JPS5569569A - Carcinostatic - Google Patents
CarcinostaticInfo
- Publication number
- JPS5569569A JPS5569569A JP14281078A JP14281078A JPS5569569A JP S5569569 A JPS5569569 A JP S5569569A JP 14281078 A JP14281078 A JP 14281078A JP 14281078 A JP14281078 A JP 14281078A JP S5569569 A JPS5569569 A JP S5569569A
- Authority
- JP
- Japan
- Prior art keywords
- carcinostatic
- fluorouracil
- aralkylcarbamoyl
- compound
- oral administration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
PURPOSE: A carcinostatic suitable for oral administration, having improved carcinostatic activity, with low toxicity, comprising an 1-aralkylcarbamoyl-5-fluorouracil derivative as an active constituent.
CONSTITUTION: A carcinostatic comprising an 1-aralkylcarbamoyl-5-fluorouracil derivative, e.g. 1-phenethylcarbamoyl- or 1-benzylcarbamoyl-5-fluorouracil, of the formula (R is H, lower alkyl, alkoxy, or alkoxycarbonyl group ; m and n are 1 or 2) as an active constituent. The compound with low toxicity shows a great carcinostatic activity against slowly growing cancer, and is suitable for oral administration in a dose of preferably 50W1500mg/day.adult. The compound can be prepared from addition reaction of 5-fluorouracil with the corresponding isocyanate.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP14281078A JPS5569569A (en) | 1978-11-21 | 1978-11-21 | Carcinostatic |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP14281078A JPS5569569A (en) | 1978-11-21 | 1978-11-21 | Carcinostatic |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5569569A true JPS5569569A (en) | 1980-05-26 |
Family
ID=15324149
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP14281078A Pending JPS5569569A (en) | 1978-11-21 | 1978-11-21 | Carcinostatic |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5569569A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3301107A1 (en) * | 1983-01-14 | 1984-07-19 | Ozaki, Shoichiro, Ehime | Novel 1-(N-substituted carbamoyl)-5-fluorouracil derivatives and anti-cancer agents which contain them as active constituents |
FR2539412A1 (en) * | 1983-01-13 | 1984-07-20 | Shoichiro Ozaki | 5-Fluorouracil derivatives and their therapeutic uses as carcinostatic agents |
-
1978
- 1978-11-21 JP JP14281078A patent/JPS5569569A/en active Pending
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2539412A1 (en) * | 1983-01-13 | 1984-07-20 | Shoichiro Ozaki | 5-Fluorouracil derivatives and their therapeutic uses as carcinostatic agents |
DE3301107A1 (en) * | 1983-01-14 | 1984-07-19 | Ozaki, Shoichiro, Ehime | Novel 1-(N-substituted carbamoyl)-5-fluorouracil derivatives and anti-cancer agents which contain them as active constituents |
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