JPS55153796A - 5-fluorouracil nucleoside and its preparation - Google Patents

5-fluorouracil nucleoside and its preparation

Info

Publication number
JPS55153796A
JPS55153796A JP6149179A JP6149179A JPS55153796A JP S55153796 A JPS55153796 A JP S55153796A JP 6149179 A JP6149179 A JP 6149179A JP 6149179 A JP6149179 A JP 6149179A JP S55153796 A JPS55153796 A JP S55153796A
Authority
JP
Japan
Prior art keywords
fluorouracil
group
formula
sugar
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP6149179A
Other languages
Japanese (ja)
Inventor
Masao Koyama
Shunzo Fukatsu
Mitsuru Hisamatsu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Meiji Seika Kaisha Ltd
Original Assignee
Meiji Seika Kaisha Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Meiji Seika Kaisha Ltd filed Critical Meiji Seika Kaisha Ltd
Priority to JP6149179A priority Critical patent/JPS55153796A/en
Publication of JPS55153796A publication Critical patent/JPS55153796A/en
Pending legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

NEW MATERIAL:A 5-fluorouracil nucleoside of formula I (R1 is H or OH; R2 is OH; either of R3 and R4 is OH, and the other is H; either of R5 and R6 is H, methyl or hydroxymethyl group, and the other is H).
EXAMPLE: 1-(β-D-Ribopyranosyl)-5-fluorouracil.
USE: A medicine having an antitumor activity with low toxicity.
PROCESS: A solubilized 5-fluorouracil, e.g. 2,4-bis-0-trimethylsilyl-5-fluorouracil, is reacted with a reactive derivative wherein the OH group of sugar expressed by formula II (R is acyloxy group; Ra 1 is H or OH; Ra 2 is OH; either of Ra 3 and Ra 4 is H, and the other is methyl group, etc.), is protected, e.g. polyacyl sugar, in the presence of a Lewis acid catalyst, e.g. stannic chloride, in an inert solvent. The reaction product is then hydrolyzed with an alkali to give the compound of formula I free of the protecting group.
COPYRIGHT: (C)1980,JPO&Japio
JP6149179A 1979-05-21 1979-05-21 5-fluorouracil nucleoside and its preparation Pending JPS55153796A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP6149179A JPS55153796A (en) 1979-05-21 1979-05-21 5-fluorouracil nucleoside and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP6149179A JPS55153796A (en) 1979-05-21 1979-05-21 5-fluorouracil nucleoside and its preparation

Publications (1)

Publication Number Publication Date
JPS55153796A true JPS55153796A (en) 1980-11-29

Family

ID=13172609

Family Applications (1)

Application Number Title Priority Date Filing Date
JP6149179A Pending JPS55153796A (en) 1979-05-21 1979-05-21 5-fluorouracil nucleoside and its preparation

Country Status (1)

Country Link
JP (1) JPS55153796A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997000882A1 (en) * 1995-06-23 1997-01-09 Oxford Glycosciences (Uk) Limited Therapeutic compounds
JP2001517674A (en) * 1997-09-22 2001-10-09 アヴェンティス・リサーチ・ウント・テクノロジーズ・ゲーエムベーハー・ウント・コー・カーゲー Pentopyranosyl nucleosides, their production and use

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997000882A1 (en) * 1995-06-23 1997-01-09 Oxford Glycosciences (Uk) Limited Therapeutic compounds
US5945406A (en) * 1995-06-23 1999-08-31 Oxford Glycosciences (Uk) Ltd. Therapeutic compounds with pyrimidine base
JP2001517674A (en) * 1997-09-22 2001-10-09 アヴェンティス・リサーチ・ウント・テクノロジーズ・ゲーエムベーハー・ウント・コー・カーゲー Pentopyranosyl nucleosides, their production and use
JP2001517676A (en) * 1997-09-22 2001-10-09 アヴェンティス・リサーチ・ウント・テクノロジーズ・ゲーエムベーハー・ウント・コー・カーゲー Use of pentopyranosyl nucleosides for making electronic components and pentopyranosyl nucleoside conjugates
JP2001517675A (en) * 1997-09-22 2001-10-09 アヴェンティス・リサーチ・ウント・テクノロジーズ・ゲーエムベーハー・ウント・コー・カーゲー Method for producing pentopyranosyl nucleoside
JP4674965B2 (en) * 1997-09-22 2011-04-20 ナノジェン・レコグノミクス・ゲーエムベーハー Use of pentopyranosyl nucleosides to produce electronic components and pentopyranosyl nucleoside conjugates
JP4674964B2 (en) * 1997-09-22 2011-04-20 ナノジェン・レコグノミクス・ゲーエムベーハー Pentopyranosyl nucleoside, its manufacture and use

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