FR2357563A1 - NEW 7H-PYRROLO (3,2-F) QUINAZOLINE-1,3-DIAMINES SUBSTITUTED IN POSITION 7, THEIR PROCESS FOR PREPARATION AND THE MEDICINAL PRODUCT CONTAINING THEM - Google Patents

NEW 7H-PYRROLO (3,2-F) QUINAZOLINE-1,3-DIAMINES SUBSTITUTED IN POSITION 7, THEIR PROCESS FOR PREPARATION AND THE MEDICINAL PRODUCT CONTAINING THEM

Info

Publication number
FR2357563A1
FR2357563A1 FR7721232A FR7721232A FR2357563A1 FR 2357563 A1 FR2357563 A1 FR 2357563A1 FR 7721232 A FR7721232 A FR 7721232A FR 7721232 A FR7721232 A FR 7721232A FR 2357563 A1 FR2357563 A1 FR 2357563A1
Authority
FR
France
Prior art keywords
quinazoline
pyrrolo
preparation
new
product containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7721232A
Other languages
French (fr)
Other versions
FR2357563B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Original Assignee
American Home Products Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Products Corp filed Critical American Home Products Corp
Publication of FR2357563A1 publication Critical patent/FR2357563A1/en
Application granted granted Critical
Publication of FR2357563B1 publication Critical patent/FR2357563B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Abstract

Novel 7-substituted 7H-pyrrolo[3,2-f]quinazoline-1,3-diamines of the formula in which the substituents are defined in claim 1, are prepared. These compounds are obtained by introducing the substituent Y into a corresponding compound of the formula I in which there is a hydrogen instead of Y. The first reaction is with an alkali metal base to give the corresponding alkali metal salt. The resulting salt is then reacted with a compound which provides the radical Y. The novel compounds can be used for preventing the growth of bacteria.
FR7721232A 1976-07-09 1977-07-08 NEW 7H-PYRROLO (3,2-F) QUINAZOLINE-1,3-DIAMINES SUBSTITUTED IN POSITION 7, THEIR PROCESS FOR PREPARATION AND THE MEDICINAL PRODUCT CONTAINING THEM Granted FR2357563A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US70400176A 1976-07-09 1976-07-09
US70400276A 1976-07-09 1976-07-09
GB5382176 1976-12-23
US78498777A 1977-04-06 1977-04-06

Publications (2)

Publication Number Publication Date
FR2357563A1 true FR2357563A1 (en) 1978-02-03
FR2357563B1 FR2357563B1 (en) 1983-03-11

Family

ID=27449036

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7721232A Granted FR2357563A1 (en) 1976-07-09 1977-07-08 NEW 7H-PYRROLO (3,2-F) QUINAZOLINE-1,3-DIAMINES SUBSTITUTED IN POSITION 7, THEIR PROCESS FOR PREPARATION AND THE MEDICINAL PRODUCT CONTAINING THEM

Country Status (13)

Country Link
JP (1) JPS539796A (en)
AU (1) AU507828B2 (en)
BE (1) BE856647A (en)
CA (1) CA1093555A (en)
CH (1) CH634069A5 (en)
DE (1) DE2731039A1 (en)
DK (1) DK309977A (en)
FR (1) FR2357563A1 (en)
IE (1) IE45427B1 (en)
IN (1) IN147488B (en)
MX (1) MX5133E (en)
NL (1) NL7707658A (en)
PH (1) PH13539A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0639075A4 (en) * 1990-11-14 1993-09-29 Chiron Corp Specific inhibition of dihydrofolate reductase and compounds therefor.

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100810468B1 (en) * 2001-10-10 2008-03-07 씨제이제일제당 (주) 1H-indole derivatives as a highly selective cyclooxygenase-2 inhibitor
US7262297B2 (en) * 2003-05-15 2007-08-28 Hoffmann-La Roche Inc. Diaminopyrroloquinazolines compounds as protein tyrosine phosphatase inhibitors

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0639075A4 (en) * 1990-11-14 1993-09-29 Chiron Corp Specific inhibition of dihydrofolate reductase and compounds therefor.
EP0639075A1 (en) * 1990-11-14 1995-02-22 Chiron Corporation Specific inhibition of dihydrofolate reductase and compounds therefor

Also Published As

Publication number Publication date
PH13539A (en) 1980-06-26
CA1093555A (en) 1981-01-13
JPS6254111B2 (en) 1987-11-13
DK309977A (en) 1978-01-10
FR2357563B1 (en) 1983-03-11
NL7707658A (en) 1978-01-11
AU507828B2 (en) 1980-02-28
DE2731039A1 (en) 1978-01-19
IE45427B1 (en) 1982-08-25
JPS539796A (en) 1978-01-28
IE45427L (en) 1978-10-06
IN147488B (en) 1980-03-15
BE856647A (en) 1978-01-09
AU2668777A (en) 1979-01-04
MX5133E (en) 1983-03-28
CH634069A5 (en) 1983-01-14

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Legal Events

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