JPS5632496A - N6-omega-aminoalkyladenosine-3',5'-cyclic monophosphate and its preparation - Google Patents

N6-omega-aminoalkyladenosine-3',5'-cyclic monophosphate and its preparation

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Publication number
JPS5632496A
JPS5632496A JP10838079A JP10838079A JPS5632496A JP S5632496 A JPS5632496 A JP S5632496A JP 10838079 A JP10838079 A JP 10838079A JP 10838079 A JP10838079 A JP 10838079A JP S5632496 A JPS5632496 A JP S5632496A
Authority
JP
Japan
Prior art keywords
formula
cyclic monophosphate
monophosphate
cyclic
aminoalkyladenosine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP10838079A
Other languages
Japanese (ja)
Inventor
Kazuo Fujiyama
Masatsune Ichikawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yamasa Shoyu KK
Original Assignee
Yamasa Shoyu KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamasa Shoyu KK filed Critical Yamasa Shoyu KK
Priority to JP10838079A priority Critical patent/JPS5632496A/en
Publication of JPS5632496A publication Critical patent/JPS5632496A/en
Pending legal-status Critical Current

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:The titled phosphate (salt) expressed by formula I (n is an integer 1W20).
EXAMPLE: N6-(2-aminoethyl)-adenosine-3',5'-cyclic monophsophate.
USE: An antiallergic agent.
PROCESS: After protecting the hydroxyl group at the 2'-position with an acyl group, inosine-3',5'-cyclic monophosphate is reacted with phosphorus oxychloride in a solvent, e.g. diethylaniline, to give a 6-halogenopurine-9-β-D-ribofuranosyl-3',5'-cyclic monophosphate (salt) expressed by formula II (X is halogen), which is then reacted with a 1,ω-diaminoalkane of the formula H2N (CH2)nNH2 (n is an integer 1W20) at an equivalent ratio between the monophosphate and the 1,ω-diaminoalkane of 1:1.5W1:10 at room temperatureW100°C for 1Wseveral tens of hours to give the compound of formula I.
COPYRIGHT: (C)1981,JPO&Japio
JP10838079A 1979-08-24 1979-08-24 N6-omega-aminoalkyladenosine-3',5'-cyclic monophosphate and its preparation Pending JPS5632496A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP10838079A JPS5632496A (en) 1979-08-24 1979-08-24 N6-omega-aminoalkyladenosine-3',5'-cyclic monophosphate and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP10838079A JPS5632496A (en) 1979-08-24 1979-08-24 N6-omega-aminoalkyladenosine-3',5'-cyclic monophosphate and its preparation

Publications (1)

Publication Number Publication Date
JPS5632496A true JPS5632496A (en) 1981-04-01

Family

ID=14483296

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10838079A Pending JPS5632496A (en) 1979-08-24 1979-08-24 N6-omega-aminoalkyladenosine-3',5'-cyclic monophosphate and its preparation

Country Status (1)

Country Link
JP (1) JPS5632496A (en)

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