ES307300A1 - Procedure for the preparation of new substitute 6,7-benzomorphanes. (Machine-translation by Google Translate, not legally binding) - Google Patents

Procedure for the preparation of new substitute 6,7-benzomorphanes. (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES307300A1
ES307300A1 ES0307300A ES307300A ES307300A1 ES 307300 A1 ES307300 A1 ES 307300A1 ES 0307300 A ES0307300 A ES 0307300A ES 307300 A ES307300 A ES 307300A ES 307300 A1 ES307300 A1 ES 307300A1
Authority
ES
Spain
Prior art keywords
radical
formula
translation
preparation
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES0307300A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
JR Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by JR Geigy AG filed Critical JR Geigy AG
Publication of ES307300A1 publication Critical patent/ES307300A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/82—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/26—Benzomorphans

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Discharge Lamp (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Process for the preparation of new substituted 6,7-benzomorpans of the general formula I ** (See formula) ** in which X means oxygen or sulfur, R1 means hydrogen, the hydroxyl group, an alkoxy or lower alkanoyloxy radical, R 2 means hydrogen, an alkyl or lower beta-methoxyethyl radical or a phenyl radical optionally substituted by a halogen atom, a hydroxyl group or an alkyl, alkanoyloxy or lower alkoxy group, R3 means hydrogen or a lower alkyl radical, R4 means, hydrogen, a lower alkyl radical, a lower alkenyl radical, a phenyl, chlorophenyl or bromophenyl radical or a phenylalkyl radical, and its acid addition salts, characterized in that a compound of the general formula II, ** (See formula) ** wherein R1, R2 and R3 have the significance indicated in formula I, is reacted with a compound of the general formula III R4+N=C=X where X and R4 have the same significance indicated in formula I, and, if desired, the compound thus obtained is transformed into an acid addition salt. (Machine-translation by Google Translate, not legally binding)
ES0307300A 1963-12-20 1964-12-19 Procedure for the preparation of new substitute 6,7-benzomorphanes. (Machine-translation by Google Translate, not legally binding) Expired ES307300A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US33229663A 1963-12-20 1963-12-20

Publications (1)

Publication Number Publication Date
ES307300A1 true ES307300A1 (en) 1965-05-01

Family

ID=23297612

Family Applications (4)

Application Number Title Priority Date Filing Date
ES0307300A Expired ES307300A1 (en) 1963-12-20 1964-12-19 Procedure for the preparation of new substitute 6,7-benzomorphanes. (Machine-translation by Google Translate, not legally binding)
ES0307302A Expired ES307302A1 (en) 1963-12-20 1964-12-19 Procedure for preparing new substituteed 6,7-benzomorphanes. (Machine-translation by Google Translate, not legally binding)
ES0307301A Expired ES307301A1 (en) 1963-12-20 1964-12-19 Benzomorphans and process for their preparation
ES0307299A Expired ES307299A1 (en) 1963-12-20 1964-12-19 Procedure for the preparation of substitute 6,7-benzomorphanes. (Machine-translation by Google Translate, not legally binding)

Family Applications After (3)

Application Number Title Priority Date Filing Date
ES0307302A Expired ES307302A1 (en) 1963-12-20 1964-12-19 Procedure for preparing new substituteed 6,7-benzomorphanes. (Machine-translation by Google Translate, not legally binding)
ES0307301A Expired ES307301A1 (en) 1963-12-20 1964-12-19 Benzomorphans and process for their preparation
ES0307299A Expired ES307299A1 (en) 1963-12-20 1964-12-19 Procedure for the preparation of substitute 6,7-benzomorphanes. (Machine-translation by Google Translate, not legally binding)

Country Status (12)

Country Link
AT (4) AT249277B (en)
BE (2) BE657405A (en)
CH (7) CH449643A (en)
DE (2) DE1445853A1 (en)
DK (4) DK108497C (en)
ES (4) ES307300A1 (en)
FR (2) FR4345M (en)
GB (2) GB1077711A (en)
IL (2) IL22642A (en)
NL (3) NL6414820A (en)
NO (2) NO119273B (en)
SE (2) SE322779B (en)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7501433B2 (en) 2002-05-17 2009-03-10 Jenken Biosciences, Inc. Opioid and opioid-like compounds and uses thereof
US7923454B2 (en) 2002-05-17 2011-04-12 Jenken Biosciences, Inc. Opioid and opioid-like compounds and uses thereof
EP2987788A1 (en) 2002-05-17 2016-02-24 Taiwanj Pharmaceuticals Co., Ltd. Opioid and opioid-like compounds and uses thereof
US8017622B2 (en) 2003-05-16 2011-09-13 Jenken Biosciences, Inc. Opioid and opioid-like compounds and uses thereof
JP5486928B2 (en) 2007-02-26 2014-05-07 ヴァイティー ファーマシューティカルズ，インコーポレイテッド Cyclic urea and carbamate inhibitors of 11β-hydroxysteroid dehydrogenase 1
JP5451611B2 (en) 2007-07-26 2014-03-26 ヴァイティー ファーマシューティカルズ，インコーポレイテッド Cyclic inhibitor of 11β-hydroxysteroid dehydrogenase 1
AR069207A1 (en) 2007-11-07 2010-01-06 Vitae Pharmaceuticals Inc CYCLIC UREAS AS INHIBITORS OF THE 11 BETA - HIDROXI-ESTEROIDE DESHIDROGENASA 1
CA2704628C (en) 2007-11-16 2016-11-29 Boehringer Ingelheim International Gmbh Aryl- and heteroarylcarbonyl derivatives of benzomorphanes and related scaffolds, medicaments containing such compounds and their use
WO2009075835A1 (en) 2007-12-11 2009-06-18 Vitae Pharmaceutical, Inc CYCLIC UREA INHIBITORS OF 11β-HYDROXYSTEROID DEHYDROGENASE 1
TW200934490A (en) 2008-01-07 2009-08-16 Vitae Pharmaceuticals Inc Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1
JP5490020B2 (en) 2008-01-24 2014-05-14 ヴァイティー ファーマシューティカルズ，インコーポレイテッド Cyclic carbazate and semicarbazide inhibitors of 11β-hydroxysteroid dehydrogenase 1
JP5734666B2 (en) 2008-02-11 2015-06-17 ヴァイティー ファーマシューティカルズ，インコーポレイテッド 1,3-oxaazepan-2-one and 1,3-diazepan-2-one inhibitors of 11β-hydroxysteroid dehydrogenase 1
US20110028445A1 (en) * 2008-02-12 2011-02-03 Boehringer Ingelheim International Gmbh Urea derivatives of benzomorphanes and related scaffolds, medicaments containing such compounds and their use
US8598160B2 (en) 2008-02-15 2013-12-03 Vitae Pharmaceuticals, Inc. Cycloalkyl lactame derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
JP5538365B2 (en) 2008-05-01 2014-07-02 ヴァイティー ファーマシューティカルズ，インコーポレイテッド Cyclic inhibitor of 11β-hydroxysteroid dehydrogenase 1
US8242111B2 (en) 2008-05-01 2012-08-14 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1
CL2009001058A1 (en) 2008-05-01 2010-09-10 Vitae Pharmaceuticals Inc Compounds derived from substituted oxazines, inhibitors of 11b-hydroxysteroid dehydrogenase type-1; pharmaceutical composition; and use of the compound to inhibit the activity of 11b-hsd1, as in the treatment of diabetes, dyslipidemia, hypertension, obesity, cancer, glaucoma, among others.
PL2300461T3 (en) 2008-05-01 2013-09-30 Vitae Pharmaceuticals Inc Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
US8765780B2 (en) 2008-05-13 2014-07-01 Boehringer Ingelheim International Gmbh Alicyclic carboxylic acid derivatives of benzomorphans and related scaffolds, medicaments containing such compounds and their use
CA2729998A1 (en) 2008-07-25 2010-01-28 Boehringer Ingelheim International Gmbh Inhibitors of 11beta-hydroxysteroid dehydrogenase 1
EP2687525B1 (en) 2008-07-25 2015-09-23 Boehringer Ingelheim International GmbH Cyclic inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
WO2010046445A2 (en) 2008-10-23 2010-04-29 Boehringer Ingelheim International Gmbh Urea derivatives of substituted nortropanes, medicaments containing such compounds and their use
WO2010089303A1 (en) 2009-02-04 2010-08-12 Boehringer Ingelheim International Gmbh CYCLIC INHIBITORS OF 11 β-HYDROXYSTEROID DEHYDROGENASE 1
UA109255C2 (en) 2009-04-30 2015-08-10 Берінгер Інгельхайм Інтернешнл Гмбх Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
WO2010139673A1 (en) 2009-06-02 2010-12-09 Boehringer Ingelheim International Gmbh Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
US8927539B2 (en) 2009-06-11 2015-01-06 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1 based on the 1,3-oxazinan-2-one structure
EP2448928B1 (en) 2009-07-01 2014-08-13 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
AR078887A1 (en) 2009-11-06 2011-12-07 Boehringer Ingelheim Int ARILO AND HETEROARILCARBONILO DERIVATIVES OF HEXAHYDROINDENOPIRIDINE AND OCTAHYDROBENZOQUINOLINE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
JP5860042B2 (en) 2010-06-16 2016-02-16 ヴァイティー ファーマシューティカルズ，インコーポレイテッド Substituted 5, 6 and 7 membered heterocycles, medicaments containing such compounds and their use
WO2011161128A1 (en) 2010-06-25 2011-12-29 Boehringer Ingelheim International Gmbh Azaspirohexanones as inhibitors of 11-beta-hsd1 for the treatment of metabolic disorders
WO2012059416A1 (en) 2010-11-02 2012-05-10 Boehringer Ingelheim International Gmbh Pharmaceutical combinations for the treatment of metabolic disorders
TWI537258B (en) 2010-11-05 2016-06-11 百靈佳殷格翰國際股份有限公司 Aryl-and heteroarylcarbonyl derivatives of hexahydroindenopyridine and octahydrobenzoquinoline
JP2014524438A (en) 2011-08-17 2014-09-22 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Indenopyridine derivatives

Also Published As

Publication number Publication date
DE1445854A1 (en) 1968-12-05
AT249277B (en) 1966-09-12
ES307301A1 (en) 1965-05-16
GB1092394A (en) 1967-11-22
DK108495C (en) 1967-12-27
CH448118A (en) 1967-12-15
NL6414820A (en) 1965-06-21
DK108496C (en) 1967-12-27
ES307302A1 (en) 1965-05-16
DK108497C (en) 1967-12-27
CH449640A (en) 1968-01-15
SE305657B (en) 1968-11-04
AT253687B (en) 1967-04-25
GB1077711A (en) 1967-08-02
NO119274B (en) 1970-04-27
ES307299A1 (en) 1965-05-16
DK106552C (en) 1967-02-20
SE322779B (en) 1970-04-20
BE657405A (en) 1965-06-21
IL22643A (en) 1968-07-25
IL22642A (en) 1968-07-25
AT249276B (en) 1966-09-12
NO119273B (en) 1970-04-27
NL127995C (en)
BE657406A (en) 1965-06-21
NL6414821A (en) 1965-06-21
CH449639A (en) 1968-01-15
FR4345M (en) 1966-08-16
CH449642A (en) 1968-01-15
DE1445853A1 (en) 1968-12-05
CH449643A (en) 1968-01-15
FR4346M (en) 1966-08-16
CH449641A (en) 1968-01-15
AT261126B (en) 1968-04-10
CH446371A (en) 1967-11-15

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