JPS55149299A - N6-substituted cordicepin derivative and its preparation - Google Patents

N6-substituted cordicepin derivative and its preparation

Info

Publication number
JPS55149299A
JPS55149299A JP5443979A JP5443979A JPS55149299A JP S55149299 A JPS55149299 A JP S55149299A JP 5443979 A JP5443979 A JP 5443979A JP 5443979 A JP5443979 A JP 5443979A JP S55149299 A JPS55149299 A JP S55149299A
Authority
JP
Japan
Prior art keywords
substituted
formula
derivative
cordycepin
cordicepin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP5443979A
Other languages
Japanese (ja)
Other versions
JPS5919557B2 (en
Inventor
Susumu Shibuya
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yamasa Shoyu KK
Original Assignee
Yamasa Shoyu KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamasa Shoyu KK filed Critical Yamasa Shoyu KK
Priority to JP54054439A priority Critical patent/JPS5919557B2/en
Publication of JPS55149299A publication Critical patent/JPS55149299A/en
Publication of JPS5919557B2 publication Critical patent/JPS5919557B2/en
Expired legal-status Critical Current

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  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:An N6-substituted Cordycepin derivative of formula I [R is alkyl or (substituted) allyl group].
EXAMPLE: N6-Acetylcordycepin.
USE: An antimicrobial and antitumor agent having resistance to adenosine deaminase, and useful as a prodrug of Cordycepin.
PROCESS: Cordycepin of formula II is reacted with an acid anhydride of halogenide of formula III or IV (X is halogen) in a solvent, e.g. pyridine, to give a compound of formula V (R' is H or R), which is hydrolyzed in an alkali to form the compound of formula I.
COPYRIGHT: (C)1980,JPO&Japio
JP54054439A 1979-05-02 1979-05-02 N↑6-substituted cordycepin derivative and method for producing the same Expired JPS5919557B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP54054439A JPS5919557B2 (en) 1979-05-02 1979-05-02 N↑6-substituted cordycepin derivative and method for producing the same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP54054439A JPS5919557B2 (en) 1979-05-02 1979-05-02 N↑6-substituted cordycepin derivative and method for producing the same

Publications (2)

Publication Number Publication Date
JPS55149299A true JPS55149299A (en) 1980-11-20
JPS5919557B2 JPS5919557B2 (en) 1984-05-07

Family

ID=12970734

Family Applications (1)

Application Number Title Priority Date Filing Date
JP54054439A Expired JPS5919557B2 (en) 1979-05-02 1979-05-02 N↑6-substituted cordycepin derivative and method for producing the same

Country Status (1)

Country Link
JP (1) JPS5919557B2 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0668290A1 (en) * 1990-02-28 1995-08-23 Teikoku Seiyaku Co., Ltd. Physiologically active substance well capable of permeating biomembrane
US5652335A (en) * 1990-02-28 1997-07-29 Teikoku Seiyaku Kabushiki Kaisha Physiologically active substance well capable of permeating biomembrane
CN101993465A (en) * 2009-08-17 2011-03-30 重庆和润生物工程有限公司 New process for synthesizing N-alkanoyl cordycepin serving as cordycepin derivative by one-step method

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6311355U (en) * 1986-07-08 1988-01-25
JPS6379374U (en) * 1986-11-14 1988-05-25

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0668290A1 (en) * 1990-02-28 1995-08-23 Teikoku Seiyaku Co., Ltd. Physiologically active substance well capable of permeating biomembrane
US5652335A (en) * 1990-02-28 1997-07-29 Teikoku Seiyaku Kabushiki Kaisha Physiologically active substance well capable of permeating biomembrane
CN101993465A (en) * 2009-08-17 2011-03-30 重庆和润生物工程有限公司 New process for synthesizing N-alkanoyl cordycepin serving as cordycepin derivative by one-step method

Also Published As

Publication number Publication date
JPS5919557B2 (en) 1984-05-07

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