JPS55153796A - 5-fluorouracil nucleoside and its preparation - Google Patents
5-fluorouracil nucleoside and its preparationInfo
- Publication number
- JPS55153796A JPS55153796A JP6149179A JP6149179A JPS55153796A JP S55153796 A JPS55153796 A JP S55153796A JP 6149179 A JP6149179 A JP 6149179A JP 6149179 A JP6149179 A JP 6149179A JP S55153796 A JPS55153796 A JP S55153796A
- Authority
- JP
- Japan
- Prior art keywords
- fluorouracil
- group
- formula
- sugar
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
NEW MATERIAL:A 5-fluorouracil nucleoside of formula I (R1 is H or OH; R2 is OH; either of R3 and R4 is OH, and the other is H; either of R5 and R6 is H, methyl or hydroxymethyl group, and the other is H).
EXAMPLE: 1-(β-D-Ribopyranosyl)-5-fluorouracil.
USE: A medicine having an antitumor activity with low toxicity.
PROCESS: A solubilized 5-fluorouracil, e.g. 2,4-bis-0-trimethylsilyl-5-fluorouracil, is reacted with a reactive derivative wherein the OH group of sugar expressed by formula II (R is acyloxy group; Ra 1 is H or OH; Ra 2 is OH; either of Ra 3 and Ra 4 is H, and the other is methyl group, etc.), is protected, e.g. polyacyl sugar, in the presence of a Lewis acid catalyst, e.g. stannic chloride, in an inert solvent. The reaction product is then hydrolyzed with an alkali to give the compound of formula I free of the protecting group.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP6149179A JPS55153796A (en) | 1979-05-21 | 1979-05-21 | 5-fluorouracil nucleoside and its preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP6149179A JPS55153796A (en) | 1979-05-21 | 1979-05-21 | 5-fluorouracil nucleoside and its preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS55153796A true JPS55153796A (en) | 1980-11-29 |
Family
ID=13172609
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP6149179A Pending JPS55153796A (en) | 1979-05-21 | 1979-05-21 | 5-fluorouracil nucleoside and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS55153796A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997000882A1 (en) * | 1995-06-23 | 1997-01-09 | Oxford Glycosciences (Uk) Limited | Therapeutic compounds |
JP2001517674A (en) * | 1997-09-22 | 2001-10-09 | アヴェンティス・リサーチ・ウント・テクノロジーズ・ゲーエムベーハー・ウント・コー・カーゲー | Pentopyranosyl nucleosides, their production and use |
-
1979
- 1979-05-21 JP JP6149179A patent/JPS55153796A/en active Pending
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997000882A1 (en) * | 1995-06-23 | 1997-01-09 | Oxford Glycosciences (Uk) Limited | Therapeutic compounds |
US5945406A (en) * | 1995-06-23 | 1999-08-31 | Oxford Glycosciences (Uk) Ltd. | Therapeutic compounds with pyrimidine base |
JP2001517674A (en) * | 1997-09-22 | 2001-10-09 | アヴェンティス・リサーチ・ウント・テクノロジーズ・ゲーエムベーハー・ウント・コー・カーゲー | Pentopyranosyl nucleosides, their production and use |
JP2001517676A (en) * | 1997-09-22 | 2001-10-09 | アヴェンティス・リサーチ・ウント・テクノロジーズ・ゲーエムベーハー・ウント・コー・カーゲー | Use of pentopyranosyl nucleosides for making electronic components and pentopyranosyl nucleoside conjugates |
JP2001517675A (en) * | 1997-09-22 | 2001-10-09 | アヴェンティス・リサーチ・ウント・テクノロジーズ・ゲーエムベーハー・ウント・コー・カーゲー | Method for producing pentopyranosyl nucleoside |
JP4674965B2 (en) * | 1997-09-22 | 2011-04-20 | ナノジェン・レコグノミクス・ゲーエムベーハー | Use of pentopyranosyl nucleosides to produce electronic components and pentopyranosyl nucleoside conjugates |
JP4674964B2 (en) * | 1997-09-22 | 2011-04-20 | ナノジェン・レコグノミクス・ゲーエムベーハー | Pentopyranosyl nucleoside, its manufacture and use |
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