JPS5728100A - Tylosin derivative - Google Patents

Tylosin derivative

Info

Publication number
JPS5728100A
JPS5728100A JP10193380A JP10193380A JPS5728100A JP S5728100 A JPS5728100 A JP S5728100A JP 10193380 A JP10193380 A JP 10193380A JP 10193380 A JP10193380 A JP 10193380A JP S5728100 A JPS5728100 A JP S5728100A
Authority
JP
Japan
Prior art keywords
formula
give
deoxy
mycaminosyl
alkanoyloxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP10193380A
Other languages
Japanese (ja)
Other versions
JPS632276B2 (en
Inventor
Akihiro Tanaka
Osamu Tsuchiya
Sumio Umezawa
Hamao Umezawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Microbial Chemistry Research Foundation
Original Assignee
Microbial Chemistry Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microbial Chemistry Research Foundation filed Critical Microbial Chemistry Research Foundation
Priority to JP10193380A priority Critical patent/JPS5728100A/en
Priority to US06/285,747 priority patent/US4438109A/en
Priority to GB8122796A priority patent/GB2081711B/en
Priority to DE19813129112 priority patent/DE3129112A1/en
Priority to CA000382401A priority patent/CA1202621A/en
Priority to CH4830/81A priority patent/CH650513A5/en
Priority to ES81504282A priority patent/ES8301975A1/en
Priority to FR8114456A priority patent/FR2495620A1/en
Publication of JPS5728100A publication Critical patent/JPS5728100A/en
Priority to ES514429A priority patent/ES8306144A1/en
Publication of JPS632276B2 publication Critical patent/JPS632276B2/ja
Granted legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

NEW MATERIAL:Tylosin derivatives of formula I (R2 is H, hydroxyl, alkanoyloxy; R2 is hydroxyl, alkanoyloxy; dotted line means a single or double bond and, when R1 is H, it is double bond).
EXAMPLE: 3,23-Di-0-acetyl-4'-deoxy mycaminosyl tylonolide.
USE: Antibiotic: they show excellent antibiotic activity and they have a characteristic structure that mycaminosyl thlonolide is made in the deoxy form at the 4' position and simultaneously the 3 and 23 positons are substituted.
PREPARATION: Mycaminosyl tylonolide bearing protected aldehyde in the 18 position of formula II is made to react with benzylsulfonic acid and subsequently with an alkali metal halide to give a halogen-substituted product at the 4' position of formula IV. The dehalogenation at the 4' position is effected to give the deoxy compound of formula V and the protecting group of the aldehyde group is removed to give the compound of formula I.
COPYRIGHT: (C)1982,JPO&Japio
JP10193380A 1980-07-25 1980-07-25 Tylosin derivative Granted JPS5728100A (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
JP10193380A JPS5728100A (en) 1980-07-25 1980-07-25 Tylosin derivative
US06/285,747 US4438109A (en) 1980-07-25 1981-07-22 Tylosin derivatives
GB8122796A GB2081711B (en) 1980-07-25 1981-07-23 Tylosin derivatives
DE19813129112 DE3129112A1 (en) 1980-07-25 1981-07-23 TYLOSIN DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF
CA000382401A CA1202621A (en) 1980-07-25 1981-07-23 Process for producing tylosin derivatives
CH4830/81A CH650513A5 (en) 1980-07-25 1981-07-24 TYLOSIN DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF.
ES81504282A ES8301975A1 (en) 1980-07-25 1981-07-24 A procedure for the production of a tilosine derivative (Machine-translation by Google Translate, not legally binding)
FR8114456A FR2495620A1 (en) 1980-07-25 1981-07-24 DERIVATIVES OF TYLOSINE
ES514429A ES8306144A1 (en) 1980-07-25 1982-07-27 Tylosin derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP10193380A JPS5728100A (en) 1980-07-25 1980-07-25 Tylosin derivative

Publications (2)

Publication Number Publication Date
JPS5728100A true JPS5728100A (en) 1982-02-15
JPS632276B2 JPS632276B2 (en) 1988-01-18

Family

ID=14313709

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10193380A Granted JPS5728100A (en) 1980-07-25 1980-07-25 Tylosin derivative

Country Status (1)

Country Link
JP (1) JPS5728100A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5933298A (en) * 1982-08-19 1984-02-23 Microbial Chem Res Found Tylosin derivative
WO1993014101A1 (en) * 1992-01-14 1993-07-22 Zaidan Hojin Biseibutsu Kagaku Kenkyukai 3,4'-dideoxymycaminosyltylonolide derivative and production thereof

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5933298A (en) * 1982-08-19 1984-02-23 Microbial Chem Res Found Tylosin derivative
JPH039918B2 (en) * 1982-08-19 1991-02-12 Microbial Chem Res Found
WO1993014101A1 (en) * 1992-01-14 1993-07-22 Zaidan Hojin Biseibutsu Kagaku Kenkyukai 3,4'-dideoxymycaminosyltylonolide derivative and production thereof
US5541303A (en) * 1992-01-14 1996-07-30 Zaidan Hojin Biseibutsu Kagaku Kenkyukai 3,4'-dideoxymycaminosltylonolide derivative and process for producing the same

Also Published As

Publication number Publication date
JPS632276B2 (en) 1988-01-18

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