ES307299A1 - Procedure for the preparation of substitute 6,7-benzomorphanes. (Machine-translation by Google Translate, not legally binding) - Google Patents
Procedure for the preparation of substitute 6,7-benzomorphanes. (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES307299A1 ES307299A1 ES0307299A ES307299A ES307299A1 ES 307299 A1 ES307299 A1 ES 307299A1 ES 0307299 A ES0307299 A ES 0307299A ES 307299 A ES307299 A ES 307299A ES 307299 A1 ES307299 A1 ES 307299A1
- Authority
- ES
- Spain
- Prior art keywords
- compound
- general formula
- radical
- group
- radicals
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/82—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
- C07D221/26—Benzomorphans
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Discharge Lamp (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Process for the preparation of substituted 6,7-benzomorpans, of the general formula I, ** (See formula) ** in which X means oxygen or sulfur, R1 means hydrogen, the hydroxy group, an alkoxy or lower alkanoyloxy radical, R 2 represents hydrogen, an alkyl or lower beta-methoxy-ethyl radical or a phenyl radical optionally substituted by a halogen atom, a hydroxyl group or an alkyl, alkanoyloxy or lower alkoxy group, R3 means hydrogen or a lower alkyl radical, R4 and R5 mean, independently of one another, hydrogen, lower alkyl radicals, lower alkenyl radicals, phenyl, chlorophenyl or bromophenyl radicals or phenylalkyl radicals, or R4 and R5 mean, together with the adjacent nitrogen atom, a saturated heterocycle with at most 7 carbon atoms or a morpholino radical, and its acid addition salts, characterized in that a compound of the general formula II, ** (See formula) ** wherein R1, R2 and R3 have the meaning stated above, it is reacted in the presence of an acid-binding agent with phosgene and an amine of the general formula III, ** (See formula) ** or with a compound of the general formula IIIa, ** (See formula) ** in which formulas R4 and R5 have the significance stated above and Hal means a halogen atom, and, if desired, a compound thus obtained with X = O is transformed into one such compound with X = S, as well as, if desired, a compound of the general formula I, wherein R 1 signifies the hydroxylic group, it is alkylated or alkanoylated in a manner known per se, or in the case that R1 means an alkoxy or lower alkanoyloxy group is hydrolyzed in a manner known per se, and furthermore, if desired, a compound of the general formula I is transformed in an acid addition salt. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33229663A | 1963-12-20 | 1963-12-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES307299A1 true ES307299A1 (en) | 1965-05-16 |
Family
ID=23297612
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES0307300A Expired ES307300A1 (en) | 1963-12-20 | 1964-12-19 | Procedure for the preparation of new substitute 6,7-benzomorphanes. (Machine-translation by Google Translate, not legally binding) |
| ES0307302A Expired ES307302A1 (en) | 1963-12-20 | 1964-12-19 | Procedure for preparing new substituteed 6,7-benzomorphanes. (Machine-translation by Google Translate, not legally binding) |
| ES0307301A Expired ES307301A1 (en) | 1963-12-20 | 1964-12-19 | Benzomorphans and process for their preparation |
| ES0307299A Expired ES307299A1 (en) | 1963-12-20 | 1964-12-19 | Procedure for the preparation of substitute 6,7-benzomorphanes. (Machine-translation by Google Translate, not legally binding) |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES0307300A Expired ES307300A1 (en) | 1963-12-20 | 1964-12-19 | Procedure for the preparation of new substitute 6,7-benzomorphanes. (Machine-translation by Google Translate, not legally binding) |
| ES0307302A Expired ES307302A1 (en) | 1963-12-20 | 1964-12-19 | Procedure for preparing new substituteed 6,7-benzomorphanes. (Machine-translation by Google Translate, not legally binding) |
| ES0307301A Expired ES307301A1 (en) | 1963-12-20 | 1964-12-19 | Benzomorphans and process for their preparation |
Country Status (12)
| Country | Link |
|---|---|
| AT (4) | AT249277B (en) |
| BE (2) | BE657405A (en) |
| CH (7) | CH449643A (en) |
| DE (2) | DE1445853A1 (en) |
| DK (4) | DK108497C (en) |
| ES (4) | ES307300A1 (en) |
| FR (2) | FR4345M (en) |
| GB (2) | GB1077711A (en) |
| IL (2) | IL22642A (en) |
| NL (3) | NL6414820A (en) |
| NO (2) | NO119273B (en) |
| SE (2) | SE322779B (en) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7501433B2 (en) | 2002-05-17 | 2009-03-10 | Jenken Biosciences, Inc. | Opioid and opioid-like compounds and uses thereof |
| US7923454B2 (en) | 2002-05-17 | 2011-04-12 | Jenken Biosciences, Inc. | Opioid and opioid-like compounds and uses thereof |
| EP2987788A1 (en) | 2002-05-17 | 2016-02-24 | Taiwanj Pharmaceuticals Co., Ltd. | Opioid and opioid-like compounds and uses thereof |
| US8017622B2 (en) | 2003-05-16 | 2011-09-13 | Jenken Biosciences, Inc. | Opioid and opioid-like compounds and uses thereof |
| JP5486928B2 (en) | 2007-02-26 | 2014-05-07 | ヴァイティー ファーマシューティカルズ，インコーポレイテッド | Cyclic urea and carbamate inhibitors of 11β-hydroxysteroid dehydrogenase 1 |
| JP5451611B2 (en) | 2007-07-26 | 2014-03-26 | ヴァイティー ファーマシューティカルズ，インコーポレイテッド | Cyclic inhibitor of 11β-hydroxysteroid dehydrogenase 1 |
| AR069207A1 (en) | 2007-11-07 | 2010-01-06 | Vitae Pharmaceuticals Inc | CYCLIC UREAS AS INHIBITORS OF THE 11 BETA - HIDROXI-ESTEROIDE DESHIDROGENASA 1 |
| CA2704628C (en) | 2007-11-16 | 2016-11-29 | Boehringer Ingelheim International Gmbh | Aryl- and heteroarylcarbonyl derivatives of benzomorphanes and related scaffolds, medicaments containing such compounds and their use |
| WO2009075835A1 (en) | 2007-12-11 | 2009-06-18 | Vitae Pharmaceutical, Inc | CYCLIC UREA INHIBITORS OF 11β-HYDROXYSTEROID DEHYDROGENASE 1 |
| TW200934490A (en) | 2008-01-07 | 2009-08-16 | Vitae Pharmaceuticals Inc | Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1 |
| JP5490020B2 (en) | 2008-01-24 | 2014-05-14 | ヴァイティー ファーマシューティカルズ，インコーポレイテッド | Cyclic carbazate and semicarbazide inhibitors of 11β-hydroxysteroid dehydrogenase 1 |
| JP5734666B2 (en) | 2008-02-11 | 2015-06-17 | ヴァイティー ファーマシューティカルズ，インコーポレイテッド | 1,3-oxaazepan-2-one and 1,3-diazepan-2-one inhibitors of 11β-hydroxysteroid dehydrogenase 1 |
| US20110028445A1 (en) * | 2008-02-12 | 2011-02-03 | Boehringer Ingelheim International Gmbh | Urea derivatives of benzomorphanes and related scaffolds, medicaments containing such compounds and their use |
| US8598160B2 (en) | 2008-02-15 | 2013-12-03 | Vitae Pharmaceuticals, Inc. | Cycloalkyl lactame derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
| JP5538365B2 (en) | 2008-05-01 | 2014-07-02 | ヴァイティー ファーマシューティカルズ，インコーポレイテッド | Cyclic inhibitor of 11β-hydroxysteroid dehydrogenase 1 |
| US8242111B2 (en) | 2008-05-01 | 2012-08-14 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1 |
| CL2009001058A1 (en) | 2008-05-01 | 2010-09-10 | Vitae Pharmaceuticals Inc | Compounds derived from substituted oxazines, inhibitors of 11b-hydroxysteroid dehydrogenase type-1; pharmaceutical composition; and use of the compound to inhibit the activity of 11b-hsd1, as in the treatment of diabetes, dyslipidemia, hypertension, obesity, cancer, glaucoma, among others. |
| PL2300461T3 (en) | 2008-05-01 | 2013-09-30 | Vitae Pharmaceuticals Inc | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| US8765780B2 (en) | 2008-05-13 | 2014-07-01 | Boehringer Ingelheim International Gmbh | Alicyclic carboxylic acid derivatives of benzomorphans and related scaffolds, medicaments containing such compounds and their use |
| CA2729998A1 (en) | 2008-07-25 | 2010-01-28 | Boehringer Ingelheim International Gmbh | Inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| EP2687525B1 (en) | 2008-07-25 | 2015-09-23 | Boehringer Ingelheim International GmbH | Cyclic inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
| WO2010046445A2 (en) | 2008-10-23 | 2010-04-29 | Boehringer Ingelheim International Gmbh | Urea derivatives of substituted nortropanes, medicaments containing such compounds and their use |
| WO2010089303A1 (en) | 2009-02-04 | 2010-08-12 | Boehringer Ingelheim International Gmbh | CYCLIC INHIBITORS OF 11 β-HYDROXYSTEROID DEHYDROGENASE 1 |
| UA109255C2 (en) | 2009-04-30 | 2015-08-10 | Берінгер Інгельхайм Інтернешнл Гмбх | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| WO2010139673A1 (en) | 2009-06-02 | 2010-12-09 | Boehringer Ingelheim International Gmbh | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| US8927539B2 (en) | 2009-06-11 | 2015-01-06 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1 based on the 1,3-oxazinan-2-one structure |
| EP2448928B1 (en) | 2009-07-01 | 2014-08-13 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| AR078887A1 (en) | 2009-11-06 | 2011-12-07 | Boehringer Ingelheim Int | ARILO AND HETEROARILCARBONILO DERIVATIVES OF HEXAHYDROINDENOPIRIDINE AND OCTAHYDROBENZOQUINOLINE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. |
| JP5860042B2 (en) | 2010-06-16 | 2016-02-16 | ヴァイティー ファーマシューティカルズ，インコーポレイテッド | Substituted 5, 6 and 7 membered heterocycles, medicaments containing such compounds and their use |
| WO2011161128A1 (en) | 2010-06-25 | 2011-12-29 | Boehringer Ingelheim International Gmbh | Azaspirohexanones as inhibitors of 11-beta-hsd1 for the treatment of metabolic disorders |
| WO2012059416A1 (en) | 2010-11-02 | 2012-05-10 | Boehringer Ingelheim International Gmbh | Pharmaceutical combinations for the treatment of metabolic disorders |
| TWI537258B (en) | 2010-11-05 | 2016-06-11 | 百靈佳殷格翰國際股份有限公司 | Aryl-and heteroarylcarbonyl derivatives of hexahydroindenopyridine and octahydrobenzoquinoline |
| JP2014524438A (en) | 2011-08-17 | 2014-09-22 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Indenopyridine derivatives |
-
0
- NL NL127995D patent/NL127995C/xx active
-
1964
- 1964-11-30 CH CH1619167A patent/CH449643A/en unknown
- 1964-11-30 CH CH1538464A patent/CH446371A/en unknown
- 1964-11-30 CH CH1618967A patent/CH449641A/en unknown
- 1964-11-30 CH CH1618767A patent/CH449639A/en unknown
- 1964-11-30 CH CH1538364A patent/CH448118A/en unknown
- 1964-11-30 CH CH1618867A patent/CH449640A/en unknown
- 1964-11-30 CH CH1619067A patent/CH449642A/en unknown
- 1964-12-18 GB GB5149864A patent/GB1077711A/en not_active Expired
- 1964-12-18 AT AT392965A patent/AT249277B/en active
- 1964-12-18 AT AT1074364A patent/AT253687B/en active
- 1964-12-18 IL IL2264264A patent/IL22642A/en unknown
- 1964-12-18 DE DE19641445853 patent/DE1445853A1/en active Pending
- 1964-12-18 SE SE1536064A patent/SE322779B/xx unknown
- 1964-12-18 AT AT1074264A patent/AT261126B/en active
- 1964-12-18 SE SE1536164A patent/SE305657B/xx unknown
- 1964-12-18 GB GB5150064A patent/GB1092394A/en not_active Expired
- 1964-12-18 IL IL2264364A patent/IL22643A/en unknown
- 1964-12-18 DE DE19641445854 patent/DE1445854A1/en active Pending
- 1964-12-18 NL NL6414820A patent/NL6414820A/xx unknown
- 1964-12-18 NL NL6414821A patent/NL6414821A/xx unknown
- 1964-12-18 AT AT392865A patent/AT249276B/en active
- 1964-12-19 DK DK429865A patent/DK108497C/en active
- 1964-12-19 DK DK626864A patent/DK106552C/en active
- 1964-12-19 DK DK429765A patent/DK108496C/en active
- 1964-12-19 ES ES0307300A patent/ES307300A1/en not_active Expired
- 1964-12-19 NO NO15606264A patent/NO119273B/no unknown
- 1964-12-19 ES ES0307302A patent/ES307302A1/en not_active Expired
- 1964-12-19 ES ES0307301A patent/ES307301A1/en not_active Expired
- 1964-12-19 ES ES0307299A patent/ES307299A1/en not_active Expired
- 1964-12-19 DK DK626764A patent/DK108495C/en active
- 1964-12-19 NO NO15606364A patent/NO119274B/no unknown
- 1964-12-21 BE BE657405D patent/BE657405A/xx unknown
- 1964-12-21 BE BE657406D patent/BE657406A/xx unknown
-
1965
- 1965-03-19 FR FR9865A patent/FR4345M/fr active Active
- 1965-03-19 FR FR9866A patent/FR4346M/fr active Active
Also Published As
| Publication number | Publication date |
|---|---|
| DE1445854A1 (en) | 1968-12-05 |
| AT249277B (en) | 1966-09-12 |
| ES307301A1 (en) | 1965-05-16 |
| GB1092394A (en) | 1967-11-22 |
| DK108495C (en) | 1967-12-27 |
| CH448118A (en) | 1967-12-15 |
| NL6414820A (en) | 1965-06-21 |
| DK108496C (en) | 1967-12-27 |
| ES307302A1 (en) | 1965-05-16 |
| DK108497C (en) | 1967-12-27 |
| CH449640A (en) | 1968-01-15 |
| SE305657B (en) | 1968-11-04 |
| AT253687B (en) | 1967-04-25 |
| GB1077711A (en) | 1967-08-02 |
| NO119274B (en) | 1970-04-27 |
| DK106552C (en) | 1967-02-20 |
| SE322779B (en) | 1970-04-20 |
| BE657405A (en) | 1965-06-21 |
| IL22643A (en) | 1968-07-25 |
| IL22642A (en) | 1968-07-25 |
| AT249276B (en) | 1966-09-12 |
| NO119273B (en) | 1970-04-27 |
| NL127995C (en) | |
| BE657406A (en) | 1965-06-21 |
| NL6414821A (en) | 1965-06-21 |
| CH449639A (en) | 1968-01-15 |
| FR4345M (en) | 1966-08-16 |
| CH449642A (en) | 1968-01-15 |
| DE1445853A1 (en) | 1968-12-05 |
| CH449643A (en) | 1968-01-15 |
| FR4346M (en) | 1966-08-16 |
| CH449641A (en) | 1968-01-15 |
| AT261126B (en) | 1968-04-10 |
| CH446371A (en) | 1967-11-15 |
| ES307300A1 (en) | 1965-05-01 |
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