ES446239A1 - 8-azaprostaglandins and process for the preparation thereof - Google Patents

8-azaprostaglandins and process for the preparation thereof

Info

Publication number
ES446239A1
ES446239A1 ES446239A ES446239A ES446239A1 ES 446239 A1 ES446239 A1 ES 446239A1 ES 446239 A ES446239 A ES 446239A ES 446239 A ES446239 A ES 446239A ES 446239 A1 ES446239 A1 ES 446239A1
Authority
ES
Spain
Prior art keywords
formula
prostaglandin derivative
azaprostaglandins
preparation
see
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES446239A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Labaz SA
Original Assignee
Labaz SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Labaz SA filed Critical Labaz SA
Publication of ES446239A1 publication Critical patent/ES446239A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/04—Saturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/16—Saturated compounds containing keto groups bound to acyclic carbon atoms containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/377—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups
    • C07C51/38—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups by decarboxylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/185—Saturated compounds having only one carboxyl group and containing keto groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F1/00—Compounds containing elements of Groups 1 or 11 of the Periodic System
    • C07F1/005—Compounds containing elements of Groups 1 or 11 of the Periodic System without C-Metal linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/54—Quaternary phosphonium compounds
    • C07F9/5407—Acyclic saturated phosphonium compounds

Abstract

Procedure to prepare a prostaglandin derivative, of formula: ** (See formula) ** characterized in that it comprises saponifying an ester of the general formula: ** (See formula) ** wherein R1 represents a linear or branched alkyl group containing 1 to 7 carbon atoms, in an alcoholic medium, with an alkali, and hydrolyzing the resulting alkali metal salt of the compound of formula II with a strong acid, to form the desired prostaglandin derivative. (Machine-translation by Google Translate, not legally binding)
ES446239A 1975-03-21 1976-03-20 8-azaprostaglandins and process for the preparation thereof Expired ES446239A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB12034/75A GB1529852A (en) 1975-03-21 1975-03-21 8-azaprostaglandins and process for the preparation thereof

Publications (1)

Publication Number Publication Date
ES446239A1 true ES446239A1 (en) 1977-07-01

Family

ID=9997230

Family Applications (2)

Application Number Title Priority Date Filing Date
ES446239A Expired ES446239A1 (en) 1975-03-21 1976-03-20 8-azaprostaglandins and process for the preparation thereof
ES458389A Expired ES458389A1 (en) 1975-03-21 1977-05-03 8-azaprostaglandins and process for the preparation thereof

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES458389A Expired ES458389A1 (en) 1975-03-21 1977-05-03 8-azaprostaglandins and process for the preparation thereof

Country Status (26)

Country Link
JP (1) JPS607602B2 (en)
AR (1) AR213172A1 (en)
AT (1) AT348163B (en)
AU (1) AU501105B2 (en)
BE (1) BE839761A (en)
CA (1) CA1076587A (en)
CH (2) CH611604A5 (en)
DE (1) DE2612114A1 (en)
DK (1) DK140937B (en)
ES (2) ES446239A1 (en)
FI (1) FI61692C (en)
FR (1) FR2304340A1 (en)
GB (1) GB1529852A (en)
HU (1) HU173348B (en)
IE (1) IE42966B1 (en)
IT (1) IT1061011B (en)
MX (1) MX3301E (en)
NL (1) NL7602891A (en)
NO (1) NO144147C (en)
NZ (1) NZ180251A (en)
OA (1) OA05279A (en)
PT (1) PT64919B (en)
SE (1) SE418290B (en)
SU (1) SU614746A3 (en)
YU (1) YU73876A (en)
ZA (1) ZA761448B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4097489A (en) * 1977-06-17 1978-06-27 The Upjohn Company 9-Deoxy-9α,6-nitrilo or 6,9α-imino-PGF compounds
US5540618A (en) * 1994-10-28 1996-07-30 National University Of Singapore Passive attenuator for shelter protection against explosions
KR100704215B1 (en) 2002-03-05 2007-04-10 오노 야꾸힝 고교 가부시키가이샤 8-azaprostaglandin derivative compounds and drugs containing the compounds as the active ingredient

Also Published As

Publication number Publication date
IT1061011B (en) 1982-10-20
FR2304340B1 (en) 1979-06-29
AT348163B (en) 1979-02-12
DK140937B (en) 1979-12-10
SE418290B (en) 1981-05-18
FI760744A (en) 1976-09-22
ES458389A1 (en) 1978-02-16
NZ180251A (en) 1978-07-28
CH611881A5 (en) 1979-06-29
ATA195676A (en) 1978-06-15
FI61692C (en) 1982-09-10
JPS51138671A (en) 1976-11-30
IE42966B1 (en) 1980-11-19
SE7603400L (en) 1976-09-22
DK140937C (en) 1980-05-19
FR2304340A1 (en) 1976-10-15
DE2612114A1 (en) 1976-10-07
NO144147C (en) 1981-07-15
CH611604A5 (en) 1979-06-15
OA05279A (en) 1981-02-28
DK88276A (en) 1976-09-22
AU1189976A (en) 1977-09-15
NO760994L (en) 1976-09-22
ZA761448B (en) 1977-03-30
FI61692B (en) 1982-05-31
NL7602891A (en) 1976-09-23
NO144147B (en) 1981-03-23
AU501105B2 (en) 1979-06-14
GB1529852A (en) 1978-10-25
YU73876A (en) 1982-10-31
JPS607602B2 (en) 1985-02-26
SU614746A3 (en) 1978-07-05
IE42966L (en) 1976-09-21
MX3301E (en) 1980-09-03
CA1076587A (en) 1980-04-29
BE839761A (en) 1976-09-20
PT64919B (en) 1977-08-24
AR213172A1 (en) 1978-12-29
HU173348B (en) 1979-04-28
PT64919A (en) 1976-04-01

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