JPS5677298A - Movel 5-fluorouridine derivative and its preparation - Google Patents

Movel 5-fluorouridine derivative and its preparation

Info

Publication number
JPS5677298A
JPS5677298A JP15292279A JP15292279A JPS5677298A JP S5677298 A JPS5677298 A JP S5677298A JP 15292279 A JP15292279 A JP 15292279A JP 15292279 A JP15292279 A JP 15292279A JP S5677298 A JPS5677298 A JP S5677298A
Authority
JP
Japan
Prior art keywords
fluorouridine
movel
preparation
acyl
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP15292279A
Other languages
Japanese (ja)
Other versions
JPS621399B2 (en
Inventor
Takeshi Endo
Katsumi Sakai
Kiyoaki Cho
Yoshitaka Inamoto
Haruhiko Teshigahara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fuji Chemical Industries Co Ltd
Original Assignee
Fuji Chemical Industries Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fuji Chemical Industries Co Ltd filed Critical Fuji Chemical Industries Co Ltd
Priority to JP15292279A priority Critical patent/JPS5677298A/en
Priority to US06/210,796 priority patent/US4340728A/en
Priority to IT26289/80A priority patent/IT1141100B/en
Priority to DE19803044740 priority patent/DE3044740A1/en
Priority to FR8025348A priority patent/FR2470774A1/en
Priority to GB8038211A priority patent/GB2066812B/en
Priority to CH883380A priority patent/CH646441A5/en
Publication of JPS5677298A publication Critical patent/JPS5677298A/en
Publication of JPS621399B2 publication Critical patent/JPS621399B2/ja
Granted legal-status Critical Current

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  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A 5-fluorouridine-5'-ester derivative shown by the formula (A is N-acyl-α-aminocarboxy).
EXAMPLE: 5'-O-(N-benzyloxycarbonylmethionyl)-5-fluorouridine.
USE: An anti-malignant tumor, antiviral agnet, immunosuppressive agent, and their intermediates.
PROCESS: N-Acyl-α-aminocarboxylic acid is reacted with 2'3'-O-alkylidene-5-fluorouridine in an anhydrous solvent, e.g., benzene, in the presence of a basic compound, e.g., trialkylamine, pyridine, etc. and a condensation agent, e.g., p-toluenesulfonyl chloride, etc. preferably at not higher than 40°C for 1W44hr. Prepared intermediate is separated and the alkylindene group is removed to give a compound shown by the formula.
COPYRIGHT: (C)1981,JPO&Japio
JP15292279A 1979-11-28 1979-11-28 Movel 5-fluorouridine derivative and its preparation Granted JPS5677298A (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
JP15292279A JPS5677298A (en) 1979-11-28 1979-11-28 Movel 5-fluorouridine derivative and its preparation
US06/210,796 US4340728A (en) 1979-11-28 1980-11-26 Nucleoside derivatives and process for preparing same
IT26289/80A IT1141100B (en) 1979-11-28 1980-11-27 NUCLEOSIDIC DERIVATIVES AND PROCESS FOR THEIR PREPARATION
DE19803044740 DE3044740A1 (en) 1979-11-28 1980-11-27 NUCLEOSIDE DERIVATIVES, THEIR PRODUCTION AND PHARMACEUTICAL AGENTS
FR8025348A FR2470774A1 (en) 1979-11-28 1980-11-28 NUCLEOSIDE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USES
GB8038211A GB2066812B (en) 1979-11-28 1980-11-28 5'-acyl-uridine derivatives and processes for the preparation thereof
CH883380A CH646441A5 (en) 1979-11-28 1980-11-28 NUCLEOSIDE DERIVATIVES, THEIR PRODUCTION AND THE PHARMACEUTICAL PRODUCTS CONTAINING THEM.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP15292279A JPS5677298A (en) 1979-11-28 1979-11-28 Movel 5-fluorouridine derivative and its preparation

Publications (2)

Publication Number Publication Date
JPS5677298A true JPS5677298A (en) 1981-06-25
JPS621399B2 JPS621399B2 (en) 1987-01-13

Family

ID=15551073

Family Applications (1)

Application Number Title Priority Date Filing Date
JP15292279A Granted JPS5677298A (en) 1979-11-28 1979-11-28 Movel 5-fluorouridine derivative and its preparation

Country Status (1)

Country Link
JP (1) JPS5677298A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61134397A (en) * 1984-12-01 1986-06-21 Fuji Kagaku Kogyo Kk 5'-o-oligopeptidyl-5-fluorouridine and production thereof
WO1988003146A1 (en) * 1985-04-22 1988-05-05 Fuji Kagaku Kogyo Kabushiki Kaisha Novel 5'-o-acyl-5-fluorouridines and process for their preparation
US4892939A (en) * 1986-05-30 1990-01-09 Fuji Kagaku Kogyo Kabushiki Kaisha Oligopeptidyl-5-fluorouridine compounds and process for preparing the same

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61134397A (en) * 1984-12-01 1986-06-21 Fuji Kagaku Kogyo Kk 5'-o-oligopeptidyl-5-fluorouridine and production thereof
WO1988003146A1 (en) * 1985-04-22 1988-05-05 Fuji Kagaku Kogyo Kabushiki Kaisha Novel 5'-o-acyl-5-fluorouridines and process for their preparation
US4892939A (en) * 1986-05-30 1990-01-09 Fuji Kagaku Kogyo Kabushiki Kaisha Oligopeptidyl-5-fluorouridine compounds and process for preparing the same

Also Published As

Publication number Publication date
JPS621399B2 (en) 1987-01-13

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