JPS57149294A - Phosphoroamidate derivative, its preparation, phosphorylation agent therefrom and its use - Google Patents

Phosphoroamidate derivative, its preparation, phosphorylation agent therefrom and its use

Info

Publication number
JPS57149294A
JPS57149294A JP56036235A JP3623581A JPS57149294A JP S57149294 A JPS57149294 A JP S57149294A JP 56036235 A JP56036235 A JP 56036235A JP 3623581 A JP3623581 A JP 3623581A JP S57149294 A JPS57149294 A JP S57149294A
Authority
JP
Japan
Prior art keywords
preparation
halogen
compound
phosphoroamidate
derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP56036235A
Other languages
Japanese (ja)
Inventor
Morio Ikehara
Eiko Otsuka
Susumu Shibahara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ajinomoto Co Inc
Original Assignee
Ajinomoto Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Co Inc filed Critical Ajinomoto Co Inc
Priority to JP56036235A priority Critical patent/JPS57149294A/en
Publication of JPS57149294A publication Critical patent/JPS57149294A/en
Pending legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Saccharide Compounds (AREA)

Abstract

NEW MATERIAL:A compound of formulaI[X is halogen; substituent of formula II (R1 is H, group protecting saccharide hydroxyls; B is thymine, guanine, adenine); Y is halogen; R is 1W4C alkyl].
EXAMPLE: p-Chlorophenyl-N-p-methoxyphenylchlorophosphoroamidate.
USE: Phosphorylation agent: compared with the conventional process, the process time and a problem that the formation of by-products caused by the elimination of the protecting group in the 5'-position makes difficult to purity the final oligomer are improved.
PREPARATION: The reaction between a compound of formula III (X', Y, Z are halogen; R is 1W4C alkyl) and p-alkylaniline in an organic solvent such as ether gives the compound of formula IV.
COPYRIGHT: (C)1982,JPO&Japio
JP56036235A 1981-03-13 1981-03-13 Phosphoroamidate derivative, its preparation, phosphorylation agent therefrom and its use Pending JPS57149294A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP56036235A JPS57149294A (en) 1981-03-13 1981-03-13 Phosphoroamidate derivative, its preparation, phosphorylation agent therefrom and its use

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP56036235A JPS57149294A (en) 1981-03-13 1981-03-13 Phosphoroamidate derivative, its preparation, phosphorylation agent therefrom and its use

Publications (1)

Publication Number Publication Date
JPS57149294A true JPS57149294A (en) 1982-09-14

Family

ID=12464105

Family Applications (1)

Application Number Title Priority Date Filing Date
JP56036235A Pending JPS57149294A (en) 1981-03-13 1981-03-13 Phosphoroamidate derivative, its preparation, phosphorylation agent therefrom and its use

Country Status (1)

Country Link
JP (1) JPS57149294A (en)

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