JPS57109721A - Carcinostatic agent - Google Patents

Carcinostatic agent

Info

Publication number
JPS57109721A
JPS57109721A JP18545180A JP18545180A JPS57109721A JP S57109721 A JPS57109721 A JP S57109721A JP 18545180 A JP18545180 A JP 18545180A JP 18545180 A JP18545180 A JP 18545180A JP S57109721 A JPS57109721 A JP S57109721A
Authority
JP
Grant status
Application
Patent type
Prior art keywords
compound
halogen
etc
active component
carcinostatic agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP18545180A
Other versions
JPS6147808B2 (en )
Inventor
Noboru Fujikawa
Takahiro Haga
Kuniaki Hase
Hiroyuki Mori
Ryuzo Nishiyama
Yasuo Ogawa
Original Assignee
Ishihara Sangyo Kaisha Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Abstract

PURPOSE: To provide a carcinostatic agent containing a specific benzoylurea compound as an active component.
CONSTITUTION: A benzoylurea compound of formulaI(X is halogen or nitro; Y and Z2 is H or halogen; Z1 is halogen or CF3; A is =CH-, or =N-) is used as an active component. It is administered in the form of oral drug such as capsules, tablets, etc. or injection, etc. Dose: about 5W1,000mg, pref. about 50W500mg per kg of the body weight daily. The compound of formulaIcan be prepared by reacting e.g. the compound of formula II with the compound of formula III in a solvent such as benzene.
COPYRIGHT: (C)1982,JPO&Japio
JP18545180A 1980-12-27 1980-12-27 Expired JPS6147808B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP18545180A JPS6147808B2 (en) 1980-12-27 1980-12-27

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP18545180A JPS6147808B2 (en) 1980-12-27 1980-12-27

Publications (2)

Publication Number Publication Date
JPS57109721A true true JPS57109721A (en) 1982-07-08
JPS6147808B2 JPS6147808B2 (en) 1986-10-21

Family

ID=16171022

Family Applications (1)

Application Number Title Priority Date Filing Date
JP18545180A Expired JPS6147808B2 (en) 1980-12-27 1980-12-27

Country Status (1)

Country Link
JP (1) JPS6147808B2 (en)

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0164694A2 (en) * 1984-06-15 1985-12-18 Ishihara Sangyo Kaisha, Ltd. N-Benzoyl-N'-pyrimidinyloxyphenyl urea compounds, and antitumorous compositions containing them, and process for their preparation
JPS611670A (en) * 1984-06-15 1986-01-07 Ishihara Sangyo Kaisha Ltd N-benzoyl-n'-pyrimidinylurea and anticancer containing the same
EP0169484A2 (en) * 1984-07-24 1986-01-29 Ishihara Sangyo Kaisha, Ltd. N-benzoyl-N'-pyridazinyloxyphenyl urea compounds, and antitumorous compositions containing them, and process for their preparation
EP0178572A2 (en) * 1984-10-12 1986-04-23 Ishihara Sangyo Kaisha, Ltd. N-Benzoyl-N'-(3-Nitrophenyl) urea compounds, and antitumorous compositions containing them, and process for their preparation
FR2577551A1 (en) * 1985-02-20 1986-08-22 Ishihara Mining & Chemical Co Benzoyl urea derivatives, process for their preparation, and antitumor compositions containing
JPS61191623A (en) * 1985-02-20 1986-08-26 Green Cross Corp:The Easily absorbable medicinal composition
EP0193249A2 (en) * 1985-03-01 1986-09-03 Duphar International Research B.V Benzoyl urea derivatives having ati-tumor activity
JPS61205257A (en) * 1985-03-08 1986-09-11 Green Cross Corp:The Benzoylurea compound, production thereof, and anticancer drug containing same
JPS6479154A (en) * 1986-09-29 1989-03-24 Green Cross Corp Benzoylurea compound
US4983605A (en) * 1986-10-23 1991-01-08 Ishihara Sangyo Kaisha Ltd. Pharmaceutical composition
US5116949A (en) * 1988-09-12 1992-05-26 Ishihara Sangyo Kaisha Ltd. Benzoyl urea compound-albumin complex

Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0164694A2 (en) * 1984-06-15 1985-12-18 Ishihara Sangyo Kaisha, Ltd. N-Benzoyl-N'-pyrimidinyloxyphenyl urea compounds, and antitumorous compositions containing them, and process for their preparation
JPS611670A (en) * 1984-06-15 1986-01-07 Ishihara Sangyo Kaisha Ltd N-benzoyl-n'-pyrimidinylurea and anticancer containing the same
US4677110A (en) * 1984-06-15 1987-06-30 Ishihara Sangyo Kaisha Ltd. N-benzoyl-N'-pyrimidinyloxyphenyl urea compounds, and antitumorous compositions containing them
EP0169484A2 (en) * 1984-07-24 1986-01-29 Ishihara Sangyo Kaisha, Ltd. N-benzoyl-N'-pyridazinyloxyphenyl urea compounds, and antitumorous compositions containing them, and process for their preparation
EP0169484B1 (en) * 1984-07-24 1990-10-17 Ishihara Sangyo Kaisha, Ltd. N-benzoyl-n'-pyridazinyloxyphenyl urea compounds, and antitumorous compositions containing them, and process for their preparation
EP0178572A2 (en) * 1984-10-12 1986-04-23 Ishihara Sangyo Kaisha, Ltd. N-Benzoyl-N'-(3-Nitrophenyl) urea compounds, and antitumorous compositions containing them, and process for their preparation
JPS6193163A (en) * 1984-10-12 1986-05-12 Ishihara Sangyo Kaisha Ltd N-benzoyl-n'-phenylurea compound, its preparation and carcinostatic agent containing same
US4677111A (en) * 1984-10-12 1987-06-30 Ishihara Sangyo Kaisha Ltd. N-benzoyl-N'-(3-nitrophenyl) urea compounds, and antitumorous compositions containing them
EP0192263A2 (en) * 1985-02-20 1986-08-27 Ishihara Sangyo Kaisha Ltd. Readily absorbable pharmaceutical composition
US4727077A (en) * 1985-02-20 1988-02-23 Ishihara Sangyo Kaisha Ltd. Benzoyl urea compounds, process for their production, and antitumorous compositions containing them
JPS61191623A (en) * 1985-02-20 1986-08-26 Green Cross Corp:The Easily absorbable medicinal composition
FR2577551A1 (en) * 1985-02-20 1986-08-22 Ishihara Mining & Chemical Co Benzoyl urea derivatives, process for their preparation, and antitumor compositions containing
US4849425A (en) * 1985-02-20 1989-07-18 Ishihara Sangyo Kaisha Ltd. Readily absorbable pharmaceutical composition
EP0193249A2 (en) * 1985-03-01 1986-09-03 Duphar International Research B.V Benzoyl urea derivatives having ati-tumor activity
JPS61205257A (en) * 1985-03-08 1986-09-11 Green Cross Corp:The Benzoylurea compound, production thereof, and anticancer drug containing same
JPH0156065B2 (en) * 1985-03-08 1989-11-28 Ishihara Sangyo Kk
JPS6479154A (en) * 1986-09-29 1989-03-24 Green Cross Corp Benzoylurea compound
US4983605A (en) * 1986-10-23 1991-01-08 Ishihara Sangyo Kaisha Ltd. Pharmaceutical composition
US5116949A (en) * 1988-09-12 1992-05-26 Ishihara Sangyo Kaisha Ltd. Benzoyl urea compound-albumin complex

Also Published As

Publication number Publication date Type
JPS6147808B2 (en) 1986-10-21 grant

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