ES8102146A1 - Procedure for the preparation of polyenmacrolide antibiotic derivatives. (Machine-translation by Google Translate, not legally binding) - Google Patents

Procedure for the preparation of polyenmacrolide antibiotic derivatives. (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES8102146A1
ES8102146A1 ES485140A ES485140A ES8102146A1 ES 8102146 A1 ES8102146 A1 ES 8102146A1 ES 485140 A ES485140 A ES 485140A ES 485140 A ES485140 A ES 485140A ES 8102146 A1 ES8102146 A1 ES 8102146A1
Authority
ES
Spain
Prior art keywords
polyenmacrolide
antibiotic
formula
translation
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES485140A
Other languages
Spanish (es)
Other versions
ES485140A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme Corp
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from ZA00795508A external-priority patent/ZA795508B/en
Application filed by Schering Corp filed Critical Schering Corp
Publication of ES8102146A1 publication Critical patent/ES8102146A1/en
Publication of ES485140A0 publication Critical patent/ES485140A0/en
Granted legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

Procedure for the obtaining of antibiotic derivatives of polyenmacrolide and the salts of acid addition of them. Such antibiotic derivatives have the following formula (I), where m is a portion of polyenmacrolide antibiotic containing sugar, which amino group is substituted by x; x can mean different radicals; z is 0 or 1, and and can be hirogen, alkyl, alyl, propargyl, bencilo or phenylpropargil. In its obtainment, it is part of an antibiotic of polyenmacrolide, of formula (II), where m, and and z have the meanings described above, to which it is reacted with a reagent that contains group x of formula (I). This reaction is followed by the elimination of the protective groups and/or the esterification of the compounds containing a carboxyl group. The product so obtained can be transformed into an acid addition salt. These compounds present fungicide activity. *formula* (Machine-translation by Google Translate, not legally binding)
ES485140A 1978-10-23 1979-10-18 PROCEDURE FOR THE PREPARATION OF ANTIBIOTI-CO DERIVATIVES OF POLYENMACROLIDE Granted ES485140A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US95382478A 1978-10-23 1978-10-23
ZA00795508A ZA795508B (en) 1978-10-23 1979-10-16 Derivatives of polyene macrolide antibiotics containing an amino sugar moiety, process for the preparation thereof, and pharmaceutical compositions containing them

Publications (2)

Publication Number Publication Date
ES8102146A1 true ES8102146A1 (en) 1980-12-16
ES485140A0 ES485140A0 (en) 1980-12-16

Family

ID=27130340

Family Applications (2)

Application Number Title Priority Date Filing Date
ES485140A Granted ES485140A0 (en) 1978-10-23 1979-10-18 PROCEDURE FOR THE PREPARATION OF ANTIBIOTI-CO DERIVATIVES OF POLYENMACROLIDE
ES492082A Granted ES492082A0 (en) 1978-10-23 1980-06-02 PROCEDURE FOR THE PREPARATION OF ANTIBIOTI-CO DERIVATIVES OF POLYENMACROLIDE

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES492082A Granted ES492082A0 (en) 1978-10-23 1980-06-02 PROCEDURE FOR THE PREPARATION OF ANTIBIOTI-CO DERIVATIVES OF POLYENMACROLIDE

Country Status (1)

Country Link
ES (2) ES485140A0 (en)

Also Published As

Publication number Publication date
ES8200373A1 (en) 1981-10-16
ES485140A0 (en) 1980-12-16
ES492082A0 (en) 1981-10-16

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