JPS57109722A - Antitumor agent containing deoxyfluorouridine benzyloxylated at 4-position - Google Patents
Antitumor agent containing deoxyfluorouridine benzyloxylated at 4-positionInfo
- Publication number
- JPS57109722A JPS57109722A JP18606080A JP18606080A JPS57109722A JP S57109722 A JPS57109722 A JP S57109722A JP 18606080 A JP18606080 A JP 18606080A JP 18606080 A JP18606080 A JP 18606080A JP S57109722 A JPS57109722 A JP S57109722A
- Authority
- JP
- Japan
- Prior art keywords
- benzyloxylated
- deoxyfluorouridine
- compound
- agent containing
- antitumor agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PURPOSE: To provide an antitumor agent containing deoxyfluorouridine benzyloxylated at 4-position as an active component.
CONSTITUTION: An antitumor agent containing 4-benzyloxylated deoxyfluorouridine of formulaI(R is H, halogen or 1W4C alkyl; n is 3 or 4). It is administered pref. as an oral drug such as tablet, capsule, etc. at a dose of 1W600mg daily. It has higher antitumor activity than known 5-fluorouracil compound. The compound of formulaIcan be prepared by reacting, e.g. the compound of formula II with the compound of formula III (hal is halogen) in the presence of a copper compound.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP18606080A JPS57109722A (en) | 1980-12-26 | 1980-12-26 | Antitumor agent containing deoxyfluorouridine benzyloxylated at 4-position |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP18606080A JPS57109722A (en) | 1980-12-26 | 1980-12-26 | Antitumor agent containing deoxyfluorouridine benzyloxylated at 4-position |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS57109722A true JPS57109722A (en) | 1982-07-08 |
JPS6312446B2 JPS6312446B2 (en) | 1988-03-18 |
Family
ID=16181682
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP18606080A Granted JPS57109722A (en) | 1980-12-26 | 1980-12-26 | Antitumor agent containing deoxyfluorouridine benzyloxylated at 4-position |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS57109722A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0686641A4 (en) * | 1993-12-24 | 1996-07-10 | Taiho Pharmaceutical Co Ltd | 2'-deoxy-5-fluorouridine derivative, pharmaceutically acceptable salt thereof, process for producing the same, and antitumor drug |
-
1980
- 1980-12-26 JP JP18606080A patent/JPS57109722A/en active Granted
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0686641A4 (en) * | 1993-12-24 | 1996-07-10 | Taiho Pharmaceutical Co Ltd | 2'-deoxy-5-fluorouridine derivative, pharmaceutically acceptable salt thereof, process for producing the same, and antitumor drug |
US5869464A (en) * | 1993-12-24 | 1999-02-09 | Taiho Pharmaceutical Co. Ltd. | 2'-Deoxy-5-fluorouridine derivatives, a process for their preparation, antitumor agents containing same and methods for using said agents |
Also Published As
Publication number | Publication date |
---|---|
JPS6312446B2 (en) | 1988-03-18 |
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