EP0639075A4 - Specific inhibition of dihydrofolate reductase and compounds therefor. - Google Patents

Specific inhibition of dihydrofolate reductase and compounds therefor.

Info

Publication number
EP0639075A4
EP0639075A4 EP19920900837 EP92900837A EP0639075A4 EP 0639075 A4 EP0639075 A4 EP 0639075A4 EP 19920900837 EP19920900837 EP 19920900837 EP 92900837 A EP92900837 A EP 92900837A EP 0639075 A4 EP0639075 A4 EP 0639075A4
Authority
EP
European Patent Office
Prior art keywords
dihydrofolate reductase
specific inhibition
compounds therefor
therefor
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP19920900837
Other languages
German (de)
French (fr)
Other versions
EP0639075A1 (en
Inventor
Ivan Kompis
Jeffrey M Blaney
Charles K Marlow
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis Vaccines and Diagnostics Inc
Original Assignee
Chiron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiron Corp filed Critical Chiron Corp
Publication of EP0639075A4 publication Critical patent/EP0639075A4/en
Publication of EP0639075A1 publication Critical patent/EP0639075A1/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
EP92900837A 1990-11-14 1991-11-14 Specific inhibition of dihydrofolate reductase and compounds therefor Ceased EP0639075A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US61361990A 1990-11-14 1990-11-14
US613619 1990-11-14
US73069191A 1991-07-16 1991-07-16
US730691 1991-07-16
PCT/US1991/008515 WO1992008461A1 (en) 1990-11-14 1991-11-14 Specific inhibition of dihydrofolate reductase and compounds therefor

Publications (2)

Publication Number Publication Date
EP0639075A4 true EP0639075A4 (en) 1993-09-29
EP0639075A1 EP0639075A1 (en) 1995-02-22

Family

ID=27087063

Family Applications (1)

Application Number Title Priority Date Filing Date
EP92900837A Ceased EP0639075A1 (en) 1990-11-14 1991-11-14 Specific inhibition of dihydrofolate reductase and compounds therefor

Country Status (7)

Country Link
EP (1) EP0639075A1 (en)
JP (1) JPH07509215A (en)
AU (1) AU657348B2 (en)
CA (1) CA2095518A1 (en)
IE (1) IE913974A1 (en)
PT (1) PT99514B (en)
WO (1) WO1992008461A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5721242A (en) * 1993-06-17 1998-02-24 Hoffmann-La Roche Inc. Antibiotic combination
CN1136198C (en) * 1994-11-24 2004-01-28 巴斯利尔药物股份公司 Novel benzyl pyrimidines
TW438796B (en) * 1996-05-15 2001-06-07 Hoffmann La Roche 2,4-diaminopyrimidine derivatives, the manufacture process thereof, and the antibiotically-active pharmaceutical composition containing the same
WO1998037898A1 (en) * 1997-02-24 1998-09-03 Barclay Barry J Synergistically acting anti-fungal agents that are inhibitors of folate metabolism, especially methotrexate and sulfamethoxazole
RU2222347C2 (en) * 1999-05-24 2004-01-27 Санкио Компани Лимитед Anti-fas-antibody-containing pharmaceutical compositions
US8853228B2 (en) * 2007-06-04 2014-10-07 University Of Connecticut Heterocyclic analogs of propargyl-linked inhibitors of dihydrofolate reductase

Citations (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2658897A (en) * 1951-06-27 1953-11-10 Burroughs Wellcome Co 2, 4-diamino-5-benzyl pyrimidines
FR1090394A (en) * 1953-03-11 1955-03-30 Wellcome Found Pyrimidine derivatives and their manufacture
FR1292920A (en) * 1959-04-18 1962-05-11 Wellcome Found Pyrimidine derivatives and their preparation
US3671564A (en) * 1965-10-28 1972-06-20 Burroughs Wellcome Co Benzylidene cyano-acetals
DE1720031A1 (en) * 1966-02-19 1972-08-03 Wellcome Found Biologically active 5-benzylpyrimidine derivatives and processes for their preparation
US4024145A (en) * 1973-11-08 1977-05-17 Hoffmann-La Roche Inc. Benzylpyrimidine derivatives
DE2617967A1 (en) * 1976-04-24 1977-11-03 Nordmark Werke Gmbh PROCESS FOR THE PREPARATION OF 2,4-DIAMINO-5-BENZYLPYRIMIDINES
FR2357563A1 (en) * 1976-07-09 1978-02-03 American Home Prod NEW 7H-PYRROLO (3,2-F) QUINAZOLINE-1,3-DIAMINES SUBSTITUTED IN POSITION 7, THEIR PROCESS FOR PREPARATION AND THE MEDICINAL PRODUCT CONTAINING THEM
LU77269A1 (en) * 1977-05-05 1979-01-18
LU77268A1 (en) * 1977-05-05 1979-01-18
EP0003212A1 (en) * 1977-11-10 1979-08-08 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft 2.4-Diamino-5-benzylpyrimidines, pharmaceutical compositions containing them and their preparation
US4233445A (en) * 1979-07-05 1980-11-11 American Home Products Corporation 7-(Substituted)-7H-pyrrolo[3.2-F]-quinazoline-1,3-diamines
US4258045A (en) * 1979-11-30 1981-03-24 Merck & Co., Inc. Inhibitor of dihydrofolate reductase
EP0054756A2 (en) * 1980-11-27 1982-06-30 The Wellcome Foundation Limited Antibacterial benzylpyrimidines
US4451466A (en) * 1982-07-02 1984-05-29 Shell Oil Company Use of pyrroloquinazolinediamines as pesticides
EP0122580A1 (en) * 1983-04-14 1984-10-24 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Pyrimidine derivatives, their preparation and pharmaceutical compositions

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2852450A (en) * 1954-06-10 1958-09-16 Donnelley & Sons Co Method of copper plating
GB1181657A (en) * 1966-03-31 1970-02-18 Ici Ltd Pyrimidine Derivatives and Compositions Containing them
BE793253A (en) * 1971-12-23 1973-04-16 Lepetit Spa NEW BACTERICIDE COMPOSITIONS AND THEIR USE
OA07362A (en) * 1980-10-27 1984-06-30 May & Baker Ltd Pyrimidine derivatives, process for their preparation and compositions containing them.
EP0139613A1 (en) * 1983-08-29 1985-05-02 Ciba-Geigy Ag N-(2-nitrophenyl)-4-aminopyrimidine derivatives, their preparation and use
US4501890A (en) * 1983-09-26 1985-02-26 Eli Lilly And Company Trans-(±)-2,4,6-substituted-5,5a,6,7,8,9,9a,10-octahydro-pyrimido[4,5-g]quinolines
DE3417264A1 (en) * 1984-05-10 1985-11-14 Bayer Ag, 5090 Leverkusen NEW 2,4-DIAMINO-6-HALOGEN-5-ALKYLTHIO-PYRIMIDINE
DE3701277A1 (en) * 1987-01-17 1988-07-28 Boehringer Mannheim Gmbh NEW TRICYCLIC BENZIMIDAZOLES, METHOD FOR THEIR PRODUCTION AND USE AS MEDICINAL PRODUCTS
US4996198A (en) * 1988-07-11 1991-02-26 Hoffmann-La Roche Inc. Anticoccidial composition

Patent Citations (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2658897A (en) * 1951-06-27 1953-11-10 Burroughs Wellcome Co 2, 4-diamino-5-benzyl pyrimidines
FR1090394A (en) * 1953-03-11 1955-03-30 Wellcome Found Pyrimidine derivatives and their manufacture
FR1292920A (en) * 1959-04-18 1962-05-11 Wellcome Found Pyrimidine derivatives and their preparation
US3671564A (en) * 1965-10-28 1972-06-20 Burroughs Wellcome Co Benzylidene cyano-acetals
DE1720031A1 (en) * 1966-02-19 1972-08-03 Wellcome Found Biologically active 5-benzylpyrimidine derivatives and processes for their preparation
US4024145A (en) * 1973-11-08 1977-05-17 Hoffmann-La Roche Inc. Benzylpyrimidine derivatives
DE2617967A1 (en) * 1976-04-24 1977-11-03 Nordmark Werke Gmbh PROCESS FOR THE PREPARATION OF 2,4-DIAMINO-5-BENZYLPYRIMIDINES
FR2357563A1 (en) * 1976-07-09 1978-02-03 American Home Prod NEW 7H-PYRROLO (3,2-F) QUINAZOLINE-1,3-DIAMINES SUBSTITUTED IN POSITION 7, THEIR PROCESS FOR PREPARATION AND THE MEDICINAL PRODUCT CONTAINING THEM
LU77269A1 (en) * 1977-05-05 1979-01-18
LU77268A1 (en) * 1977-05-05 1979-01-18
EP0003212A1 (en) * 1977-11-10 1979-08-08 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft 2.4-Diamino-5-benzylpyrimidines, pharmaceutical compositions containing them and their preparation
US4233445A (en) * 1979-07-05 1980-11-11 American Home Products Corporation 7-(Substituted)-7H-pyrrolo[3.2-F]-quinazoline-1,3-diamines
US4258045A (en) * 1979-11-30 1981-03-24 Merck & Co., Inc. Inhibitor of dihydrofolate reductase
EP0054756A2 (en) * 1980-11-27 1982-06-30 The Wellcome Foundation Limited Antibacterial benzylpyrimidines
US4451466A (en) * 1982-07-02 1984-05-29 Shell Oil Company Use of pyrroloquinazolinediamines as pesticides
EP0122580A1 (en) * 1983-04-14 1984-10-24 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Pyrimidine derivatives, their preparation and pharmaceutical compositions

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO9208461A1 *

Also Published As

Publication number Publication date
JPH07509215A (en) 1995-10-12
EP0639075A1 (en) 1995-02-22
CA2095518A1 (en) 1992-05-15
AU657348B2 (en) 1995-03-09
PT99514A (en) 1992-10-30
PT99514B (en) 1999-04-30
WO1992008461A1 (en) 1992-05-29
AU2202792A (en) 1994-04-28
IE913974A1 (en) 1992-05-20

Similar Documents

Publication Publication Date Title
EP0577580A3 (en) Synthesis of sialoconjugates.
PL313619A1 (en) Derivatives of piperydine
PL310443A1 (en) Derivatives of pyrolo-pyridine
EP0459453A3 (en) Use of pravastatin for preventing onset of restenosis after angioplasty
PL306127A1 (en) Derivatives of epi-epibathydine
ZA925946B (en) Tetrahydroindazole tetrahydrocyclopentapyrazole and hexahydrocycloheptapyrazole compounds and their use as HMG-COA reductase inhibitors
EP0462661A3 (en) Novel 17beta-hydroxybenzoyl-4-aza-5alpha-androst-1-en-3-ones as testosterone reductase inhibitors
AU8551191A (en) Inhibition of scale
EP0652496A4 (en) Dial of timepiece and timepiece.
AU645142B2 (en) Corrosion inhibition
EP0323866A3 (en) Novel hmg-coa reductase inhibitors
EP0639075A4 (en) Specific inhibition of dihydrofolate reductase and compounds therefor.
EP0642337A1 (en) Dapsone and promin for the treatment of dementia.
GB9318000D0 (en) Inhibition of vascular restenosis
ZA919029B (en) Specific inhibition of dihydrofolate reductase and compounds therefor
EP0445827A3 (en) 4-hydroxytetrahydropyran-2-one derivatives and intermediates for synthesizing the same
EP0462665A3 (en) Selected 17beta-polyaroyl-4-aza-5alpha-androst-1-en-3-ones as steroidal reductase inhibitors
GB9303051D0 (en) 17b-nmonosubstituted carbamoyl-11-oxo-4-aza-5-a-androst-en-3-one testosterone-5-alpha reductase inhibitors
ZA929826B (en) Inhibitors of 5-alpha-testosterone reductase.
IL99377A0 (en) Synthesis of monohaloalkylferrocenes and the novel compound 4-chlorobutylferrocene
GB2251378B (en) Personal shower
GB2256435B (en) Destruction of waste
ZA904825B (en) Inhibition of potato-sprouting
ZA915920B (en) Destruction of waste.
AU1956692A (en) Method for inhibiting the development of body odors

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 19930505

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FR GB GR IT LI LU NL SE

17Q First examination report despatched

Effective date: 19970605

GRAG Despatch of communication of intention to grant

Free format text: ORIGINAL CODE: EPIDOS AGRA

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION HAS BEEN REFUSED

18R Application refused

Effective date: 19980801