ES421792A1 - Procedure for preparation of derivatives of tieno-benzazepinas. (Machine-translation by Google Translate, not legally binding) - Google Patents

Procedure for preparation of derivatives of tieno-benzazepinas. (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES421792A1
ES421792A1 ES421792A ES421792A ES421792A1 ES 421792 A1 ES421792 A1 ES 421792A1 ES 421792 A ES421792 A ES 421792A ES 421792 A ES421792 A ES 421792A ES 421792 A1 ES421792 A1 ES 421792A1
Authority
ES
Spain
Prior art keywords
formula
product
hal
derivatives
hydrogen atom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES421792A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Publication of ES421792A1 publication Critical patent/ES421792A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

A method of preparing thienobenzazepine derivatives of formula I: **(See formula)** where X and Y each represent a hydrogen atom, or X forms a carbon-carbon double bond with Y, R represents a hydrogen atom or a halogen atom, A represents an alcoholic radical comprising 1 to 4 carbon atoms, which may carry alkylated substituents, R1 and R2, identical or different, represent a hydrogen atom, an alcohol radical comprising 1 to 5 carbon atoms or a lower aralcohyl radical, as well as addition salts of said derivatives with mineral or organic acids, characterized in that a product of formula II is reacted **(See formula)** in which R, X and Y have the meaning already indicated, with a halogenated derivative of an acyl halide of formula: Hal-CO-A-Hal in which Hal represents a chlorine, bromine or iodine atom, and A has the meaning already indicated, to obtain a product of formula **(See formula)** where X, Y, A, R and Hal have the meaning already indicated; the said product of formula IV is subjected to the action of an amine of formula **(See formula)** in which R1 and R2 have the aforementioned meaning, to obtain the product of formula I in which X, Y, A, R, R1 and R2 have the aforementioned meanings, and because the reaction is made, if desired, by the product mentioned, with a mineral or organic acid to form the salt. (Machine-translation by Google Translate, not legally binding)
ES421792A 1972-12-27 1973-12-26 Procedure for preparation of derivatives of tieno-benzazepinas. (Machine-translation by Google Translate, not legally binding) Expired ES421792A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7246325A FR2211224A1 (en) 1972-12-27 1972-12-27 @-aminoalkanoyl thieno (3,2-B) (f)benzazepines - with antidepressant activity

Publications (1)

Publication Number Publication Date
ES421792A1 true ES421792A1 (en) 1976-04-01

Family

ID=9109326

Family Applications (1)

Application Number Title Priority Date Filing Date
ES421792A Expired ES421792A1 (en) 1972-12-27 1973-12-26 Procedure for preparation of derivatives of tieno-benzazepinas. (Machine-translation by Google Translate, not legally binding)

Country Status (7)

Country Link
JP (1) JPS504099A (en)
AT (1) AT329571B (en)
CA (1) CA1008854A (en)
CH (1) CH585754A5 (en)
DE (1) DE2364793A1 (en)
ES (1) ES421792A1 (en)
FR (1) FR2211224A1 (en)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2128030A1 (en) * 1971-03-01 1972-10-20 Roussel Uclaf 4-(alkylaminoalkyl) (4h) thieno (3,2-b) (f) benzazepines

Also Published As

Publication number Publication date
CH585754A5 (en) 1977-03-15
AT329571B (en) 1976-05-25
FR2211224A1 (en) 1974-07-19
DE2364793A1 (en) 1974-07-04
ATA1081773A (en) 1975-08-15
FR2211224B1 (en) 1976-04-23
JPS504099A (en) 1975-01-16
CA1008854A (en) 1977-04-19

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