 1977-05-31 |
ES418827A1 (en) | 1977-02-01 |
FR2199988B1 (en) | 1977-11-25 |
AR205891A1 (en) | 1976-06-15 |
AR204247A1 (en) | 1975-12-10 |
NL7312776A (en) | 1974-03-20 |
ES440030A1 (en) | 1977-02-16 |
GB1405444A (en) | 1975-09-10 |
DE2346337A1 (en) | 1974-04-04 |
JPS5327263B2 (en) | 1978-08-07 |
DD108277A5 (en) | 1974-09-12 |
AR206505A1 (en) | 1976-07-30 |
IL43218A0 (en) | 1973-11-28 |
CH585690A5 (en) | 1977-03-15 |
DD109802A5 (en) | 1974-11-20 |
CA992547A (en) | 1976-07-06 |
AU6028373A (en) | 1975-03-13 |
AR203500A1 (en) | 1975-09-15 |
FR2199988A1 (en) | 1974-04-19 |
MX3233E (en) | 1980-08-05 |
NL152246B (en) | 1977-02-15 |
LU68426A1 (en) | 1973-11-26 |
HU168018B (en) | 1976-02-28 |
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