ES418827A1 - 2-aminoindane derivatives - Google Patents

2-aminoindane derivatives

Info

Publication number
ES418827A1
ES418827A1 ES418827A ES418827A ES418827A1 ES 418827 A1 ES418827 A1 ES 418827A1 ES 418827 A ES418827 A ES 418827A ES 418827 A ES418827 A ES 418827A ES 418827 A1 ES418827 A1 ES 418827A1
Authority
ES
Spain
Prior art keywords
formula
radical
see formula
compound
see
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES418827A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MANUF PROD PHARMA
Original Assignee
MANUF PROD PHARMA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MANUF PROD PHARMA filed Critical MANUF PROD PHARMA
Publication of ES418827A1 publication Critical patent/ES418827A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)

Abstract

A procedure to prepare new 2-aminoindane derivatives of the general formula: **(See formula)** in which n is equal to 2, 3 or 4, with the group (CH2) n having a straight chain in which one or more hydrogen atoms may be replaced by a hydroxyl radical, R1 represents a lower alcohol radical or lower hydroxyalkoyl radical than contains 1 to 4 carbon atoms or a lower alkenyl or lower alkynyl radical containing 2 or 3 carbon atoms, A is an unsubstituted phenyl radical or a substituted phenyl radical with at least one substituent at the ortho, meta and/positions or for, as well as the acid addition salts of said derivatives of formula I, comprising, reacting an N-phenyl- [5 N- (2-pyridyl)] - 2-aminoindane of the formula: **(See formula)** in which A has the same meaning defined above, with an acid chloride **(See formula)** in which n'is equal to 1, 2 or 3, in order to obtain an acylated compound of the formula **(See formula)** the latter compound being acylated then reduced by means of lithium aluminum hydride, and alkoxylated by means of a primary amine of formula **(See formula)** in which R1 has the meaning defined above, the reduction and alkoxylation reactions can be carried out in any order, and the compound of formula I obtained being transformed, if necessary, into an acid addition salt. (Machine-translation by Google Translate, not legally binding)
ES418827A 1972-09-18 1973-09-17 2-aminoindane derivatives Expired ES418827A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB4315072 1972-09-18
GB998873 1973-03-01
GB998773*[A GB1405444A (en) 1972-09-18 1973-03-01 2-aminoindane derivatives
GB1030373 1973-03-02

Publications (1)

Publication Number Publication Date
ES418827A1 true ES418827A1 (en) 1977-02-01

Family

ID=27447738

Family Applications (3)

Application Number Title Priority Date Filing Date
ES418827A Expired ES418827A1 (en) 1972-09-18 1973-09-17 2-aminoindane derivatives
ES440029A Expired ES440029A1 (en) 1972-09-18 1975-08-05 2-aminoindane derivatives
ES440030A Expired ES440030A1 (en) 1972-09-18 1975-08-05 2-aminoindane derivatives

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES440029A Expired ES440029A1 (en) 1972-09-18 1975-08-05 2-aminoindane derivatives
ES440030A Expired ES440030A1 (en) 1972-09-18 1975-08-05 2-aminoindane derivatives

Country Status (13)

Country Link
JP (1) JPS5327263B2 (en)
AR (4) AR206505A1 (en)
CA (1) CA992547A (en)
CH (1) CH585690A5 (en)
DD (2) DD109802A5 (en)
ES (3) ES418827A1 (en)
FR (1) FR2199988B1 (en)
GB (1) GB1405444A (en)
HU (1) HU168018B (en)
IL (1) IL43218A (en)
LU (1) LU68426A1 (en)
MX (1) MX3233E (en)
NL (1) NL152246B (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4975461A (en) * 1986-06-19 1990-12-04 E. R. Squibb & Sons, Inc. P-aminophenols, derivatives thereof and method of use
JPH0293610U (en) * 1989-01-09 1990-07-25
EP1658847A3 (en) * 1999-06-10 2006-07-26 Bridge Pharma, Inc. Indane derivatives as dermal anesthetic agents
US6413987B1 (en) * 1999-06-10 2002-07-02 Bridge Pharma, Inc. Dermal anesthetic agents
EP1132093A4 (en) 1999-09-17 2006-04-19 Daiichi Suntory Pharma Co Ltd Preventives or remedies for myocarditis, dilated cardiomyopathy and cardiac insufficiency containing nf-kappa b inhibitors as the active ingredient
US20010018446A1 (en) 1999-09-23 2001-08-30 G.D. Searle & Co. Substituted N-Aliphatic-N-Aromatictertiary-Heteroalkylamines useful for inhibiting cholesteryl ester transfer protein activity
WO2006036936A2 (en) 2004-09-27 2006-04-06 Bridge Pharma, Inc. The s-isomer of 2-{2-[n-(2-indanyl)-n-phenylamino]ethyl}piperidine and other dermal anesthetic agents
CA2655809C (en) 2006-07-21 2013-10-01 Bridge Pharma, Inc. Dermal anesthetic compounds

Also Published As

Publication number Publication date
GB1405444A (en) 1975-09-10
ES440029A1 (en) 1977-02-16
NL7312776A (en) 1974-03-20
DE2346337A1 (en) 1974-04-04
AR204247A1 (en) 1975-12-10
CA992547A (en) 1976-07-06
LU68426A1 (en) 1973-11-26
FR2199988A1 (en) 1974-04-19
DD108277A5 (en) 1974-09-12
JPS5327263B2 (en) 1978-08-07
IL43218A (en) 1977-05-31
DD109802A5 (en) 1974-11-20
DE2346337B2 (en) 1976-08-26
CH585690A5 (en) 1977-03-15
AR203500A1 (en) 1975-09-15
NL152246B (en) 1977-02-15
FR2199988B1 (en) 1977-11-25
IL43218A0 (en) 1973-11-28
HU168018B (en) 1976-02-28
JPS4969648A (en) 1974-07-05
AR206505A1 (en) 1976-07-30
AR205891A1 (en) 1976-06-15
AU6028373A (en) 1975-03-13
ES440030A1 (en) 1977-02-16
MX3233E (en) 1980-08-05

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19840326