ES405648A1 - Procedure for the preparation of new acids 4- (4 bifenilil) -4-hydroxy-butirrics, its esteres or lactonas. (Machine-translation by Google Translate, not legally binding) - Google Patents
Procedure for the preparation of new acids 4- (4 bifenilil) -4-hydroxy-butirrics, its esteres or lactonas. (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES405648A1 ES405648A1 ES405648A ES405648A ES405648A1 ES 405648 A1 ES405648 A1 ES 405648A1 ES 405648 A ES405648 A ES 405648A ES 405648 A ES405648 A ES 405648A ES 405648 A1 ES405648 A1 ES 405648A1
- Authority
- ES
- Spain
- Prior art keywords
- general formula
- hydrogen atom
- hydrogen
- carbon atoms
- translation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
- C07C205/56—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups bound to carbon atoms of six-membered aromatic rings and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
- C07C45/46—Friedel-Crafts reactions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
- C07C49/813—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen polycyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
- C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
- C07C59/56—Unsaturated compounds containing hydroxy or O-metal groups containing halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/76—Unsaturated compounds containing keto groups
- C07C59/88—Unsaturated compounds containing keto groups containing halogen
Abstract
Procedure for the preparation of new 4- (4-biphenyl) -4-hydroxy-butyric acids, their esters or lactones of the general formulas I and II **(See formula)** wherein R1 signifies a hydrogen or halogen atom, the cyano, nitro group, or an amino group optionally substituted by an acyl radical with 1 to 4 carbon atoms; R2 means a hydrogen atom, a halogen atom or an alcohol radical with 1 to 3 carbon atoms; R3 signifies a hydrogen or halogen atom; and R4 means a hydrogen atom or an alcohol group with 1 to carbon atoms, and in case R4 represents a hydrogen atom, of its physiologically compatible salts with organic or inorganic acids, characterized in that a 4-vinyl is reacted -biphenyl of the general formula III **(See formula)** with metallic acetates with an oxidizing effect in the presence of acetic acid, acetic anhydride and alkali metal acetates, and the compound obtained from formula Ia is split, if desired, by hydrolysis, to form a compound of general formula I; and a compound of the general formula I, in which it represents a hydrogen atom, is transformed, if desired, into a physiologically compatible salt by means of an organic or inorganic base and/or by means of usual methods in its esters of the general formula I, preferably through its acid halide. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19712112715 DE2112715A1 (en) | 1971-03-17 | 1971-03-17 | New 4- (4-biphenylyl) -4-hydroxybutyric acids, their salts, esters and lactones |
Publications (1)
Publication Number | Publication Date |
---|---|
ES405648A1 true ES405648A1 (en) | 1975-07-16 |
Family
ID=5801759
Family Applications (10)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES400790A Expired ES400790A1 (en) | 1971-03-17 | 1972-03-15 | Procedure for the preparation of new acids 4- (4-bifenilil) - 4 - hydroxibutirics, its esteres or lactonas. (Machine-translation by Google Translate, not legally binding) |
ES405651A Expired ES405651A1 (en) | 1971-03-17 | 1972-08-08 | Procedure for the preparation of new acids 4- (4 bifenilil) -4-hydroxy-butirrics, its esteres or lactonas. (Machine-translation by Google Translate, not legally binding) |
ES405647A Expired ES405647A1 (en) | 1971-03-17 | 1972-08-08 | Procedure for the preparation of new acids 4- (4 bifenilil) -44-hydroxy-butirrics, its esters or lactons. (Machine-translation by Google Translate, not legally binding) |
ES405650A Expired ES405650A1 (en) | 1971-03-17 | 1972-08-08 | Procedure for the preparation of new acids 4- (4 bifenilil) -4-hydroxy-butirrics, its esteres or lactonas. (Machine-translation by Google Translate, not legally binding) |
ES405644A Expired ES405644A1 (en) | 1971-03-17 | 1972-08-08 | Procedure for the preparation of new acids 4- (u bifenilil) -4-hydroxy-butirrics, its esteres or lactonas. (Machine-translation by Google Translate, not legally binding) |
ES405645A Expired ES405645A1 (en) | 1971-03-17 | 1972-08-08 | Procedure for the preparation of new acids 4- (4 bifenilil) -4-hydroxy-butirrics, its esteres or lactonas. (Machine-translation by Google Translate, not legally binding) |
ES405646A Expired ES405646A1 (en) | 1971-03-17 | 1972-08-08 | Procedure for the preparation of new acids 4- (4 bifenilil) -4-hydroxy-butirrics, its esteres or lactonas. (Machine-translation by Google Translate, not legally binding) |
ES405643A Expired ES405643A1 (en) | 1971-03-17 | 1972-08-08 | Procedure for the preparation of new acids 4- (4 bifenilil) -4-hydroxy-butirrics, its esteres or lactonas. (Machine-translation by Google Translate, not legally binding) |
ES405648A Expired ES405648A1 (en) | 1971-03-17 | 1972-08-08 | Procedure for the preparation of new acids 4- (4 bifenilil) -4-hydroxy-butirrics, its esteres or lactonas. (Machine-translation by Google Translate, not legally binding) |
ES405649A Expired ES405649A1 (en) | 1971-03-17 | 1972-08-08 | Procedure for the preparation of new acids 4- (4bifenilil) -4-hydroxy-butirrics, its esteres or lactonas. (Machine-translation by Google Translate, not legally binding) |
Family Applications Before (8)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES400790A Expired ES400790A1 (en) | 1971-03-17 | 1972-03-15 | Procedure for the preparation of new acids 4- (4-bifenilil) - 4 - hydroxibutirics, its esteres or lactonas. (Machine-translation by Google Translate, not legally binding) |
ES405651A Expired ES405651A1 (en) | 1971-03-17 | 1972-08-08 | Procedure for the preparation of new acids 4- (4 bifenilil) -4-hydroxy-butirrics, its esteres or lactonas. (Machine-translation by Google Translate, not legally binding) |
ES405647A Expired ES405647A1 (en) | 1971-03-17 | 1972-08-08 | Procedure for the preparation of new acids 4- (4 bifenilil) -44-hydroxy-butirrics, its esters or lactons. (Machine-translation by Google Translate, not legally binding) |
ES405650A Expired ES405650A1 (en) | 1971-03-17 | 1972-08-08 | Procedure for the preparation of new acids 4- (4 bifenilil) -4-hydroxy-butirrics, its esteres or lactonas. (Machine-translation by Google Translate, not legally binding) |
ES405644A Expired ES405644A1 (en) | 1971-03-17 | 1972-08-08 | Procedure for the preparation of new acids 4- (u bifenilil) -4-hydroxy-butirrics, its esteres or lactonas. (Machine-translation by Google Translate, not legally binding) |
ES405645A Expired ES405645A1 (en) | 1971-03-17 | 1972-08-08 | Procedure for the preparation of new acids 4- (4 bifenilil) -4-hydroxy-butirrics, its esteres or lactonas. (Machine-translation by Google Translate, not legally binding) |
ES405646A Expired ES405646A1 (en) | 1971-03-17 | 1972-08-08 | Procedure for the preparation of new acids 4- (4 bifenilil) -4-hydroxy-butirrics, its esteres or lactonas. (Machine-translation by Google Translate, not legally binding) |
ES405643A Expired ES405643A1 (en) | 1971-03-17 | 1972-08-08 | Procedure for the preparation of new acids 4- (4 bifenilil) -4-hydroxy-butirrics, its esteres or lactonas. (Machine-translation by Google Translate, not legally binding) |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES405649A Expired ES405649A1 (en) | 1971-03-17 | 1972-08-08 | Procedure for the preparation of new acids 4- (4bifenilil) -4-hydroxy-butirrics, its esteres or lactonas. (Machine-translation by Google Translate, not legally binding) |
Country Status (6)
Country | Link |
---|---|
AT (13) | AT317877B (en) |
CH (3) | CH586178A5 (en) |
DE (1) | DE2112715A1 (en) |
DK (1) | DK132943C (en) |
ES (10) | ES400790A1 (en) |
FR (1) | FR2279385A1 (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5973579A (en) * | 1982-10-19 | 1984-04-25 | Kotobuki Seiyaku Kk | Benzofuran or benzothiophene derivative, diuretic agent containing said compound as active constituent and preparation thereof |
US4777288A (en) * | 1987-06-11 | 1988-10-11 | Pfizer Inc. | Process for preparing a 4,4-diphenylbutanoic acid derivative |
AT401513B (en) * | 1994-12-22 | 1996-09-25 | Chemie Linz Gmbh | METHOD FOR PRODUCING 2-HYDROXY-4-PHENYLBUTTERIC ACID |
FR2817256B1 (en) | 2000-11-27 | 2005-07-15 | Univ Pasteur | DERIVATIVES OF 4-HYDROXYBUTANOIC ACID AND ITS SUPERIOR APPROACHES AS GAMMA-HYDROXYBUTYRATE (GHB) RECEPTOR LIGANDS, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME AND PHARMACEUTICAL USES |
AR044152A1 (en) | 2003-05-09 | 2005-08-24 | Bayer Corp | RENTAL DERIVATIVES, METHOD OF PREPARATION AND USE FOR THE TREATMENT OF OBESITY |
-
1971
- 1971-03-17 DE DE19712112715 patent/DE2112715A1/en active Pending
-
1972
- 1972-03-14 CH CH1083775A patent/CH586178A5/xx not_active IP Right Cessation
- 1972-03-14 CH CH1083875A patent/CH585173A5/xx not_active IP Right Cessation
- 1972-03-14 CH CH371572A patent/CH583679A5/xx not_active IP Right Cessation
- 1972-03-15 ES ES400790A patent/ES400790A1/en not_active Expired
- 1972-03-16 AT AT1873A patent/AT317877B/en active
- 1972-03-16 AT AT00014/73A patent/AT319219B/en not_active IP Right Cessation
- 1972-03-16 AT AT222172A patent/AT317188B/en not_active IP Right Cessation
- 1972-03-16 AT AT00025/73A patent/AT320622B/en not_active IP Right Cessation
- 1972-03-16 AT AT2373A patent/AT318586B/en active
- 1972-03-16 AT AT00022/73A patent/AT318585B/en not_active IP Right Cessation
- 1972-03-16 DK DK124272A patent/DK132943C/en active
- 1972-03-16 AT AT2073A patent/AT317878B/en active
- 1972-03-16 AT AT00016/73A patent/AT317876B/en not_active IP Right Cessation
- 1972-03-16 AT AT00021/73A patent/AT319221B/en not_active IP Right Cessation
- 1972-03-16 AT AT00019/73A patent/AT320620B/en not_active IP Right Cessation
- 1972-03-16 AT AT00017/73A patent/AT319220B/en not_active IP Right Cessation
- 1972-08-08 ES ES405651A patent/ES405651A1/en not_active Expired
- 1972-08-08 ES ES405647A patent/ES405647A1/en not_active Expired
- 1972-08-08 ES ES405650A patent/ES405650A1/en not_active Expired
- 1972-08-08 ES ES405644A patent/ES405644A1/en not_active Expired
- 1972-08-08 ES ES405645A patent/ES405645A1/en not_active Expired
- 1972-08-08 ES ES405646A patent/ES405646A1/en not_active Expired
- 1972-08-08 ES ES405643A patent/ES405643A1/en not_active Expired
- 1972-08-08 ES ES405648A patent/ES405648A1/en not_active Expired
- 1972-08-08 ES ES405649A patent/ES405649A1/en not_active Expired
-
1973
- 1973-01-02 AT AT1573A patent/AT317875B/en active
- 1973-01-02 AT AT00024/73A patent/AT320621B/en not_active IP Right Cessation
-
1974
- 1974-12-19 FR FR7442065A patent/FR2279385A1/en not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
AT320622B (en) | 1975-02-25 |
AT317877B (en) | 1974-09-25 |
AT317876B (en) | 1974-09-25 |
ES405643A1 (en) | 1975-07-16 |
CH586178A5 (en) | 1977-03-31 |
ES405649A1 (en) | 1975-07-16 |
AT317878B (en) | 1974-09-25 |
ES405645A1 (en) | 1975-07-16 |
AT320621B (en) | 1975-02-25 |
AT319220B (en) | 1974-12-10 |
ES405650A1 (en) | 1975-07-16 |
AT317188B (en) | 1974-08-12 |
CH585173A5 (en) | 1977-02-28 |
ES405646A1 (en) | 1975-07-16 |
ES405644A1 (en) | 1975-07-16 |
AT319221B (en) | 1974-12-10 |
ES400790A1 (en) | 1975-01-16 |
AT318586B (en) | 1974-10-25 |
AT318585B (en) | 1974-10-25 |
AT317875B (en) | 1974-09-25 |
DK132943B (en) | 1976-03-01 |
CH583679A5 (en) | 1977-01-14 |
AT319219B (en) | 1974-12-10 |
FR2279385A1 (en) | 1976-02-20 |
AT320620B (en) | 1975-02-25 |
ES405651A1 (en) | 1975-07-16 |
ES405647A1 (en) | 1975-07-16 |
DK132943C (en) | 1976-08-02 |
DE2112715A1 (en) | 1972-10-05 |
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