ES421098A1 - Fluoro-substituted thiaxanthene derivatives - Google Patents
Fluoro-substituted thiaxanthene derivativesInfo
- Publication number
- ES421098A1 ES421098A1 ES421098A ES421098A ES421098A1 ES 421098 A1 ES421098 A1 ES 421098A1 ES 421098 A ES421098 A ES 421098A ES 421098 A ES421098 A ES 421098A ES 421098 A1 ES421098 A1 ES 421098A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- see formula
- compound
- see
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D337/00—Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
- C07D337/02—Seven-membered rings
- C07D337/06—Seven-membered rings condensed with carbocyclic rings or ring systems
- C07D337/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
- C07D337/14—[b,f]-condensed
Abstract
A method for the preparation of fluorine-substituted thiaxanthenes of the formula **(See formula)** where X is (see formula) or (see formula) and Y (see formula) or (see formula), where Ac is an acyl radical or an aliphatic carboxylic acid having from one to 17 carbon atoms, inclusive, and their acid addition salts, characterized in that it comprises reacting a compound of the formula: **(See formula)** where X is as previously defined, with an amine of the formula **(See formula)** where Y is as previously defined, at elevated temperatures to obtain a compound of formula I, and isolating the compound of formula I as the free base or its non-toxic acid addition salt, and if desired, esterifying any group hydroxy present with a reactive derivative of an aliphatic carboxylic acid having 1 to 17 carbon atoms inclusive, and if desired, separating its individual isomers in a conventional manner. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB5691072A GB1453828A (en) | 1972-12-08 | 1972-12-08 | Fluoro-substituted thiaxanthene derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
ES421098A1 true ES421098A1 (en) | 1976-08-01 |
Family
ID=10477876
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES421098A Expired ES421098A1 (en) | 1972-12-08 | 1973-12-03 | Fluoro-substituted thiaxanthene derivatives |
ES444294A Expired ES444294A1 (en) | 1972-12-08 | 1976-01-14 | Fluoro-substituted thiaxanthene derivatives |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES444294A Expired ES444294A1 (en) | 1972-12-08 | 1976-01-14 | Fluoro-substituted thiaxanthene derivatives |
Country Status (19)
Country | Link |
---|---|
JP (1) | JPS594436B2 (en) |
AR (2) | AR202805A1 (en) |
AT (1) | AT332395B (en) |
BE (1) | BE808347A (en) |
CH (2) | CH590272A5 (en) |
CS (1) | CS176259B2 (en) |
DE (1) | DE2359359C3 (en) |
DK (1) | DK145576C (en) |
ES (2) | ES421098A1 (en) |
FI (1) | FI57410C (en) |
FR (1) | FR2209573B1 (en) |
GB (1) | GB1453828A (en) |
HU (1) | HU167778B (en) |
IE (1) | IE38554B1 (en) |
NL (1) | NL7316035A (en) |
NO (1) | NO138806C (en) |
PL (1) | PL95266B1 (en) |
SE (1) | SE400287B (en) |
ZA (1) | ZA738990B (en) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ189108A (en) * | 1977-12-29 | 1982-02-23 | Kefalas As | 2-methylthio-6-fluoro-9-(1-methyl-4-piperidylidene)-thioxanthene and pharmaceutical compositions intermediate 2-methylthio-6-fluoro-9-(1-methyl-4-piperidyl)-thioxanthen-9-ol |
US5173489A (en) * | 1986-04-10 | 1992-12-22 | The Dupont Merck Pharmaceutical Co. | α,α-disubstituted aromatics and heteroaromatics as cognition enhancers |
GB8628903D0 (en) * | 1986-12-03 | 1987-01-07 | Lunbeck A S H | Neuroleptic compounds |
US6395752B1 (en) * | 1999-03-04 | 2002-05-28 | Pharmaquest Limited | Method of treating depression using 1-threo-methylphenidate |
US6127385A (en) * | 1999-03-04 | 2000-10-03 | Pharmaquest Limited | Method of treating depression using l-threo-methylphenidate |
MX2009007235A (en) * | 2007-01-05 | 2009-10-16 | Bkg Pharma Aps | Low-carbohydrate milk with original calcium. |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE585338A (en) * | 1958-12-04 | |||
FR1463787A (en) * | 1963-10-14 | 1966-07-22 | Pfizer & Co C | Aminoalkyl-trisubstituted phosphonium compounds, derivatives of such compounds, and processes for their preparation |
-
1972
- 1972-12-08 GB GB5691072A patent/GB1453828A/en not_active Expired
-
1973
- 1973-11-23 CH CH1652873A patent/CH590272A5/xx not_active IP Right Cessation
- 1973-11-23 FI FI3618/73A patent/FI57410C/en active
- 1973-11-23 NL NL7316035A patent/NL7316035A/xx not_active Application Discontinuation
- 1973-11-23 CH CH1585676A patent/CH592085A5/xx not_active IP Right Cessation
- 1973-11-26 ZA ZA738990A patent/ZA738990B/en unknown
- 1973-11-28 DE DE2359359A patent/DE2359359C3/en not_active Expired
- 1973-11-29 AT AT1000373A patent/AT332395B/en not_active IP Right Cessation
- 1973-11-29 IE IE2161/73A patent/IE38554B1/en unknown
- 1973-12-03 ES ES421098A patent/ES421098A1/en not_active Expired
- 1973-12-06 CS CS8429A patent/CS176259B2/cs unknown
- 1973-12-07 BE BE138618A patent/BE808347A/en not_active IP Right Cessation
- 1973-12-07 NO NO4693/73A patent/NO138806C/en unknown
- 1973-12-07 SE SE7316567A patent/SE400287B/en unknown
- 1973-12-07 PL PL1973178366A patent/PL95266B1/en unknown
- 1973-12-07 FR FR7343766A patent/FR2209573B1/fr not_active Expired
- 1973-12-07 JP JP48136256A patent/JPS594436B2/en not_active Expired
- 1973-12-07 AR AR251406A patent/AR202805A1/en active
- 1973-12-07 HU HUKE936A patent/HU167778B/hu unknown
- 1973-12-10 DK DK667273A patent/DK145576C/en active
-
1974
- 1974-11-19 AR AR256579A patent/AR202672A1/en active
-
1976
- 1976-01-14 ES ES444294A patent/ES444294A1/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
IE38554B1 (en) | 1978-04-12 |
JPS4994691A (en) | 1974-09-09 |
FR2209573A1 (en) | 1974-07-05 |
SE400287B (en) | 1978-03-20 |
DK145576B (en) | 1982-12-13 |
DE2359359C3 (en) | 1978-11-02 |
DK145576C (en) | 1983-06-13 |
AR202672A1 (en) | 1975-06-30 |
CH590272A5 (en) | 1977-07-29 |
GB1453828A (en) | 1976-10-27 |
NL7316035A (en) | 1974-06-11 |
DE2359359B2 (en) | 1978-02-16 |
AT332395B (en) | 1976-09-27 |
ES444294A1 (en) | 1977-10-01 |
FI57410B (en) | 1980-04-30 |
FR2209573B1 (en) | 1977-12-09 |
NO138806C (en) | 1978-11-15 |
FI57410C (en) | 1980-08-11 |
BE808347A (en) | 1974-03-29 |
IE38554L (en) | 1974-06-08 |
NO138806B (en) | 1978-08-07 |
ZA738990B (en) | 1974-11-27 |
DE2359359A1 (en) | 1974-06-27 |
AR202805A1 (en) | 1975-07-24 |
PL95266B1 (en) | 1977-10-31 |
CH592085A5 (en) | 1977-10-14 |
HU167778B (en) | 1975-12-25 |
CS176259B2 (en) | 1977-06-30 |
JPS594436B2 (en) | 1984-01-30 |
ATA1000373A (en) | 1976-01-15 |
AU6296673A (en) | 1975-05-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19850211 |