FR2279385A1 - Biphenylyl-butyric acid derivs. - anti phlogistics - Google Patents

Biphenylyl-butyric acid derivs. - anti phlogistics

Info

Publication number
FR2279385A1
FR2279385A1 FR7442065A FR7442065A FR2279385A1 FR 2279385 A1 FR2279385 A1 FR 2279385A1 FR 7442065 A FR7442065 A FR 7442065A FR 7442065 A FR7442065 A FR 7442065A FR 2279385 A1 FR2279385 A1 FR 2279385A1
Authority
FR
France
Prior art keywords
phlogistics
biphenylyl
butyric acid
choh
hal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
FR7442065A
Other languages
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH
Publication of FR2279385A1 publication Critical patent/FR2279385A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/56—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups bound to carbon atoms of six-membered aromatic rings and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
    • C07C49/813—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/56—Unsaturated compounds containing hydroxy or O-metal groups containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/88—Unsaturated compounds containing keto groups containing halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)

Abstract

Title cpds. of formula (I): where A = CH2, CHOH or CO; R1 = H or hal, or (if R2 and R3 = H) ME; R3 = H) Me; R2 = H, hal, CN, NO2, NH2, or (1-4C) NH acyl; R3 = H or hal; R4 = (1-4C) alkyl; and at least one of R1-R3 = H, including salts, esters, and lactones of (I), are of use as anti-phlogistics. (I) are prepd. e.g., A = CO, by condensing a biphenyl with a succinic halide or anhydride and a Lewis acid; A = CH2 by reducing I (A = CO or CHOH) and other unsatd. analogues; A = CHOH by selective, partial redn. of I(A = CO).
FR7442065A 1971-03-17 1974-12-19 Biphenylyl-butyric acid derivs. - anti phlogistics Withdrawn FR2279385A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19712112715 DE2112715A1 (en) 1971-03-17 1971-03-17 New 4- (4-biphenylyl) -4-hydroxybutyric acids, their salts, esters and lactones

Publications (1)

Publication Number Publication Date
FR2279385A1 true FR2279385A1 (en) 1976-02-20

Family

ID=5801759

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7442065A Withdrawn FR2279385A1 (en) 1971-03-17 1974-12-19 Biphenylyl-butyric acid derivs. - anti phlogistics

Country Status (6)

Country Link
AT (13) AT318585B (en)
CH (3) CH583679A5 (en)
DE (1) DE2112715A1 (en)
DK (1) DK132943C (en)
ES (10) ES400790A1 (en)
FR (1) FR2279385A1 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2534582A1 (en) * 1982-10-19 1984-04-20 Kotobuki Seiyaku Co Ltd NOVEL BENZOFURAN AND BENZOTHIOPHENE DERIVATIVES, USEFUL AS ANTI-HYPERURICEMIA AND ANTI-HYPERTENSION AGENTS, AND PROCESS FOR THEIR MANUFACTURE
WO2002042250A1 (en) 2000-11-27 2002-05-30 Universite Louis Pasteur (Etablissement Public A Caractere Scientifique, Culturel Et Professionnel) DERIVATIVES OF 4-HYDROXYBUTANOIC ACID AND OF ITS HIGHER HOMOLOGUE AS LIGANDS OF η-HYDROXYBUTYRATE (GHB) RECEPTORS, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME AND PHARMACEUTICAL USES

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4777288A (en) * 1987-06-11 1988-10-11 Pfizer Inc. Process for preparing a 4,4-diphenylbutanoic acid derivative
AT401513B (en) * 1994-12-22 1996-09-25 Chemie Linz Gmbh METHOD FOR PRODUCING 2-HYDROXY-4-PHENYLBUTTERIC ACID
AR044152A1 (en) 2003-05-09 2005-08-24 Bayer Corp RENTAL DERIVATIVES, METHOD OF PREPARATION AND USE FOR THE TREATMENT OF OBESITY

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2534582A1 (en) * 1982-10-19 1984-04-20 Kotobuki Seiyaku Co Ltd NOVEL BENZOFURAN AND BENZOTHIOPHENE DERIVATIVES, USEFUL AS ANTI-HYPERURICEMIA AND ANTI-HYPERTENSION AGENTS, AND PROCESS FOR THEIR MANUFACTURE
WO2002042250A1 (en) 2000-11-27 2002-05-30 Universite Louis Pasteur (Etablissement Public A Caractere Scientifique, Culturel Et Professionnel) DERIVATIVES OF 4-HYDROXYBUTANOIC ACID AND OF ITS HIGHER HOMOLOGUE AS LIGANDS OF η-HYDROXYBUTYRATE (GHB) RECEPTORS, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME AND PHARMACEUTICAL USES
FR2817256A1 (en) * 2000-11-27 2002-05-31 Univ Pasteur DERIVATIVES OF 4-HYDROXYBUTANOIC ACID AND ITS SUPERIOR APPROACHES AS GAMMA-HYDROXYBUTYRATE (GHB) RECEPTOR LIGANDS, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME AND PHARMACEUTICAL USES

Also Published As

Publication number Publication date
CH585173A5 (en) 1977-02-28
DE2112715A1 (en) 1972-10-05
CH583679A5 (en) 1977-01-14
ES405646A1 (en) 1975-07-16
AT319221B (en) 1974-12-10
ES405650A1 (en) 1975-07-16
ES405647A1 (en) 1975-07-16
AT317876B (en) 1974-09-25
DK132943C (en) 1976-08-02
AT320621B (en) 1975-02-25
AT320620B (en) 1975-02-25
AT317877B (en) 1974-09-25
AT318585B (en) 1974-10-25
ES405644A1 (en) 1975-07-16
AT317188B (en) 1974-08-12
ES405643A1 (en) 1975-07-16
ES400790A1 (en) 1975-01-16
ES405649A1 (en) 1975-07-16
DK132943B (en) 1976-03-01
ES405648A1 (en) 1975-07-16
AT319219B (en) 1974-12-10
AT317875B (en) 1974-09-25
AT320622B (en) 1975-02-25
CH586178A5 (en) 1977-03-31
ES405645A1 (en) 1975-07-16
AT319220B (en) 1974-12-10
ES405651A1 (en) 1975-07-16
AT318586B (en) 1974-10-25
AT317878B (en) 1974-09-25

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Legal Events

Date Code Title Description
ST Notification of lapse