JPS57128699A - 5-fluorouracil derivative and its medical composition - Google Patents

5-fluorouracil derivative and its medical composition

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Publication number
JPS57128699A
JPS57128699A JP1465981A JP1465981A JPS57128699A JP S57128699 A JPS57128699 A JP S57128699A JP 1465981 A JP1465981 A JP 1465981A JP 1465981 A JP1465981 A JP 1465981A JP S57128699 A JPS57128699 A JP S57128699A
Authority
JP
Japan
Prior art keywords
acyl
group
formulai
fluorouridine
purification
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP1465981A
Other languages
Japanese (ja)
Inventor
Fumio Maeda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
TOUKIYOU KINZOKU KOGYO KK
Tokyo Kinzoku Industry Co Ltd
Original Assignee
TOUKIYOU KINZOKU KOGYO KK
Tokyo Kinzoku Industry Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by TOUKIYOU KINZOKU KOGYO KK, Tokyo Kinzoku Industry Co Ltd filed Critical TOUKIYOU KINZOKU KOGYO KK
Priority to JP1465981A priority Critical patent/JPS57128699A/en
Publication of JPS57128699A publication Critical patent/JPS57128699A/en
Pending legal-status Critical Current

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  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A compound of formulaI[R1 is H, acryl; X is hydroxyl; H, O- acyl; Y is H, acyl; Z is H, acyl phosphoric group, monophosphate group, diphosphate group, residue of phosphoamidate of formula II (R3, R4 are H, alkyl, aryl)].
EXAMPLE: Diethyl 5-fluorouridine-5'-phosphate.
USE: Carcinostatic agent.
PREPARATION: For example, 2',3'-isopropylidene-5-fluorouridine is dissolved in a solvent and diarylphosphoric chloride is added thereto to effect the reaction. Then, the reaction product is isolated by a usual method and subjected to column chromatography to effect the purification. Then, the product is hydrolyzed with an aqueous acetic acid, the solvent is distilled off and the purification is conducted with column chromatography to give the compound of formulaI.
COPYRIGHT: (C)1982,JPO&Japio
JP1465981A 1981-02-03 1981-02-03 5-fluorouracil derivative and its medical composition Pending JPS57128699A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP1465981A JPS57128699A (en) 1981-02-03 1981-02-03 5-fluorouracil derivative and its medical composition

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP1465981A JPS57128699A (en) 1981-02-03 1981-02-03 5-fluorouracil derivative and its medical composition

Publications (1)

Publication Number Publication Date
JPS57128699A true JPS57128699A (en) 1982-08-10

Family

ID=11867333

Family Applications (1)

Application Number Title Priority Date Filing Date
JP1465981A Pending JPS57128699A (en) 1981-02-03 1981-02-03 5-fluorouracil derivative and its medical composition

Country Status (1)

Country Link
JP (1) JPS57128699A (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5993096A (en) * 1982-11-19 1984-05-29 Teijin Ltd 5-fluoro-2'-deoxyuridine derivative and its preparation
FR2571374A1 (en) * 1984-10-09 1986-04-11 Toyama Chemical Co Ltd NOVEL 5-FLUORO-2'-DESOXYURIDINE DERIVATIVES AND THEIR SALTS, PREPARATION METHOD THEREOF, AND ANTI-TUMOR AGENTS CONTAINING SAME
US5032680A (en) * 1988-02-29 1991-07-16 Kuraray Co., Ltd. 2'-deoxy-5-fluorouridine derivatives
US5233031A (en) * 1991-09-23 1993-08-03 University Of Rochester Phosphoramidate analogs of 2'-deoxyuridine
EP2712868A1 (en) * 2012-09-28 2014-04-02 B. Braun Melsungen AG 5-Fluoruoracil Derivatives
WO2018199048A1 (en) * 2017-04-25 2018-11-01 大原薬品工業株式会社 5'-position dibenzyl monophosphate derivative of nucleoside-based anticancer agent or antivirus agent

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5993096A (en) * 1982-11-19 1984-05-29 Teijin Ltd 5-fluoro-2'-deoxyuridine derivative and its preparation
JPS635038B2 (en) * 1982-11-19 1988-02-01 Teijin Ltd
FR2571374A1 (en) * 1984-10-09 1986-04-11 Toyama Chemical Co Ltd NOVEL 5-FLUORO-2'-DESOXYURIDINE DERIVATIVES AND THEIR SALTS, PREPARATION METHOD THEREOF, AND ANTI-TUMOR AGENTS CONTAINING SAME
US4740503A (en) * 1984-10-09 1988-04-26 Toyama Chemical Co., Ltd. Novel 5-fluoro-2'-deoxyuridine derivatives and salts thereof, process for producing the same, and antitumor agents containing the same
US5032680A (en) * 1988-02-29 1991-07-16 Kuraray Co., Ltd. 2'-deoxy-5-fluorouridine derivatives
US5233031A (en) * 1991-09-23 1993-08-03 University Of Rochester Phosphoramidate analogs of 2'-deoxyuridine
EP2712868A1 (en) * 2012-09-28 2014-04-02 B. Braun Melsungen AG 5-Fluoruoracil Derivatives
WO2014048998A1 (en) * 2012-09-28 2014-04-03 B. Braun Melsungen Ag 5-fluoruoracil derivatives
WO2018199048A1 (en) * 2017-04-25 2018-11-01 大原薬品工業株式会社 5'-position dibenzyl monophosphate derivative of nucleoside-based anticancer agent or antivirus agent
CN110678473A (en) * 2017-04-25 2020-01-10 大原药品工业株式会社 5' -dibenzyl monophosphate derivatives of nucleoside anticancer or antiviral drugs

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