ES405647A1 - Procedure for the preparation of new acids 4- (4 bifenilil) -44-hydroxy-butirrics, its esters or lactons. (Machine-translation by Google Translate, not legally binding) - Google Patents

Procedure for the preparation of new acids 4- (4 bifenilil) -44-hydroxy-butirrics, its esters or lactons. (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES405647A1
ES405647A1 ES405647A ES405647A ES405647A1 ES 405647 A1 ES405647 A1 ES 405647A1 ES 405647 A ES405647 A ES 405647A ES 405647 A ES405647 A ES 405647A ES 405647 A1 ES405647 A1 ES 405647A1
Authority
ES
Spain
Prior art keywords
hydroxy
esters
general formula
hydrogen atom
translation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES405647A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH
Publication of ES405647A1 publication Critical patent/ES405647A1/en
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00Carboxylic acid nitriles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/56Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups bound to carbon atoms of six-membered aromatic rings and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46Friedel-Crafts reactions
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/80Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
    • C07C49/813Ketones containing a keto group bound to a six-membered aromatic ring containing halogen polycyclic
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/58Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40Unsaturated compounds
    • C07C59/42Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/56Unsaturated compounds containing hydroxy or O-metal groups containing halogen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40Unsaturated compounds
    • C07C59/76Unsaturated compounds containing keto groups
    • C07C59/88Unsaturated compounds containing keto groups containing halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)

Abstract

Procedure for the preparation of new 4- (4-biphenyl) -4-hydroxy-butyric acids, their esters or lactones of the general formulas I and II **(See formula)** wherein R1 signifies a hydrogen or halogen atom, the cyano, nitro group, or an amino group optionally substituted by an acyl radical with 1 to 4 carbon atoms; R2 means a hydrogen atom, a halogen atom or an alcohol radical with 1 to 3 carbon atoms; R3 signifies a hydrogen or halogen atom; and R4 means a hydrogen atom or an alcoholic group with 1 to 4 carbon atoms, and, if R4 represents a hydrogen atom, its physiologically compatible salts with organic or inorganic acids, characterized in that an amide of 4- (4-Biphenyl) -4-hydroxy-butyric acid of the general formula III **(See formula)** wherein R1 to R3 have the meanings set forth above and A stands for the radical of a substituted or unsubstituted amine a compound of the general formula I, wherein R4 represents a hydrogen atom, if desired in a physiologically compatible salt by by means of an organic or inorganic base, and/or by means of usual methods in its esters of the general formula I, preferably through its acid halide, or in lactones of the general formula II. (Machine-translation by Google Translate, not legally binding)
ES405647A 1971-03-17 1972-08-08 Procedure for the preparation of new acids 4- (4 bifenilil) -44-hydroxy-butirrics, its esters or lactons. (Machine-translation by Google Translate, not legally binding) Expired ES405647A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19712112715 DE2112715A1 (en) 1971-03-17 1971-03-17 New 4- (4-biphenylyl) -4-hydroxybutyric acids, their salts, esters and lactones

Publications (1)

Publication Number Publication Date
ES405647A1 true ES405647A1 (en) 1975-07-16

Family

ID=5801759

Family Applications (10)

Application Number Title Priority Date Filing Date
ES400790A Expired ES400790A1 (en) 1971-03-17 1972-03-15 Procedure for the preparation of new acids 4- (4-bifenilil) - 4 - hydroxibutirics, its esteres or lactonas. (Machine-translation by Google Translate, not legally binding)
ES405645A Expired ES405645A1 (en) 1971-03-17 1972-08-08 Procedure for the preparation of new acids 4- (4 bifenilil) -4-hydroxy-butirrics, its esteres or lactonas. (Machine-translation by Google Translate, not legally binding)
ES405647A Expired ES405647A1 (en) 1971-03-17 1972-08-08 Procedure for the preparation of new acids 4- (4 bifenilil) -44-hydroxy-butirrics, its esters or lactons. (Machine-translation by Google Translate, not legally binding)
ES405644A Expired ES405644A1 (en) 1971-03-17 1972-08-08 Procedure for the preparation of new acids 4- (u bifenilil) -4-hydroxy-butirrics, its esteres or lactonas. (Machine-translation by Google Translate, not legally binding)
ES405643A Expired ES405643A1 (en) 1971-03-17 1972-08-08 Procedure for the preparation of new acids 4- (4 bifenilil) -4-hydroxy-butirrics, its esteres or lactonas. (Machine-translation by Google Translate, not legally binding)
ES405651A Expired ES405651A1 (en) 1971-03-17 1972-08-08 Procedure for the preparation of new acids 4- (4 bifenilil) -4-hydroxy-butirrics, its esteres or lactonas. (Machine-translation by Google Translate, not legally binding)
ES405646A Expired ES405646A1 (en) 1971-03-17 1972-08-08 Procedure for the preparation of new acids 4- (4 bifenilil) -4-hydroxy-butirrics, its esteres or lactonas. (Machine-translation by Google Translate, not legally binding)
ES405648A Expired ES405648A1 (en) 1971-03-17 1972-08-08 Procedure for the preparation of new acids 4- (4 bifenilil) -4-hydroxy-butirrics, its esteres or lactonas. (Machine-translation by Google Translate, not legally binding)
ES405649A Expired ES405649A1 (en) 1971-03-17 1972-08-08 Procedure for the preparation of new acids 4- (4bifenilil) -4-hydroxy-butirrics, its esteres or lactonas. (Machine-translation by Google Translate, not legally binding)
ES405650A Expired ES405650A1 (en) 1971-03-17 1972-08-08 Procedure for the preparation of new acids 4- (4 bifenilil) -4-hydroxy-butirrics, its esteres or lactonas. (Machine-translation by Google Translate, not legally binding)

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES400790A Expired ES400790A1 (en) 1971-03-17 1972-03-15 Procedure for the preparation of new acids 4- (4-bifenilil) - 4 - hydroxibutirics, its esteres or lactonas. (Machine-translation by Google Translate, not legally binding)
ES405645A Expired ES405645A1 (en) 1971-03-17 1972-08-08 Procedure for the preparation of new acids 4- (4 bifenilil) -4-hydroxy-butirrics, its esteres or lactonas. (Machine-translation by Google Translate, not legally binding)

Family Applications After (7)

Application Number Title Priority Date Filing Date
ES405644A Expired ES405644A1 (en) 1971-03-17 1972-08-08 Procedure for the preparation of new acids 4- (u bifenilil) -4-hydroxy-butirrics, its esteres or lactonas. (Machine-translation by Google Translate, not legally binding)
ES405643A Expired ES405643A1 (en) 1971-03-17 1972-08-08 Procedure for the preparation of new acids 4- (4 bifenilil) -4-hydroxy-butirrics, its esteres or lactonas. (Machine-translation by Google Translate, not legally binding)
ES405651A Expired ES405651A1 (en) 1971-03-17 1972-08-08 Procedure for the preparation of new acids 4- (4 bifenilil) -4-hydroxy-butirrics, its esteres or lactonas. (Machine-translation by Google Translate, not legally binding)
ES405646A Expired ES405646A1 (en) 1971-03-17 1972-08-08 Procedure for the preparation of new acids 4- (4 bifenilil) -4-hydroxy-butirrics, its esteres or lactonas. (Machine-translation by Google Translate, not legally binding)
ES405648A Expired ES405648A1 (en) 1971-03-17 1972-08-08 Procedure for the preparation of new acids 4- (4 bifenilil) -4-hydroxy-butirrics, its esteres or lactonas. (Machine-translation by Google Translate, not legally binding)
ES405649A Expired ES405649A1 (en) 1971-03-17 1972-08-08 Procedure for the preparation of new acids 4- (4bifenilil) -4-hydroxy-butirrics, its esteres or lactonas. (Machine-translation by Google Translate, not legally binding)
ES405650A Expired ES405650A1 (en) 1971-03-17 1972-08-08 Procedure for the preparation of new acids 4- (4 bifenilil) -4-hydroxy-butirrics, its esteres or lactonas. (Machine-translation by Google Translate, not legally binding)

Country Status (6)

Country Link
AT (13) AT318585B (en)
CH (3) CH583679A5 (en)
DE (1) DE2112715A1 (en)
DK (1) DK132943C (en)
ES (10) ES400790A1 (en)
FR (1) FR2279385A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5973579A (en) * 1982-10-19 1984-04-25 Kotobuki Seiyaku Kk Benzofuran or benzothiophene derivative, diuretic agent containing said compound as active constituent and preparation thereof
US4777288A (en) * 1987-06-11 1988-10-11 Pfizer Inc. Process for preparing a 4,4-diphenylbutanoic acid derivative
AT401513B (en) * 1994-12-22 1996-09-25 Chemie Linz Gmbh METHOD FOR PRODUCING 2-HYDROXY-4-PHENYLBUTTERIC ACID
FR2817256B1 (en) 2000-11-27 2005-07-15 Univ Pasteur DERIVATIVES OF 4-HYDROXYBUTANOIC ACID AND ITS SUPERIOR APPROACHES AS GAMMA-HYDROXYBUTYRATE (GHB) RECEPTOR LIGANDS, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME AND PHARMACEUTICAL USES
AR044152A1 (en) 2003-05-09 2005-08-24 Bayer Corp RENTAL DERIVATIVES, METHOD OF PREPARATION AND USE FOR THE TREATMENT OF OBESITY

Also Published As

Publication number Publication date
DK132943B (en) 1976-03-01
DE2112715A1 (en) 1972-10-05
DK132943C (en) 1976-08-02
AT317877B (en) 1974-09-25
AT319220B (en) 1974-12-10
AT320622B (en) 1975-02-25
ES405650A1 (en) 1975-07-16
ES405646A1 (en) 1975-07-16
AT318586B (en) 1974-10-25
AT317876B (en) 1974-09-25
AT320620B (en) 1975-02-25
CH583679A5 (en) 1977-01-14
CH586178A5 (en) 1977-03-31
AT317878B (en) 1974-09-25
ES405649A1 (en) 1975-07-16
ES405645A1 (en) 1975-07-16
AT318585B (en) 1974-10-25
AT317188B (en) 1974-08-12
ES405648A1 (en) 1975-07-16
ES405644A1 (en) 1975-07-16
ES405651A1 (en) 1975-07-16
CH585173A5 (en) 1977-02-28
ES400790A1 (en) 1975-01-16
FR2279385A1 (en) 1976-02-20
ES405643A1 (en) 1975-07-16
AT320621B (en) 1975-02-25
AT319219B (en) 1974-12-10
AT319221B (en) 1974-12-10
AT317875B (en) 1974-09-25

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