MX3301E - PROCEDURE FOR PREPARING A DERIVATIVE OF PROSTAGLANDINA - Google Patents
PROCEDURE FOR PREPARING A DERIVATIVE OF PROSTAGLANDINAInfo
- Publication number
- MX3301E MX3301E MX000100U MX10076U MX3301E MX 3301 E MX3301 E MX 3301E MX 000100 U MX000100 U MX 000100U MX 10076 U MX10076 U MX 10076U MX 3301 E MX3301 E MX 3301E
- Authority
- MX
- Mexico
- Prior art keywords
- preparing
- derivative
- formula
- prostaglandina
- procedure
- Prior art date
Links
- 150000003180 prostaglandins Chemical class 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 230000001476 alcoholic effect Effects 0.000 abstract 1
- 239000003513 alkali Substances 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- -1 alkali metal salt Chemical class 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/04—Saturated compounds containing keto groups bound to acyclic carbon atoms
- C07C49/16—Saturated compounds containing keto groups bound to acyclic carbon atoms containing halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
- C07C51/377—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups
- C07C51/38—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups by decarboxylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/185—Saturated compounds having only one carboxyl group and containing keto groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F1/00—Compounds containing elements of Groups 1 or 11 of the Periodic Table
- C07F1/005—Compounds containing elements of Groups 1 or 11 of the Periodic Table without C-Metal linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/54—Quaternary phosphonium compounds
- C07F9/5407—Acyclic saturated phosphonium compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrrole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
La presente invención se refiere a un procedimiento para preparar un derivado de prostaglandina, de fórmula (VER FIGURA) caracterizada porque comprende saponificar un éster de fórmula general: (VER FIGURA) en la que R1 representa un grupo alquilo lineal o ramificado que contiene de 1 a 7 átomos de carbono, en un medio alcohólico, con un álcali, e hidrolizar la sal de metal alcalino resultante del compuesto de fórmula II con ácido fuerte, para formar el derivado de prostaglandina deseado.The present invention relates to a process for preparing a prostaglandin derivative of the formula (SEE FIGURE) characterized in that it comprises saponifying an ester of the general formula: (SEE FIGURE) in which R1 represents a linear or branched alkyl group containing 1 to 7 carbon atoms, in an alcoholic medium, with an alkali, and hydrolyze the resulting alkali metal salt of the compound of formula II with strong acid, to form the desired prostaglandin derivative.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB12034/75A GB1529852A (en) | 1975-03-21 | 1975-03-21 | 8-azaprostaglandins and process for the preparation thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX3301E true MX3301E (en) | 1980-09-03 |
Family
ID=9997230
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX000100U MX3301E (en) | 1975-03-21 | 1976-03-19 | PROCEDURE FOR PREPARING A DERIVATIVE OF PROSTAGLANDINA |
Country Status (26)
| Country | Link |
|---|---|
| JP (1) | JPS607602B2 (en) |
| AR (1) | AR213172A1 (en) |
| AT (1) | AT348163B (en) |
| AU (1) | AU501105B2 (en) |
| BE (1) | BE839761A (en) |
| CA (1) | CA1076587A (en) |
| CH (2) | CH611604A5 (en) |
| DE (1) | DE2612114A1 (en) |
| DK (1) | DK140937B (en) |
| ES (2) | ES446239A1 (en) |
| FI (1) | FI61692C (en) |
| FR (1) | FR2304340A1 (en) |
| GB (1) | GB1529852A (en) |
| HU (1) | HU173348B (en) |
| IE (1) | IE42966B1 (en) |
| IT (1) | IT1061011B (en) |
| MX (1) | MX3301E (en) |
| NL (1) | NL7602891A (en) |
| NO (1) | NO144147C (en) |
| NZ (1) | NZ180251A (en) |
| OA (1) | OA05279A (en) |
| PT (1) | PT64919B (en) |
| SE (1) | SE418290B (en) |
| SU (1) | SU614746A3 (en) |
| YU (1) | YU73876A (en) |
| ZA (1) | ZA761448B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4097489A (en) * | 1977-06-17 | 1978-06-27 | The Upjohn Company | 9-Deoxy-9α,6-nitrilo or 6,9α-imino-PGF compounds |
| US5540618A (en) * | 1994-10-28 | 1996-07-30 | National University Of Singapore | Passive attenuator for shelter protection against explosions |
| IL163866A0 (en) | 2002-03-05 | 2005-12-18 | Ono Pharmaceutical Co | 8-Azaprostaglandin derivative compounds and drugs containing the compounds s active ingredient |
-
1975
- 1975-03-21 GB GB12034/75A patent/GB1529852A/en not_active Expired
-
1976
- 1976-03-02 DK DK88276AA patent/DK140937B/en not_active IP Right Cessation
- 1976-03-09 NZ NZ180251A patent/NZ180251A/en unknown
- 1976-03-09 ZA ZA761448A patent/ZA761448B/en unknown
- 1976-03-11 AU AU11899/76A patent/AU501105B2/en not_active Expired
- 1976-03-15 IE IE545/76A patent/IE42966B1/en unknown
- 1976-03-17 AT AT195676A patent/AT348163B/en not_active IP Right Cessation
- 1976-03-18 SE SE7603400A patent/SE418290B/en unknown
- 1976-03-18 IT IT21346/76A patent/IT1061011B/en active
- 1976-03-18 PT PT64919A patent/PT64919B/en unknown
- 1976-03-18 FR FR7607794A patent/FR2304340A1/en active Granted
- 1976-03-19 AR AR262630A patent/AR213172A1/en active
- 1976-03-19 CA CA248,275A patent/CA1076587A/en not_active Expired
- 1976-03-19 FI FI760744A patent/FI61692C/en not_active IP Right Cessation
- 1976-03-19 YU YU00738/76A patent/YU73876A/en unknown
- 1976-03-19 NO NO760994A patent/NO144147C/en unknown
- 1976-03-19 NL NL7602891A patent/NL7602891A/en not_active Application Discontinuation
- 1976-03-19 BE BE165326A patent/BE839761A/en not_active IP Right Cessation
- 1976-03-19 MX MX000100U patent/MX3301E/en unknown
- 1976-03-19 CH CH350176A patent/CH611604A5/en not_active IP Right Cessation
- 1976-03-19 SU SU762334454A patent/SU614746A3/en active
- 1976-03-19 HU HU76LA885A patent/HU173348B/en unknown
- 1976-03-19 CH CH844678A patent/CH611881A5/en not_active IP Right Cessation
- 1976-03-20 OA OA55774A patent/OA05279A/en unknown
- 1976-03-20 ES ES446239A patent/ES446239A1/en not_active Expired
- 1976-03-22 JP JP51031889A patent/JPS607602B2/en not_active Expired
- 1976-03-22 DE DE19762612114 patent/DE2612114A1/en not_active Withdrawn
-
1977
- 1977-05-03 ES ES458389A patent/ES458389A1/en not_active Expired
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