ES412585A1 - Procedure for the preparation of derivatives of (alcoxy-4-alcohil-4-piperidinoalcohil) -10-phenotyazines. (Machine-translation by Google Translate, not legally binding) - Google Patents

Procedure for the preparation of derivatives of (alcoxy-4-alcohil-4-piperidinoalcohil) -10-phenotyazines. (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES412585A1
ES412585A1 ES412585A ES412585A ES412585A1 ES 412585 A1 ES412585 A1 ES 412585A1 ES 412585 A ES412585 A ES 412585A ES 412585 A ES412585 A ES 412585A ES 412585 A1 ES412585 A1 ES 412585A1
Authority
ES
Spain
Prior art keywords
formula
radical
reacted
alcohol
mineral
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES412585A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Publication of ES412585A1 publication Critical patent/ES412585A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/48—Oxygen atoms attached in position 4 having an acyclic carbon atom attached in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Preparation process of derivatives of (alkoxy-4-alcohol-4-piperidino-alcoholic) -10-phenothiazines and their addition salts with mineral or organic acids, said derivatives responding to formula 1: **(See formula)** in which X represents a hydrogen or chlorine atom or a trifluoromethyl, methoxy or methylthio radical, B and R, identical or different, represent a hydrogen atom or an alcohol radical comprising at most 4 carbon atoms, Z represents a linear or branched alcohol radical containing a maximum of 10 carbon atoms, p represents values 0 or 1, n represents values 0, 1 or 2, and A represents a hydrogen atom or a -COR1 radical, in which R1 represents a polymethoxy-phenyl radical or an alcohol radical containing a maximum of 18 carbon atoms and which may contain a double bond or an oxy (-O-) radical, or A represents a -COOR2 radical in which R2 represents a linear alcohol radical containing a maximum of 15 carbon atoms, a procedure characterized in that a halogen-alcohol-10-phenothiazine of formula 2 is reacted: **(See formula)** in which X, B and p have the aforementioned meanings and Y represents a chlorine or bromine atom, with a piperidine derivative of formula 3: **(See formula)** in which A, Z, R and n have the meanings indicated above, and either the product of formula 1 obtained is isolated and reacted, if desired, with a mineral or organic acid to form the salt thereof, or when A represents a hydrogen atom, said product is reacted, either with an acid chloride of formula Cl-CO-R1, in which R1 has the aforementioned meaning and the resulting product of formula 1 is isolated in which A represents a radical -COR1 that is reacted, if desired, with a mineral or organic acid to form the salt thereof, either with an alcoholic chloroformate of the formula Cl-COOR2 in which R2 has the previously indicated meaning and is isolated the resulting product of formula 1 in which A represents a radical -COOR2, which is reacted, if desired, with a mineral or organic acid to form the salt thereof. (Machine-translation by Google Translate, not legally binding)
ES412585A 1972-03-14 1973-03-13 Procedure for the preparation of derivatives of (alcoxy-4-alcohil-4-piperidinoalcohil) -10-phenotyazines. (Machine-translation by Google Translate, not legally binding) Expired ES412585A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7208802A FR2175565A1 (en) 1972-03-14 1972-03-14 10-(4-alkoxy-4-alkylpiperidinoalkyl)phenothiazines - - with neuroleptic,antihistaminic,analgesic and spasmolytic activity

Publications (1)

Publication Number Publication Date
ES412585A1 true ES412585A1 (en) 1976-01-16

Family

ID=9095160

Family Applications (1)

Application Number Title Priority Date Filing Date
ES412585A Expired ES412585A1 (en) 1972-03-14 1973-03-13 Procedure for the preparation of derivatives of (alcoxy-4-alcohil-4-piperidinoalcohil) -10-phenotyazines. (Machine-translation by Google Translate, not legally binding)

Country Status (2)

Country Link
ES (1) ES412585A1 (en)
FR (1) FR2175565A1 (en)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1344593A (en) * 1961-11-25 1963-11-29 Boehringer & Soehne Gmbh Process for the preparation of novel alkoxy-piperidine derivatives and their salts
FR1578731A (en) * 1967-11-24 1969-08-22

Also Published As

Publication number Publication date
FR2175565A1 (en) 1973-10-26
FR2175565B1 (en) 1975-03-14

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