JPS5455596A - Cordycepin derivative and its preparation - Google Patents

Cordycepin derivative and its preparation

Info

Publication number
JPS5455596A
JPS5455596A JP11899677A JP11899677A JPS5455596A JP S5455596 A JPS5455596 A JP S5455596A JP 11899677 A JP11899677 A JP 11899677A JP 11899677 A JP11899677 A JP 11899677A JP S5455596 A JPS5455596 A JP S5455596A
Authority
JP
Japan
Prior art keywords
formula
cordycepin
compound
preparation
pyridine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP11899677A
Other languages
Japanese (ja)
Other versions
JPS5728717B2 (en
Inventor
Susumu Shibuya
Kenjiro Kodama
Hitoshi Kusakabe
Kazuo Fujiyama
Akira Kuninaka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yamasa Shoyu KK
Original Assignee
Yamasa Shoyu KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamasa Shoyu KK filed Critical Yamasa Shoyu KK
Priority to JP11899677A priority Critical patent/JPS5455596A/en
Publication of JPS5455596A publication Critical patent/JPS5455596A/en
Publication of JPS5728717B2 publication Critical patent/JPS5728717B2/ja
Granted legal-status Critical Current

Links

Abstract

NEW MATERIAL:Cordycepin derivatives of formula I (R is alkyl). EXAMPLE:2', 5'-O-diacetylcordycepin. USE:An agent for competing with nucleic acid metabolism: it has activity inhibiting RNA synthesis and shows remarkable carcinostatic action on ascitic sarcoma 180 and cancer (ICR mouse). Further it is not deactivated by adenosine deaminease in living bodies. PREPARATION:An acid anhydride of formula III acts on cordycepin of formula II in a solvent such as pyridine to give a compound of formula I. Or an acid halide of formula IV(X is halogen) acts on cordycepin of formula X in a solvent such as pyridine to form a compound of formula V (R' is H, group of formula IV remaining after X is removed), which is hydrolyzed to give a compound of formula I.
JP11899677A 1977-10-05 1977-10-05 Cordycepin derivative and its preparation Granted JPS5455596A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP11899677A JPS5455596A (en) 1977-10-05 1977-10-05 Cordycepin derivative and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP11899677A JPS5455596A (en) 1977-10-05 1977-10-05 Cordycepin derivative and its preparation

Publications (2)

Publication Number Publication Date
JPS5455596A true JPS5455596A (en) 1979-05-02
JPS5728717B2 JPS5728717B2 (en) 1982-06-18

Family

ID=14750411

Family Applications (1)

Application Number Title Priority Date Filing Date
JP11899677A Granted JPS5455596A (en) 1977-10-05 1977-10-05 Cordycepin derivative and its preparation

Country Status (1)

Country Link
JP (1) JPS5455596A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20010054264A (en) * 1999-12-04 2001-07-02 안용준 Cordycepin separated from Cordyceps spp. for an anti-cancer medicine and its production
CN103588840A (en) * 2013-11-20 2014-02-19 武汉佰福泰制药有限公司 Method for synthetizing cordycepin

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106265713B (en) * 2012-08-23 2019-10-22 北京冠瑞金生物科技有限公司 Purposes of the cordycepin in the drug for preparing depression and its quick anti-depression drug being prepared

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20010054264A (en) * 1999-12-04 2001-07-02 안용준 Cordycepin separated from Cordyceps spp. for an anti-cancer medicine and its production
CN103588840A (en) * 2013-11-20 2014-02-19 武汉佰福泰制药有限公司 Method for synthetizing cordycepin

Also Published As

Publication number Publication date
JPS5728717B2 (en) 1982-06-18

Similar Documents

Publication Publication Date Title
DE2962643D1 (en) 3,5-dihydroxypentanoic ester derivatives having antihyperlipaemic activity, their manufacture and pharmaceutical compositions containing them
JPS5791997A (en) 5'-o-acylnucleoside and its preparation
JPS5455596A (en) Cordycepin derivative and its preparation
JPS57128699A (en) 5-fluorouracil derivative and its medical composition
JPS57193496A (en) N-acetylneuraminic acid derivative
GB1301362A (en)
JPS51118771A (en) Method for preparing carbostyryl derivatives
JPS55149299A (en) N6-substituted cordicepin derivative and its preparation
JPS5592348A (en) Preparation of 1,17-diamino-9-azaheptadecane
JPS5686198A (en) O- or m-aminobenzoic acid derivative and physiological activator containing the same
JPS5540645A (en) Benzopyrone derivative
JPS55102567A (en) Nicotinoylpantethine derivative
GB1254381A (en) Anilinoalkyl thiocarboxamides, their preparation and herbicidal compositions containing them
JPS5576900A (en) 24-fluoro-25-hydroxycholestene or its hydroxyl-protected derivative and their preparation
JPS5764651A (en) Derivative of 2-hydroxyoxanilic acid
JPS53108986A (en) Preparation of nucleosides and nucleotides
JPS5629599A (en) Novel 2-fluoro-o2'-monoacyl-adenosine-3',5'-cyclic phosphate, its preparation and carcinostatic agnet containing the same
JPS5576899A (en) 24,24-difluoro-25-hydroxycholestene derivative or its hydroxy-protected derivative and its preparation
JPS5444679A (en) Production of 5-acyluridine derivative
JPS5271489A (en) Synthesis of josamycin derivative
GB1292728A (en) Novel glucuronic acid derivatives and process for the preparation thereof
JPS5239699A (en) Improved methods of producing adenosine derivatives
ES8102146A1 (en) Procedure for the preparation of polyenmacrolide antibiotic derivatives. (Machine-translation by Google Translate, not legally binding)
JPS553733A (en) Phenazine derivative inhibiting phosphodiesterase and its preparation by microorganism
JPS57134448A (en) Production of diaralkylamine

Legal Events

Date Code Title Description
A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20060425

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20060725

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20060911

A524 Written submission of copy of amendment under section 19 (pct)

Free format text: JAPANESE INTERMEDIATE CODE: A524

Effective date: 20061025

A02 Decision of refusal

Effective date: 20070619

Free format text: JAPANESE INTERMEDIATE CODE: A02

A761 Written withdrawal of application

Free format text: JAPANESE INTERMEDIATE CODE: A761

Effective date: 20071023

A72 Notification of change in name of applicant

Effective date: 20070918

Free format text: JAPANESE INTERMEDIATE CODE: A721