ES426948A1 - Procedure for the preparation of new 1,4-benzodiazepinas. (Machine-translation by Google Translate, not legally binding) - Google Patents

Procedure for the preparation of new 1,4-benzodiazepinas. (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES426948A1
ES426948A1 ES426948A ES426948A ES426948A1 ES 426948 A1 ES426948 A1 ES 426948A1 ES 426948 A ES426948 A ES 426948A ES 426948 A ES426948 A ES 426948A ES 426948 A1 ES426948 A1 ES 426948A1
Authority
ES
Spain
Prior art keywords
organic
physiologically compatible
procedure
signifies
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES426948A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH
Publication of ES426948A1 publication Critical patent/ES426948A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/12—1,5-Benzodiazepines; Hydrogenated 1,5-benzodiazepines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Abstract

Procedure for the preparation of new 1,4-benzodiazepines of the general formula I **(See formula)** wherein R1 signifies a halogen atom or a nitro group; R2 signifies a lower alcohol radical possibly substituted by halogen atoms or a dialcoylaminoalcohilo group; R3 represents a hydrogen or halogen atom; and R4 signifies a hydrogen atom, an aliphatic acyl radical optionally substituted with a carboxy or carbalkoxy group or an aromatic acyl radical optionally substituted with halogen atoms, as well as its acid addition salts physiologically compatible with organic and inorganic acids or its physiologically compatible salts with organic and inorganic bases, if R4 represents an aliphatic acyl radical substituted with a carboxy radical, characterized in that a compound of the general formula II is reduced, **(See formula)** wherein R1, R2 and R3 are as initially defined and R5 represents a hydrogen or alkali metal atom; and a compound obtained according to the procedure of the general formula i, in which R4 represents a hydrogen atom, is acylated if desired subsequently and/or is transformed into a salt by addition of acid physiologically compatible with an organic or inorganic acid, or it is transformed into a physiologically compatible salt with the organic or inorganic base, in case R4 represents an aliphatic acyl radical substituted with a carboxy radical. (Machine-translation by Google Translate, not legally binding)
ES426948A 1973-03-09 1974-06-04 Procedure for the preparation of new 1,4-benzodiazepinas. (Machine-translation by Google Translate, not legally binding) Expired ES426948A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2311714A DE2311714A1 (en) 1973-03-09 1973-03-09 NEW 1,4-BENZODIAZEPINE

Publications (1)

Publication Number Publication Date
ES426948A1 true ES426948A1 (en) 1976-07-16

Family

ID=5874264

Family Applications (3)

Application Number Title Priority Date Filing Date
ES423226A Expired ES423226A1 (en) 1973-03-09 1974-02-14 Procedure for the preparation of new 1,4-benzodiazepinas. (Machine-translation by Google Translate, not legally binding)
ES426949A Expired ES426949A1 (en) 1973-03-09 1974-06-04 Procedure for the preparation of new 1,4-benzodiazepinas. (Machine-translation by Google Translate, not legally binding)
ES426948A Expired ES426948A1 (en) 1973-03-09 1974-06-04 Procedure for the preparation of new 1,4-benzodiazepinas. (Machine-translation by Google Translate, not legally binding)

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES423226A Expired ES423226A1 (en) 1973-03-09 1974-02-14 Procedure for the preparation of new 1,4-benzodiazepinas. (Machine-translation by Google Translate, not legally binding)
ES426949A Expired ES426949A1 (en) 1973-03-09 1974-06-04 Procedure for the preparation of new 1,4-benzodiazepinas. (Machine-translation by Google Translate, not legally binding)

Country Status (13)

Country Link
JP (1) JPS49125383A (en)
AT (1) AT347860B (en)
AU (1) AU6641674A (en)
BE (1) BE812087A (en)
DD (1) DD112264A5 (en)
DE (1) DE2311714A1 (en)
ES (3) ES423226A1 (en)
FR (1) FR2220269A1 (en)
HU (1) HU166787B (en)
IL (1) IL44366A0 (en)
NL (1) NL7401546A (en)
RO (1) RO63578A (en)
SE (1) SE7403160L (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4820834A (en) * 1984-06-26 1989-04-11 Merck & Co., Inc. Benzodiazepine analogs
CA1332410C (en) * 1984-06-26 1994-10-11 Roger M. Freidinger Benzodiazepine analogs

Also Published As

Publication number Publication date
AT347860B (en) 1979-01-25
DE2311714A1 (en) 1974-09-19
NL7401546A (en) 1974-09-11
IL44366A0 (en) 1974-06-30
ATA112574A (en) 1978-05-15
ES426949A1 (en) 1976-07-16
AU6641674A (en) 1975-09-11
ES423226A1 (en) 1976-05-01
SE7403160L (en) 1974-09-10
BE812087A (en) 1974-09-09
FR2220269A1 (en) 1974-10-04
DD112264A5 (en) 1975-04-05
JPS49125383A (en) 1974-11-30
HU166787B (en) 1975-05-28
RO63578A (en) 1978-08-15

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