JPS5677298A - Movel 5-fluorouridine derivative and its preparation - Google Patents
Movel 5-fluorouridine derivative and its preparationInfo
- Publication number
- JPS5677298A JPS5677298A JP15292279A JP15292279A JPS5677298A JP S5677298 A JPS5677298 A JP S5677298A JP 15292279 A JP15292279 A JP 15292279A JP 15292279 A JP15292279 A JP 15292279A JP S5677298 A JPS5677298 A JP S5677298A
- Authority
- JP
- Japan
- Prior art keywords
- fluorouridine
- movel
- preparation
- acyl
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:A 5-fluorouridine-5'-ester derivative shown by the formula (A is N-acyl-α-aminocarboxy).
EXAMPLE: 5'-O-(N-benzyloxycarbonylmethionyl)-5-fluorouridine.
USE: An anti-malignant tumor, antiviral agnet, immunosuppressive agent, and their intermediates.
PROCESS: N-Acyl-α-aminocarboxylic acid is reacted with 2'3'-O-alkylidene-5-fluorouridine in an anhydrous solvent, e.g., benzene, in the presence of a basic compound, e.g., trialkylamine, pyridine, etc. and a condensation agent, e.g., p-toluenesulfonyl chloride, etc. preferably at not higher than 40°C for 1W44hr. Prepared intermediate is separated and the alkylindene group is removed to give a compound shown by the formula.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP15292279A JPS5677298A (en) | 1979-11-28 | 1979-11-28 | Movel 5-fluorouridine derivative and its preparation |
US06/210,796 US4340728A (en) | 1979-11-28 | 1980-11-26 | Nucleoside derivatives and process for preparing same |
IT26289/80A IT1141100B (en) | 1979-11-28 | 1980-11-27 | NUCLEOSIDIC DERIVATIVES AND PROCESS FOR THEIR PREPARATION |
DE19803044740 DE3044740A1 (en) | 1979-11-28 | 1980-11-27 | NUCLEOSIDE DERIVATIVES, THEIR PRODUCTION AND PHARMACEUTICAL AGENTS |
FR8025348A FR2470774A1 (en) | 1979-11-28 | 1980-11-28 | NUCLEOSIDE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USES |
GB8038211A GB2066812B (en) | 1979-11-28 | 1980-11-28 | 5'-acyl-uridine derivatives and processes for the preparation thereof |
CH883380A CH646441A5 (en) | 1979-11-28 | 1980-11-28 | NUCLEOSIDE DERIVATIVES, THEIR PRODUCTION AND THE PHARMACEUTICAL PRODUCTS CONTAINING THEM. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP15292279A JPS5677298A (en) | 1979-11-28 | 1979-11-28 | Movel 5-fluorouridine derivative and its preparation |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5677298A true JPS5677298A (en) | 1981-06-25 |
JPS621399B2 JPS621399B2 (en) | 1987-01-13 |
Family
ID=15551073
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP15292279A Granted JPS5677298A (en) | 1979-11-28 | 1979-11-28 | Movel 5-fluorouridine derivative and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5677298A (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS61134397A (en) * | 1984-12-01 | 1986-06-21 | Fuji Kagaku Kogyo Kk | 5'-o-oligopeptidyl-5-fluorouridine and production thereof |
WO1988003146A1 (en) * | 1985-04-22 | 1988-05-05 | Fuji Kagaku Kogyo Kabushiki Kaisha | Novel 5'-o-acyl-5-fluorouridines and process for their preparation |
US4892939A (en) * | 1986-05-30 | 1990-01-09 | Fuji Kagaku Kogyo Kabushiki Kaisha | Oligopeptidyl-5-fluorouridine compounds and process for preparing the same |
-
1979
- 1979-11-28 JP JP15292279A patent/JPS5677298A/en active Granted
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS61134397A (en) * | 1984-12-01 | 1986-06-21 | Fuji Kagaku Kogyo Kk | 5'-o-oligopeptidyl-5-fluorouridine and production thereof |
WO1988003146A1 (en) * | 1985-04-22 | 1988-05-05 | Fuji Kagaku Kogyo Kabushiki Kaisha | Novel 5'-o-acyl-5-fluorouridines and process for their preparation |
US4892939A (en) * | 1986-05-30 | 1990-01-09 | Fuji Kagaku Kogyo Kabushiki Kaisha | Oligopeptidyl-5-fluorouridine compounds and process for preparing the same |
Also Published As
Publication number | Publication date |
---|---|
JPS621399B2 (en) | 1987-01-13 |
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